ID A0A6I8TF22_AEDAE Unreviewed; 4685 AA.
AC A0A6I8TF22;
DT 12-AUG-2020, integrated into UniProtKB/TrEMBL.
DT 12-AUG-2020, sequence version 1.
DT 18-JUN-2025, entry version 19.
DE RecName: Full=Dynein heavy chain, cytoplasmic {ECO:0000256|ARBA:ARBA00022197};
DE AltName: Full=Dynein heavy chain, cytosolic {ECO:0000256|ARBA:ARBA00033439};
GN Name=5568788 {ECO:0000313|EnsemblMetazoa:AAEL007132-PH};
OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7159 {ECO:0000313|EnsemblMetazoa:AAEL007132-PH, ECO:0000313|Proteomes:UP000008820};
RN [1] {ECO:0000313|EnsemblMetazoa:AAEL007132-PH, ECO:0000313|Proteomes:UP000008820}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LVP_AGWG {ECO:0000313|EnsemblMetazoa:AAEL007132-PH,
RC ECO:0000313|Proteomes:UP000008820};
RG Aedes aegypti Genome Working Group (AGWG);
RA Matthews B.J.;
RT "Aedes aegypti genome working group (AGWG) sequencing and assembly.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AAEL007132-PH}
RP IDENTIFICATION.
RC STRAIN=LVP_AGWG {ECO:0000313|EnsemblMetazoa:AAEL007132-PH};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBUNIT: Consists of at least two heavy chains and a number of
CC intermediate and light chains. {ECO:0000256|ARBA:ARBA00011655}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR EnsemblMetazoa; AAEL007132-RH; AAEL007132-PH; AAEL007132.
DR OrthoDB; 14187at2759; -.
DR Proteomes; UP000008820; Chromosome 3.
DR GO; GO:0005858; C:axonemal dynein complex; IEA:TreeGrafter.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd00009; AAA; 2.
DR FunFam; 1.20.920.20:FF:000002; Cytoplasmic dynein 1 heavy chain; 1.
DR FunFam; 3.40.50.300:FF:000122; Cytoplasmic dynein 1 heavy chain; 1.
DR FunFam; 1.10.8.1220:FF:000002; cytoplasmic dynein 1 heavy chain 1-like; 1.
DR FunFam; 1.10.287.2620:FF:000001; Cytoplasmic dynein heavy chain 1; 1.
DR FunFam; 1.10.472.130:FF:000002; Cytoplasmic dynein heavy chain 1; 1.
DR FunFam; 1.10.8.710:FF:000005; Cytoplasmic dynein heavy chain 1; 1.
DR FunFam; 1.20.140.100:FF:000002; Cytoplasmic dynein heavy chain 1; 1.
DR FunFam; 1.20.58.1120:FF:000003; Cytoplasmic dynein heavy chain 1; 1.
DR FunFam; 1.20.920.30:FF:000001; Cytoplasmic dynein heavy chain 1; 1.
DR FunFam; 3.20.180.20:FF:000002; Cytoplasmic dynein heavy chain 1; 1.
DR FunFam; 3.40.50.300:FF:000071; Cytoplasmic dynein heavy chain 1; 1.
DR FunFam; 3.40.50.300:FF:000517; Cytoplasmic dynein heavy chain 1; 1.
DR FunFam; 1.10.8.720:FF:000003; Cytoplasmic dynein heavy chain 2; 1.
DR FunFam; 1.20.1270.280:FF:000004; Cytoplasmic dynein heavy chain 2; 1.
DR FunFam; 3.10.490.20:FF:000004; Cytoplasmic dynein heavy chain 2; 1.
DR FunFam; 3.40.50.300:FF:000373; Cytoplasmic dynein heavy chain 2; 1.
DR FunFam; 3.40.50.300:FF:001956; Dynein cytoplasmic 1 heavy chain 1; 1.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC.
