ID A0A6I8TVL7_AEDAE Unreviewed; 2311 AA.
AC A0A6I8TVL7;
DT 12-AUG-2020, integrated into UniProtKB/TrEMBL.
DT 12-AUG-2020, sequence version 1.
DT 18-JUN-2025, entry version 16.
DE RecName: Full=Nucleoprotein TPR {ECO:0000256|ARBA:ARBA00019789};
GN Name=5579176 {ECO:0000313|EnsemblMetazoa:AAEL019783-PA};
OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7159 {ECO:0000313|EnsemblMetazoa:AAEL019783-PA, ECO:0000313|Proteomes:UP000008820};
RN [1] {ECO:0000313|EnsemblMetazoa:AAEL019783-PA, ECO:0000313|Proteomes:UP000008820}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LVP_AGWG {ECO:0000313|EnsemblMetazoa:AAEL019783-PA,
RC ECO:0000313|Proteomes:UP000008820};
RG Aedes aegypti Genome Working Group (AGWG);
RA Matthews B.J.;
RT "Aedes aegypti genome working group (AGWG) sequencing and assembly.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AAEL019783-PA}
RP IDENTIFICATION.
RC STRAIN=LVP_AGWG {ECO:0000313|EnsemblMetazoa:AAEL019783-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the TPR family. {ECO:0000256|ARBA:ARBA00005274}.
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DR FunCoup; A0A6I8TVL7; 2489.
DR EnsemblMetazoa; AAEL019783-RA; AAEL019783-PA; AAEL019783.
DR InParanoid; A0A6I8TVL7; -.
DR OrthoDB; 343070at2759; -.
DR Proteomes; UP000008820; Chromosome 3.
DR GO; GO:0034399; C:nuclear periphery; IEA:UniProtKB-ARBA.
DR GO; GO:0005643; C:nuclear pore; IEA:UniProtKB-ARBA.
DR GO; GO:0017056; F:structural constituent of nuclear pore; IEA:TreeGrafter.
DR GO; GO:0006406; P:mRNA export from nucleus; IEA:TreeGrafter.
DR GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR GO; GO:1901673; P:regulation of mitotic spindle assembly; IEA:TreeGrafter.
DR Gene3D; 1.20.1170.10; -; 1.
DR InterPro; IPR012929; TPR/MLP1.
DR PANTHER; PTHR18898:SF2; NUCLEOPROTEIN TPR; 1.
DR PANTHER; PTHR18898; NUCLEOPROTEIN TPR-RELATED; 1.
DR Pfam; PF25481; Nucleoprot-TPR; 1.
DR Pfam; PF07926; TPR_MLP1_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000008820}.
FT DOMAIN 1119..1245
FT /note="Nucleoprotein TPR/MLP1"
FT /evidence="ECO:0000259|Pfam:PF07926"
FT REGION 1..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1583..1626
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1740..2311
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 113..228
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 264..443
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 476..545
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 735..769
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 809..1248
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1317..1344
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1372..1427
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1453..1561
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 20..30
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 31..40
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1583..1592
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1596..1606
FT /note="Gly residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1610..1626
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1740..1764
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1799..1819
