ID A0A6I8TAJ5_AEDAE Unreviewed; 1273 AA.
AC A0A6I8TAJ5;
DT 12-AUG-2020, integrated into UniProtKB/TrEMBL.
DT 12-AUG-2020, sequence version 1.
DT 18-JUN-2025, entry version 23.
DE RecName: Full=Transient receptor ion channel domain-containing protein {ECO:0000259|SMART:SM01420};
GN Name=5565862 {ECO:0000313|EnsemblMetazoa:AAEL005014-PH};
OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7159 {ECO:0000313|EnsemblMetazoa:AAEL005014-PH, ECO:0000313|Proteomes:UP000008820};
RN [1] {ECO:0000313|EnsemblMetazoa:AAEL005014-PH, ECO:0000313|Proteomes:UP000008820}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LVP_AGWG {ECO:0000313|EnsemblMetazoa:AAEL005014-PH,
RC ECO:0000313|Proteomes:UP000008820};
RG Aedes aegypti Genome Working Group (AGWG);
RA Matthews B.J.;
RT "Aedes aegypti genome working group (AGWG) sequencing and assembly.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AAEL005014-PH}
RP IDENTIFICATION.
RC STRAIN=LVP_AGWG {ECO:0000313|EnsemblMetazoa:AAEL005014-PH};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, rhabdomere membrane
CC {ECO:0000256|ARBA:ARBA00043946}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00043946}.
CC -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family. STrpC
CC subfamily. {ECO:0000256|ARBA:ARBA00060916}.
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DR AlphaFoldDB; A0A6I8TAJ5; -.
DR SMR; A0A6I8TAJ5; -.
DR EnsemblMetazoa; AAEL005014-RH; AAEL005014-PH; AAEL005014.
DR OrthoDB; 2373987at2759; -.
DR Proteomes; UP000008820; Chromosome 2.
DR GO; GO:0034703; C:cation channel complex; IEA:TreeGrafter.
DR GO; GO:0005886; C:plasma membrane; IEA:TreeGrafter.
DR GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:TreeGrafter.
DR GO; GO:0015279; F:store-operated calcium channel activity; IEA:TreeGrafter.
DR GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; IEA:TreeGrafter.
DR FunFam; 1.25.40.20:FF:000221; Transient receptor potential-gamma protein; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR013555; TRP_dom.
DR InterPro; IPR002153; TRPC_channel.
DR NCBIfam; TIGR00870; trp; 1.
DR PANTHER; PTHR10117; TRANSIENT RECEPTOR POTENTIAL CHANNEL; 1.
DR PANTHER; PTHR10117:SF54; TRANSIENT RECEPTOR POTENTIAL-GAMMA PROTEIN; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF08344; TRP_2; 1.
DR PRINTS; PR01097; TRNSRECEPTRP.
DR SMART; SM00248; ANK; 2.
DR SMART; SM01420; TRP_2; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043};
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008820};
KW Sensory transduction {ECO:0000256|ARBA:ARBA00023305};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Vision {ECO:0000256|ARBA:ARBA00023305}.
FT TRANSMEM 409..429
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 441..462
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 618..640
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 708..733
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 255..317
FT /note="Transient receptor ion channel"
FT /evidence="ECO:0000259|SMART:SM01420"
FT REGION 1..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1005..1086
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1101..1135
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1176..1273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..54
FT /note="Gly residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1071..1086
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1108..1120
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1182..1191
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1273 AA; 142465 MW; 74593F567D32E729 CRC64;
MESTILKSKL FVKNEKSAAR RTSTPEGMTL RARGGDDASE STGGGGGGGT GGGGGDKKDT
KIDIPLPQYM HPAAEKFADK RVKRHSIHGM MEEENVVRPH QEIAALSLDE KKYLLAVERG
DVASTRRILE KAEAEGHINI NCVDPLGRSA LLMAIDNENL EMVELLINHK MDTKDALLHA
ISEEFVEAVE VLLDHEDSCH KNGDPHSWEA LPPDTATFTP DITPLILAAH RDNYEIIKIL
LDRGATLPMP HDVRCGCDDC VTSRQEDSLR HSRSRINAYR ALASPSLVAL SSKDPILTAF
ELSWELRRLS FLEHEFKNEY QELRRQCQDF ATALLDHTRS SHELEVLLNH DPTGPAFEHG
DRMHLNRLKL AVKLRQKKFV SHPNVQQLLA SIWYEGLPGF RRKNMALQAL EIVRIGMLFP
LFSISYIIAP HSTFGQTMRK PFIKFICHSA SYFTFLFLLM LASQRIETVI GGVWGAEMSS
HDEVPTKRGA SPTLVEWLIL AWVSGLIWSE VKQLWDVGLQ EYVNDMWNVI DFVTNSLYVA
TVALRVVSYF EVQKEMAINR FAADLPREKW DTWDPMLISE GLFSAANIFS SLKLVYIFSV
NPHLGPLQVS LSRMVMDIMK FFFLYVLVLF AFSSGLNQLL WYYADLEKKR CPDASAFSNM
TSTDPNACVV WRRFANLFET IQTLFWAVFG LVDLENFELD GIKIFTRFWG MLMFGTYSVI
NIVVLLNLLI AMMNHSYQLI SERADVEWKF ARSKLWISYF EEGGTCPPPF NIIPTPKSIF
YVFQWVKRKF CGHSKAVKKE HMKTIRKVKQ ASERDFRYQS IMRNLVRRYV TVEQRKAESQ
GVTEDDVNEI KQDISAFRCE LVEILKNSGM NTTSATGSGS GVGGKKNRQK ERRLMKGFNI
APPPAPEGGQ HLTPVSEFIS QLPEHSSHEL FAGVFGPGLT PKKALHQVNP MHQFSSQSQS
SFGENNNAMH KLSKLAPKFH SKRPNSQKKR WGTLIEAAKH GSVSKFIGRS RSEDSVCNHG
PRGESASHSN SPASDEAITE SPSDSNPSLD RPEVEASPDP TKHHQHQHQH GGSDKSHGGK
TKDSSHHHYH LHFGALAALK RKRKKFSNSR NSSPVLEPPN EAVPPVAPVN NSSSKVLKRA
SSVPSSRSGC EEGVVGNAGG VIVEGATEDI GVPLKTPRHE QTQSQHNSME NQLEPPLTPS
TTEESVDNPS HVRISSTEPL LRIQGRAVTI DELTNPGGRS GGPSGASQRH QQPSYRIPGV
TPVRGHFQSQ GWL
//