DR InterPro; IPR054354; DYNC2H1-like_lid.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46532:SF13; CYTOPLASMIC DYNEIN 1 HEAVY CHAIN 1; 1.
DR PANTHER; PTHR46532; MALE FERTILITY FACTOR KL5; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF22597; DYN_lid; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 4.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000008820};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1918..2070
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2242..2393
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2612..2762
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2954..3120
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
SQ SEQUENCE 4685 AA; 534600 MW; FB02D556E4CF00D2 CRC64;
MGDSLEATVG SMGSDPPQSV GVVDTESVAI MDYDGFTNYI RKAVTILLPE EDVVPVPLNA
ALDDPSNQEC IRKFLSDPQT QALYIQRSCF KDDENEPPTE GEEEKDAVTY YISNDVHFTN
QRMASLVCIK RGSVIEADKS IHSQIRLINF SEGSPYETLH SFISKTLAPY FKSYVKESGR
ADRDGDKMAP SVEKKLTELE MGLLHLQQNI DIPEVTLNIN GTVAQVVKKC ADEGRKAKIT
DFGDKVEDST FLNLLQNGVN RWIKEIQKVT KLDRDPSSGT ALQEISFWLN LERALHRIQE
KRESPEVALT LNILKHGKRF HATVSFDTDT GLKQTLAMVA DYNPLMKDFP INDLLSATEL
DKIRQAVQSI FNHLRKIRST KYPIQRCLRL IEAISRDLSQ QLLKVLGTRR LMHIPFDEFE
RVMNQCFEVF SCWDDEYDKL QGILRDIVKK KRDEHIKMVW RIAPAHKKLQ QRMEHMRKFR
RQHEQLRTVI VRVLRPARQP AGMSGGGDAG SADVKQPYSL DTADANAIEE VNLAYENVKE
IECLDISKEG SEAWDAAIKR YEERIDRVET RITAHLRDQL GTAKNANEMF RIFSRFNALF
VRPHIRGAIR EYQTQLIQRV KDDIEALHEK FKVQYPQSKS CRLSVVRDLP PVAGSIIWAR
QIDNQLTMYL KRVEDVLGKG WESHIDGQKL KADGDSFRAK LSTAEVFQEW ARKVQERNTG
ITGRIFLIES TRSRTGRGNT LRLRVNFLPE IITLYKEVRN LKSLGFRVPL AIVNKAHQAN
QLYPFAISLI ESVRTYERTL EKLTNRSLAQ NSVFKIEDRA SIIPLVAGLR KEVLALISEG
IALVWESYKL DPYVQRLSEN VTSFQEKVED LLVVEEQLDV DVRSLETCPY SAATFADILS
KIQHAVDDLS LKQYSNLHVW VARLDEEVEK KLAARLQAGI QAWTDALTGN KKEVDLSMDT
DAPAQPTIKP GGDPQIQKAI HEIRITNQQM YLYPSIEEAR FQIMQQLFAW EAIVTSQTRL
QSSRYQVGLD KPVSQTYRNL LTKLPGGSDP LEGSYAAIEN QISEVRNYVD EWLRYQSLWD