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1823..1837
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1850..1909
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1946..1961
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1976..2002
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2068..2132
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2168..2208
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2209..2263
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2275..2285
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2311 AA; 258807 MW; 94B15116C7BC46FE CRC64;
MEVDENPEVT AGVPNVATTT EEKEAEEGQE KSSPMETATP QEKEEQQEAP SSPKATAPEE
EPEKEEPSAG GGGVLRSILS EEELTAIPAE TTKKIEGHYE QKLEEFLTAK ALCETAKTNV
EQIKVDYEKQ IEELTLKYQD ESSKYHFSQQ SIKELRLELE DCKQEMAQAR DKVKQNDADT
ARFRRERNEA VNERDTLLNA VERKTLEVER LQADVMALEH KLKAANVTKC EALAKLEEIQ
SKEFSLDFKE KRMDKELSMR DNQISKLTED LNRALQDLQN VRRDQNFKAL TTETKLTEKT
EELKIATAQI AHLNEQNQEL STRAEDLASK LLQQSEETRK MMDHYRKELQ SQTKLCELYQ
EDCEDNKKQT EELGAAVSEL KKLLNEASDS YGKLETQQKT LVMKHEKELE AKNQVIQQLK
DELKNANELL KLARQENLEH AVEKLAPTAA ATSRLIKSGM TLTELYTMYV KTAEDLQVEK
KENSKLQLQI KNIVQELEER APELTRQQNE YQNLKDANEE MSLQLNKLIE ENADVRSELT
SMQDKVRYLD SENKKFKLER GDLSRQICHL LREIEQMRGG YASEADQSIS SDMSANEVIT
KKLVTFSDIQ ELQENNVKLL LVVRDFSAKL EELEVAQNAM SQATFEAKIA SYNKRLQEMQ
ETQEYQTQMM QQCIQQRDRY KKMYHDAMRS YNAVGGKGTL GASLNGSLSG ENADAAMDEE
IPSGSTVSAI SSEAVVEKEK KIAELEAKVK ENQQMLSTLK EEYDNYRKEK LTNDKMMNEQ
FDSMRTELRE LSSKNIKLVA TVEYNNEQIK IQQKNVATYK KQIATLEERN KNYETTISKQ
EATIMYLKDE TMSAQSKLAR AEVQVENLKH ECRILKDAES RLQTEREILN RERQNQNLLL
NNLEMIKVTM ERSEAEGRIR LETRLDETAR ECSALRRRLQ EEQDRFRELT THLERQMQTT
KQRMEEEMAI AETVQAELKN ARDELEIKSR KIDDLSKKLQ ETLSPNDEDN PVTQAFKKIR
ELEQKLSENE IEFESLRKEL ATAKEHVKQY CNMSESSEKE LKDLNELYTT YKTQTETELG
TLKKNEAELK AQVEELKTEI SLKKTGEQLT SSTDSESALH KVQVELKEAL EKITENNKDL
RELREKNNSL LEQLQVAEQK YANEMVQHSS DIQQLSILKE DVQKTKQQFD ELKLARDQAI
ERFNTSEECW KNREEMMKKE IEQLEERLSD LNSQNAALHD QIQSLSTKLS ITAAQALEQK
AADESMNESA MDDSSVLNKS ISDEEKRSVD QLLQIIKYLR KEKDIAVAKF DILRSENVRV
QSELMMFQKK LEEAQAQLAQ EREKSETGVV TAAKHEDILR KLETFNAITD SNRVLREERD
GLNKRIRELS ERLLKAEDEL FPLQEKVREL SVKIESATSE NSTLRLEATR WRQRANLLVE
RSNKTSPEDW KRLQTERENL AKMLTQEKEL LKKSNEELNS IRVEKGKLET EVTNLTKQLT
GATEQNKKYA EELDVLRQAG AKMTTEIGEV KTTLTKRDED LLKLTDELSN KDKELTDAKS
KEQQIRKIAK RYKDSYIELK KQVDEKDGEG AKTAEGGAGD PGGEGTSGEQ QDKPTENNAS
ELKEEVDTLK KENELLKSKL EKAERNQEIL KDVKHRILSL TESKNTLTRE LTTAKAQVQS
LEHVREENEL LKSQFDGRIA RITKEHTDQD KEKADAIARL TRENEQLNIR LNQLTRQLGL
QQGAKPSTSA PGSSEKASAE SPRTANVKPI PGPSAQQSAT VTPRRGSETP LASIRPMSVQ
ASSRTAAVLP TSQSSNNVAI VQGSSSSSSS TNTGSSSVTA LVPPQQQVHT TGSNNNSNES
MSSSPTSSHT DYMPATSSAN VAVAAVPPMG TASTSTAESS SSSQQENESI PAQQPNEPGP
SQVHVSAGQP SQAVALVSPH IEGTPQNSNA VAQSVQSSPQ VQAPPPQEQQ NPAPSTSGTS
SNAQQIHHQA STSSNTVTTS QAAAGHKRPR DVEGDSSTDN VEQPGEKSAP VNKRTRMQGG
ESFQKLQGVT ESGVDVEYQV PTSSQRDQED DIIVVDSEEE GMADEGTADE GTAEADDGPF
EGSEAEEAYE QDEPEMAVNY DEGEGPDIDE DNVQSANNEV DVDDDNEVPN QSGTSSSTTG
AQVAPDAETS STSVGQSSNA GPSTSSDGQA MESSSQPNTS EVQQIQSISS GSGEPSSGPS
TAPSTSSSAG SGSAVAATAS TSSATTSSSA GSSATASSVG SPSQSRRQVN PLARQQQQQL
LLMQQNYEES ADDRIVPSTP TLYVPRRTDG T
//
