ID A0A6I8T7I6_AEDAE Unreviewed; 1233 AA.
AC A0A6I8T7I6;
DT 12-AUG-2020, integrated into UniProtKB/TrEMBL.
DT 12-AUG-2020, sequence version 1.
DT 18-JUN-2025, entry version 22.
DE RecName: Full=Transient receptor ion channel domain-containing protein {ECO:0000259|SMART:SM01420};
GN Name=5565862 {ECO:0000313|EnsemblMetazoa:AAEL005014-PI};
OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7159 {ECO:0000313|EnsemblMetazoa:AAEL005014-PI, ECO:0000313|Proteomes:UP000008820};
RN [1] {ECO:0000313|EnsemblMetazoa:AAEL005014-PI, ECO:0000313|Proteomes:UP000008820}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LVP_AGWG {ECO:0000313|EnsemblMetazoa:AAEL005014-PI,
RC ECO:0000313|Proteomes:UP000008820};
RG Aedes aegypti Genome Working Group (AGWG);
RA Matthews B.J.;
RT "Aedes aegypti genome working group (AGWG) sequencing and assembly.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AAEL005014-PI}
RP IDENTIFICATION.
RC STRAIN=LVP_AGWG {ECO:0000313|EnsemblMetazoa:AAEL005014-PI};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, rhabdomere membrane
CC {ECO:0000256|ARBA:ARBA00043946}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00043946}.
CC -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family. STrpC
CC subfamily. {ECO:0000256|ARBA:ARBA00060916}.
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DR AlphaFoldDB; A0A6I8T7I6; -.
DR SMR; A0A6I8T7I6; -.
DR EnsemblMetazoa; AAEL005014-RI; AAEL005014-PI; AAEL005014.
DR OrthoDB; 2373987at2759; -.
DR Proteomes; UP000008820; Chromosome 2.
DR GO; GO:0034703; C:cation channel complex; IEA:TreeGrafter.
DR GO; GO:0005886; C:plasma membrane; IEA:TreeGrafter.
DR GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:TreeGrafter.
DR GO; GO:0015279; F:store-operated calcium channel activity; IEA:TreeGrafter.
DR GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; IEA:TreeGrafter.
DR FunFam; 1.25.40.20:FF:000221; Transient receptor potential-gamma protein; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR013555; TRP_dom.
DR InterPro; IPR002153; TRPC_channel.
DR PANTHER; PTHR10117; TRANSIENT RECEPTOR POTENTIAL CHANNEL; 1.
DR PANTHER; PTHR10117:SF54; TRANSIENT RECEPTOR POTENTIAL-GAMMA PROTEIN; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF08344; TRP_2; 1.
DR PRINTS; PR01097; TRNSRECEPTRP.
DR SMART; SM00248; ANK; 2.
DR SMART; SM01420; TRP_2; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043};
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008820};
KW Sensory transduction {ECO:0000256|ARBA:ARBA00023305};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Vision {ECO:0000256|ARBA:ARBA00023305}.
FT TRANSMEM 577..599
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 667..692
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 255..317
FT /note="Transient receptor ion channel"
FT /evidence="ECO:0000259|SMART:SM01420"
FT REGION 1..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 965..1046
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1061..1095
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1136..1233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..54
FT /note="Gly residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1031..1046
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1068..1080
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1142..1151
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1233 AA; 137845 MW; 6D10EBCC3FE64F9B CRC64;
MESTILKSKL FVKNEKSAAR RTSTPEGMTL RARGGDDASE STGGGGGGGT GGGGGDKKDT
KIDIPLPQYM HPAAEKFADK RVKRHSIHGM MEEENVVRPH QEIAALSLDE KKYLLAVERG
DVASTRRILE KAEAEGHINI NCVDPLGRSA LLMAIDNENL EMVELLINHK MDTKDALLHA
ISEEFVEAVE VLLDHEDSCH KNGDPHSWEA LPPDTATFTP DITPLILAAH RDNYEIIKIL
LDRGATLPMP HDVRCGCDDC VTSRQEDSLR HSRSRINAYR ALASPSLVAL SSKDPILTAF
ELSWELRRLS FLEHEFKNEY QELRRQCQDF ATALLDHTRS SHELEVLLNH DPTGPAFEHG
DRMHLNRLKL AVKLRQKKFV SHPNVQQLLA SIWYEGLPGF RRKNMALQAL EIVRIVLLML
ASQRIETVIG GVWGAEMSSH DEVPTKRGAS PTLVEWLILA WVSGLIWSEV KQLWDVGLQE
YVNDMWNVID FVTNSLYVAT VALRVVSYFE VQKEMAINRF AADLPREKWD TWDPMLISEG
LFSAANIFSS LKLVYIFSVN PHLGPLQVSL SRMVMDIMKF FFLYVLVLFA FSSGLNQLLW
YYADLEKKRC PDASAFSNMT STDPNACVVW RRFANLFETI QTLFWAVFGL VDLENFELDG
IKIFTRFWGM LMFGTYSVIN IVVLLNLLIA MMNHSYQLIS ERADVEWKFA RSKLWISYFE
EGGTCPPPFN IIPTPKSIFY VFQWVKRKFC GHSKAVKKEH MKTIRRKVKQ ASERDFRYQS
IMRNLVRRYV TVEQRKAESQ GVTEDDVNEI KQDISAFRCE LVEILKNSGM NTTSATGSGS
GVGGKKNRQK ERRLMKGFNI APPPAPEGGQ HLTPVSEFIS QLPEHSSHEL FAGVFGPGLT
PKKALHQVNP MHQFSSQSQS SFGENNNAMH KLSKLAPKFH SKRPNSQKKR WGTLIEAAKH
GSVSKFIGRS RSEDSVCNHG PRGESASHSN SPASDEAITE SPSDSNPSLD RPEVEASPDP
TKHHQHQHQH GGSDKSHGGK TKDSSHHHYH LHFGALAALK RKRKKFSNSR NSSPVLEPPN
EAVPPVAPVN NSSSKVLKRA SSVPSSRSGC EEGVVGNAGG VIVEGATEDI GVPLKTPRHE
QTQSQHNSME NQLEPPLTPS TTEESVDNPS HVRISSTEPL LRIQGRAVTI DELTNPGGRS
GGPSGASQRH QQPSYRIPGV TPVRGHFQSQ GWL
//