LQADTLYGRL GEDINLWIKC LNDIKKSRTT FDTSDTRRAY GPIVIDYAKV QAKVTLKYDS
WHKEALSKFG QLLGNEMSTF HGKVSKSRSD LEQQSIEAAS TSDAVCFITY VQSLKKEMLV
WDKQVEVYRE AQRILERQRF QFPSNWLHVD NIEGEWSAFN EIMKRKDSAI QTQVASLQAK
IVAEDKAVES RTLDFLNDWE KNKPTGGRTR PDDALQQLHI FETKFSRLKE ERDNVAKAKE
ALELQESAIP NNSTERMNVV LEELQDLRGV WSELSKIWAQ IDETREKPWL SVQPRKLRQS
LEAMMNQLKE LPARLRMYES YEYVKKLLQS YIKVNMMIVE LKSDALKERH WKQLTKQLRV
SWVLSDLTLG QVWDVNLLKN ESIVKDIILV AQGEMALEEF LKQVRESWQN YELDLINYQN
KCRIIRGWDD LFNKVKEHIN SVAAMKLSPY YKVFEEEALT WEEKLNRINS LFDVWIDVQR
RWVYLEGIFS GSADIKTLLP VETSRFQSIS SEFLGLMKKV AKSPKVMDVL NIPAVQRSLE
RLADLLGKIQ KALGEYLERE RTSFPRFYFV GDEDLLEIIG NSKNVARLQK HFKKMFAGVA
SILLNEDNTV ILGIASREGE EVKFIKPVST VEHPKINEWL TLVEKEMRFT LASYLAQAVQ
DIKQFKDEID PQKYMEWCDK YQAQIVVLAA QILWSEDVEA ALQQASDSPG NKSPLNRVLA
TVETTLNVLA DSVLQEQPQL RRKKLEHLIN EFVHKRTVTR RLIAHGVNNP KSFHWLCEMR
FYFDPRQTEV LQQLTIHMAN ARFYYGFEYL GVQDRLVQTP LTDRCYLTMT QALEARLGGS
PFGPAGTGKT ESVKALGNQL GRFVLVFNCD ETFDFQAMGR IFVGLCQVGA WGCFDEFNRL
EERMLSAVSQ QIQTIQEALK SLQEGSMKDS QSITVELVGK QVRVSTDMAI FITMNPGYAG
RSNLPDNLKK LFRSLAMTTP DRQLIAEVML FSQGFRTAEK LACKIVPFFK LCDEQLSNQS
HYDFGLRALK SVLVSAGNVK RDRIMKIKDT MKQRGEENID EASIAENLPE QEILIQSVCE
TMVPKLVAED IPLLFSLLSD VFPNVGYTRA EMKGLKDEIR KVCAEEYLVC GEGDEQGGAW
MEKGFGETWV DKVLQLYQIS NLNHGLMMVG PSGSGKSTAW RVLLKALERF EGVEGVAHVI
DPKAISKETL YGVLDPNTRE WTDGLFTHIL RKIIDNVRGE INKRQWIIFD GDVDPEWVEN
LNSVLDDNKL LTLPNGERLS LPPNVRIMFE VQDLKYATLA TVSRCGMVWF SEDVLSTEMI
FENYMSRLKN IPLEDGEEES FTTQSKGVDK DDELTPALQT QREIASLLQP YFTSDGLVVR
CLDYAMGQEH IMDFTRLRAL SSLFSMLNQG ARNVLNFNQQ HPDFPVPPEQ LEQYIPKLLI
YSLLWSFAGD AKLKVRSDLG DFVRSVTTVT LPAQSGNPII DFEVTLQGEW APWSNKVPVI
EVETHKVAAP DVVVPTLDTV RHESLLYTWL AEHKPLVLCG PPGSGKTMTL FSALRALPDM
EVVGLNFSSA TTPELLLKTF DHYCEYRKTP NGVVLAPVQL GKWLVLFCDE INLPDMDSYG
TQRVISFLRQ LVEHKGFYRA ADQSWVSLER IQFVGACNPP TDPGRKPLSH RFLRHVPIIY
VDYPGETSLK QIYGTFSRAM LRLMPNLRGY AEPLTNAMVE FYLASQDRFT QDMQPHYVYS
PREMTRWVRG ICEAIRPLDN LPVEGLVRLW AHEALRLFQD RLVEESERRW TNENIDLVAM
