ID A0A6I8TX19_AEDAE Unreviewed; 802 AA.
AC A0A6I8TX19;
DT 12-AUG-2020, integrated into UniProtKB/TrEMBL.
DT 12-AUG-2020, sequence version 1.
DT 18-JUN-2025, entry version 21.
DE RecName: Full=Tyrosine-protein kinase {ECO:0000256|PIRNR:PIRNR000632};
DE EC=2.7.10.2 {ECO:0000256|PIRNR:PIRNR000632};
GN Name=5564565 {ECO:0000313|EnsemblMetazoa:AAEL019830-PG};
OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7159 {ECO:0000313|EnsemblMetazoa:AAEL019830-PG, ECO:0000313|Proteomes:UP000008820};
RN [1] {ECO:0000313|EnsemblMetazoa:AAEL019830-PG, ECO:0000313|Proteomes:UP000008820}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LVP_AGWG {ECO:0000313|EnsemblMetazoa:AAEL019830-PG,
RC ECO:0000313|Proteomes:UP000008820};
RG Aedes aegypti Genome Working Group (AGWG);
RA Matthews B.J.;
RT "Aedes aegypti genome working group (AGWG) sequencing and assembly.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AAEL019830-PG}
RP IDENTIFICATION.
RC STRAIN=LVP_AGWG {ECO:0000313|EnsemblMetazoa:AAEL019830-PG};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] +
CC ADP + H(+); Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:20101, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:61978, ChEBI:CHEBI:456216; EC=2.7.10.2;
CC Evidence={ECO:0000256|ARBA:ARBA00051245,
CC ECO:0000256|PIRNR:PIRNR000632};
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC kinase family. Fes/fps subfamily. {ECO:0000256|PIRNR:PIRNR000632}.
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DR AlphaFoldDB; A0A6I8TX19; -.
DR EnsemblMetazoa; AAEL019830-RG; AAEL019830-PG; AAEL019830.
DR EnsemblMetazoa; AAEL019830-RJ; AAEL019830-PJ; AAEL019830.
DR OrthoDB; 546826at2759; -.
DR Proteomes; UP000008820; Chromosome 1.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0002009; P:morphogenesis of an epithelium; IEA:UniProtKB-ARBA.
DR GO; GO:0065008; P:regulation of biological quality; IEA:UniProtKB-ARBA.
DR CDD; cd07657; F-BAR_Fes_Fer; 1.
DR CDD; cd05041; PTKc_Fes_like; 1.
DR CDD; cd10361; SH2_Fps_family; 1.
DR FunFam; 1.10.510.10:FF:000212; Tyrosine-protein kinase; 1.
DR FunFam; 3.30.200.20:FF:000089; Tyrosine-protein kinase; 1.
DR FunFam; 3.30.505.10:FF:000051; Tyrosine-protein kinase; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 3.30.200.20; Phosphorylase Kinase, domain 1; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR035849; Fes/Fps/Fer_SH2.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR050198; Non-receptor_tyrosine_kinases.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR016250; Tyr-prot_kinase_Fes/Fps.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR PANTHER; PTHR24418; TYROSINE-PROTEIN KINASE; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF00017; SH2; 1.
DR PIRSF; PIRSF000632; TyrPK_fps; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00055; FCH; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR PROSITE; PS50001; SH2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR000632};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|PROSITE-
KW ProRule:PRU01077};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|PIRNR:PIRNR000632};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR000632};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000008820};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR000632};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137,
KW ECO:0000256|PIRNR:PIRNR000632}.
FT DOMAIN 1..263
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 438..529
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 541..797
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 335..364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 77..119
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 351..361
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 664
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000632-1"
FT BINDING 547..555
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000632-2"
FT BINDING 571
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000632-2,
FT ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 802 AA; 91897 MW; 4E98E732A2FE91B3 CRC64;
MGFSSALQGR AAHEALLNRQ EAELKLLDTM KRCMIQKSKC DKEYAASLVA VTQQGLKIDR
SDDLQGSHIT RAWRTFMEEL EHTAKLIKSN AEQLESVCLD KLAHLYQDKR RVRKQYQEEH
TKIATKFSHM TEDVARKKSE YQKHLEYYKM LRGRFEEIIK SGRSGRKLDD VIDKYQKACR
KLHLAHNEYV LLLSEAAEIE KDIRTILMPG LLEHQQSQQE AFILTWRNLL QDMSKLGDLT
SDKYSEIQQR IETNISSISP AEEYREFTEK HKTTPTAPVV FQFDESLIED SLGKLQANTL
TVDNLTVDWL KSRQTELESS IKDLQEAQGK LCQEQNGGAV NGGTKPPTPI LNGSNGTSVK
DSSNKNSKEL IALRCQERQM QKQVEMIRAA LNDVGCEELP SGCDDLSTME HLIENKKSVS
QDLSMTLSNN RPLYEEEWFH GVLPREEVVR LLRNEGDFLV RETTRNDESQ TVLSVCWNGH
KHFIVQTTAE GHYRFEGPAF PSIQELILHQ YQSELPVTGR SGAVLRKPVL RERWELSNDD
VILLDKIGRG NFGDVYKAKL KSTKNTLVAV KTCRMTLPEE QKRKFLQEGR ILKQYDHPNI
VKLIGICVQK QPIMIVMELV SGGSLLMFLR KNAATMTQKQ LMAMCRDAAA GMRYLESKNC
IHRDLAARNC LIGNENIVKI SDFGMSREEE EYIVSGGMKQ IPIKWTAPEA LNFGKYTSLC
DVWSYGILVW EIFSRGDTPY SGLSNSRARE RIDEGYRMPA PENTPPEMYR LMLKCWSYEP
ENRPHFDEIF TVVDALMLCA KD
//
