ID A0A6I8NX76_ORNAN Unreviewed; 628 AA.
AC A0A6I8NX76;
DT 12-AUG-2020, integrated into UniProtKB/TrEMBL.
DT 12-AUG-2020, sequence version 1.
DT 28-JAN-2026, entry version 24.
DE SubName: Full=U-box domain containing 5 {ECO:0000313|Ensembl:ENSOANP00000045501.1};
GN Name=UBOX5 {ECO:0000313|Ensembl:ENSOANP00000045501.1};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000045501.1, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000045501.1, ECO:0000313|Proteomes:UP000002279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000045501.1,
RC ECO:0000313|Proteomes:UP000002279};
RX PubMed=18464734; DOI=10.1038/nature06936;
RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT "Genome analysis of the platypus reveals unique signatures of evolution.";
RL Nature 453:175-183(2008).
RN [2] {ECO:0000313|Ensembl:ENSOANP00000045501.1}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000045501.1};
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [3] {ECO:0000313|Ensembl:ENSOANP00000045501.1}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000045501.1};
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
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DR AlphaFoldDB; A0A6I8NX76; -.
DR FunCoup; A0A6I8NX76; 1723.
DR Ensembl; ENSOANT00000047525.1; ENSOANP00000045501.1; ENSOANG00000013034.3.
DR GeneTree; ENSGT00510000049555; -.
DR InParanoid; A0A6I8NX76; -.
DR Proteomes; UP000002279; Chromosome 4.
DR Bgee; ENSOANG00000013034; Expressed in cerebellum and 7 other cell types or tissues.
DR GO; GO:0005925; C:focal adhesion; IEA:Ensembl.
DR GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IBA:GO_Central.
DR GO; GO:0034450; F:ubiquitin-ubiquitin ligase activity; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000209; P:protein polyubiquitination; IBA:GO_Central.
DR CDD; cd16660; RING-Ubox_RNF37; 1.
DR FunFam; 3.30.40.10:FF:000163; Putative ring finger protein 37; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR039925; RNF37_RING-Ubox.
DR InterPro; IPR039847; Ubox5.
DR InterPro; IPR045696; Ubox5_N.
DR InterPro; IPR003613; Ubox_domain.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR13492; RING FINGER PROTEIN 37; 1.
DR PANTHER; PTHR13492:SF2; RING FINGER PROTEIN 37; 1.
DR Pfam; PF19318; DUF5918; 1.
DR Pfam; PF04564; U-box; 1.
DR SMART; SM00504; Ubox; 1.
DR SUPFAM; SSF57850; RING/U-box; 2.
DR PROSITE; PS51698; U_BOX; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 246..326
FT /note="U-box"
FT /evidence="ECO:0000259|PROSITE:PS51698"
FT DOMAIN 461..506
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 208..244
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 363..401
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 432..451
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 230..241
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 628 AA; 66464 MW; CAFBA1B0D6D2754F CRC64;
MVINLCLPQF RPRIHCNKIS ADGYEVENLI SEDLTKRNRG FRTEYFIKPP VHITISFPFG
VEVCRVNVDL AAGGLHAATG LDVYTSTSSS RSSWGRVESQ PLGGPEKEGF TLVGKALLKS
QSRVTFSHRG FKARPPFQLP EAEPSYPGAV SQELWNRGPS SLHQVTHVKL CITHVVGGGC
PCIKRVEVWG QPARSCPHEV LASILPVASQ SPPRGPAPME SDCGPPSGSE EDRSPGLREL
ADGVPDVPEE FLDPITLEIM PFPMLLPSGK VIDRSTLEKC NRSEATWGRV PSDPFTGVAF
GHQSQPLPHP ALKARIDHFL LQHRVPGCHL LGRGQAAGLV APSSSIALPS LKRKLGCLEA
SPLGDPPAIP SSSVPPARAK KLKTDSEPSL THMDCSTGPV SHEQRLSESL DTALMSALSS
MPSFTTRLAK GLPPCSSEGS SSSWGANPAP ELTQSSAGHG CAACGRTFSP YFKTEPVYQL
PCGHLVCRPC LAVQQGSQSV LCASCKSACP VALGAKGAAS GPTSAAARSW AATWAQPRPC
AARRRTTCPR RARPDTGPVA VTGAPVPPQA SAAVMVKPQE SAPPLWPGPK SHPLSSHALP
CPSRNGNPLA LIVITELGKH LICAKGCS
//