KHFPSVDREK ALERPILYSN WLSKDYMPVN RSELRDYVKA RLKVFYEEEL DVPLVLFDEV
LEHVLRIDRI FRQPQGHLLL IGVSGAGKTT LSRFVAWMNG LSIFQIKVHN KYTSEDFDED
LRCVLRRAGC KDEKIAFILD ESNVLDSGFL ERMNTLLANG EVPGLFEGDE YTTLMTQCKE
GAQREGLMLD SSDELYKWFT QQVMRNLHVV FTMNPSTDGL KDRAATSPAL FNRCVLNWFG
DWSDSALFQV GKEFTVRVDL DKPTWSAPDF FPAACPLINN TPSHRDAVIN ACVYVHQTLH
KANARLAKRG GRTMAITPRH YLDFIHHFVK LYSEKRSDLE EQQLHLNVGL NKIAETVEQV
EEMQKSLAVK SQELQAKNEA ANAKLKQMFK DQQEAEKKKV QSQEIQQQLV EQTVKIEMKR
KDVMADLDLV EPAVIDAQAA VSNIKKKQLA EVRTMANPPA PVKLALESVC LLLGEDDRGG
DWKAIRGILV KDSFITSIVK FDTSQLTDDV REKMKSRYLS NPDYNFEKVN RASMACGPMV
KWAIAQVEYA DMLKRVEPLR DELSSLERRA DTNIKHGQEV KELIAQLEQS IASYKEEYAQ
LISQAQAIKT DLENVQAKVD RSIALLKSLV IERERWEATS ETFRSQMSTI IGDVLLSAAF
IAYGGYFDQH YRSNLFSTWC QHLQAASIQF RADIARTEYL SNPDERLRWQ ANALPTDDLC
TENAIMLKRF NRYPLIIDPS GQATEFIMNE FKDKKITKTS FLDDSFRKNL ESALRFGNPL
LVQDVENYDP ILNPVLNREL RRTGGRVLIT LGDQDIDLSP SFVIFLSTRD PTVEFPPDIC
SRVTFVNFTV TRSSLQSQCL NQVLKAERPD IDEKRSDLLK LQGEFHLRLR QLEKSLLQAL
NDAKGKILDD DSVITTLETL KKEAADIGQK VEETDKVIAE IETVSQQYLS LSQACSNIYF
TMDSLNQVHF LYQYSLKMFL DIFSTVLHNN PKLEGKTDHT GRLSIITNDL YRVCYDRVAR
GMLHADRLTF AILLCRIHLK GTTEANLDQE FNFFLRNKEG LFSSSNHVDG VSAEQLESVT
RLSSRLPIFR KLLEKIQSMP ELSAWLQQGS PEQNVPNLWD ESKALSAISG AMHQLLLIQA
FRPDRVIAAA HIFVSTVLGE DFMPQAEKEL DFSTCVEKEL TSNTPALLCS VTGYDASSRV
DDLAAELNKQ ITSIAIGSAE GFNQAERVIN MACKTGRWVL LKNVHLAPQW LVQLEKKLHS
LQPHSGFRLF LTMEINPKVP VNLLRAGRIF VYEPPPGIRA NLLRTFSTVP ASRMMKQPSE
RARLYFLLSW FHAIVQERLR YAPLGWAKKY EFNESDLRVA CDTLDTWIDA TAMGRTNLPP
EKVPWDALVT LLSQSIYGGK IDNDFDQRLL SSFLSKLFTA HSFEAEFALV ANVDGVAGGP
NGQRHITMPD GTRRDHFLKW IEALADRQTP SWLGLPNNAE KVLLTTRGTD LVSKLLKMQQ
LEDDDELAYS HDESLDAVQT RQEDGRPSWM KTLHNSALTW LQLLPKQLAT LKRTVENIKD
PLYRYFEREV SCGAKLLQTV VSDLQDVVYI CQGEKKQTNY HRTMLSELVR GILPAGWRRY
TVPAGCTVIQ WITDFSHRVL QLQKVSSLVS QAGAKELQSF PVWLGGLFNP EAYITATRQC
VAQANSWSLE ELALNVTITE NGSDGIDNLK DSSFGVSGLK LQGAQCKNNQ LLLTSAIMTE
LPLTLLKWTR IDSDSARATK LTLPVYLNST RTELLFTVDM TVAPGQDPHS FYERGVAVLA
STALN
//
