ID A0A6I8PE34_ORNAN Unreviewed; 844 AA.
AC A0A6I8PE34;
DT 12-AUG-2020, integrated into UniProtKB/TrEMBL.
DT 12-AUG-2020, sequence version 1.
DT 18-JUN-2025, entry version 21.
DE SubName: Full=Rho GTPase activating protein 4 {ECO:0000313|Ensembl:ENSOANP00000052939.1};
GN Name=ARHGAP4 {ECO:0000313|Ensembl:ENSOANP00000052939.1};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000052939.1, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000052939.1, ECO:0000313|Proteomes:UP000002279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000052939.1,
RC ECO:0000313|Proteomes:UP000002279};
RX PubMed=18464734; DOI=10.1038/nature06936;
RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT "Genome analysis of the platypus reveals unique signatures of evolution.";
RL Nature 453:175-183(2008).
RN [2] {ECO:0000313|Ensembl:ENSOANP00000052939.1}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000052939.1};
RG Ensembl;
RL Submitted (MAR-2025) to UniProtKB.
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DR AlphaFoldDB; A0A6I8PE34; -.
DR Ensembl; ENSOANT00000070304.1; ENSOANP00000052939.1; ENSOANG00000005180.3.
DR GeneTree; ENSGT00950000182824; -.
DR Proteomes; UP000002279; Chromosome 6.
DR Bgee; ENSOANG00000005180; Expressed in ovary and 8 other cell types or tissues.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd07656; F-BAR_srGAP; 1.
DR CDD; cd04383; RhoGAP_srGAP; 1.
DR FunFam; 2.30.30.40:FF:000136; Rho GTPase activating protein 4; 1.
DR FunFam; 1.10.555.10:FF:000010; SLIT-ROBO Rho GTPase-activating protein 1 isoform 2; 1.
DR FunFam; 1.20.1270.60:FF:000006; SLIT-ROBO Rho GTPase-activating protein 1 isoform 2; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR051627; SLIT-ROBO_RhoGAP.
DR PANTHER; PTHR14166; SLIT-ROBO RHO GTPASE ACTIVATING PROTEIN; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00055; FCH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|PROSITE-
KW ProRule:PRU01077}; GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..277
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 462..650
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 685..744
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 140..181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 366..396
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 430..454
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 763..787
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 141..156
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 366..375
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 769..780
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 844 AA; 94365 MW; 023E4148FA0717D7 CRC64;
ELRRELLQDL SEFLRRRAEV ELEYSRGLER LAERFSSRVR GNKELQSFRK DQNLLSSVHC
WYMLLNQTRQ ESRDHGVLSE MYGTSLTPRL LHISEDVGRL VKKSKDLEQH LQEELLKVVS
ELQTAMKTYQ AYRAESVNAE NKLREAERQE EKRGGKSGEL GPASGQGTDA KTPRRTSSKK
VGRLVEKRQA KYLEHKLKCT KARNEYLLSL ASVNAAVNNY YVHDVSDLLD CCDVGFHLAL
GKVLKSYVAA ETRAQTSRMQ GLAVLEGAVE GLDPLGDKAK VLEFNATAFC PPLRFDYQPY
DGDEVGEVRV ELELRDEVLP RAQNMQTRLD SQNIETEEVN KTLKATLQAL LDLVATEDGD
VLDAFQSSQS TESLKSTGSD SGSRHGSGGR RRAQQQETES FYLTKLQQYL SGRSILTKLQ
AKHERLQEAI QRGDVAHSGA GKSQRSRRQR PSSQYNHKLF AGDMEKFIQS SGQAVPLVVE
SCIRFINLHG LQHEGIFRVP GAQVRVTEIR SAFERGEDPL LDGYTAHDLD SVAGVLKLYF
RGLETPLFPP EMFEQLLATV QLEAPSERVE YVKTMMSQLP SPILVVLRYL FAFLNHLSQY
SDENMMDPYN LAVCFGPTLV SVPPDQDPVA VQAHVNEVVK TLILQQEHVF PGPRQLPGPI
YEKCMTLAEE DFGDSQLEPT AEEADEVVEA TARFDYVGRT AQELSFQRGD VLQLHLKASG
DWWRGERAGV HGLIPHKYIT LLEGASIPLL MLSQRGDPAA FLDAAASPFP TPPSPPPSPR
PSQDSFRSPL DPIFGTYPIF PSPRLLSLPN PSQLFYGGLD WVWSRNPGPA PPGPTLPSSV
GLIS
//
