ID A0A6I8U4W6_AEDAE Unreviewed; 1830 AA.
AC A0A6I8U4W6;
DT 12-AUG-2020, integrated into UniProtKB/TrEMBL.
DT 12-AUG-2020, sequence version 1.
DT 02-APR-2025, entry version 17.
DE RecName: Full=Patronin {ECO:0008006|Google:ProtNLM};
GN Name=5573475 {ECO:0000313|EnsemblMetazoa:AAEL026939-PV};
OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7159 {ECO:0000313|EnsemblMetazoa:AAEL026939-PV, ECO:0000313|Proteomes:UP000008820};
RN [1] {ECO:0000313|EnsemblMetazoa:AAEL026939-PV, ECO:0000313|Proteomes:UP000008820}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LVP_AGWG {ECO:0000313|EnsemblMetazoa:AAEL026939-PV,
RC ECO:0000313|Proteomes:UP000008820};
RG Aedes aegypti Genome Working Group (AGWG);
RA Matthews B.J.;
RT "Aedes aegypti genome working group (AGWG) sequencing and assembly.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AAEL026939-PV}
RP IDENTIFICATION.
RC STRAIN=LVP_AGWG {ECO:0000313|EnsemblMetazoa:AAEL026939-PV};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- DOMAIN: The CKK domain binds microtubules. {ECO:0000256|PROSITE-
CC ProRule:PRU00841}.
CC -!- SIMILARITY: Belongs to the CAMSAP1 family. {ECO:0000256|PROSITE-
CC ProRule:PRU00841}.
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DR EnsemblMetazoa; AAEL026939-RV; AAEL026939-PV; AAEL026939.
DR OrthoDB; 2125658at2759; -.
DR Proteomes; UP000008820; Chromosome 3.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0036449; C:microtubule minus-end; IEA:TreeGrafter.
DR GO; GO:0005516; F:calmodulin binding; IEA:InterPro.
DR GO; GO:0051011; F:microtubule minus-end binding; IEA:TreeGrafter.
DR GO; GO:0030507; F:spectrin binding; IEA:InterPro.
DR GO; GO:0031122; P:cytoplasmic microtubule organization; IEA:TreeGrafter.
DR GO; GO:0007026; P:negative regulation of microtubule depolymerization; IEA:TreeGrafter.
DR GO; GO:0031175; P:neuron projection development; IEA:InterPro.
DR FunFam; 3.10.20.360:FF:000002; Patronin, isoform M; 1.
DR Gene3D; 3.10.20.360; CKK domain; 1.
DR InterPro; IPR032940; CAMSAP.
DR InterPro; IPR022613; CAMSAP-like_CH_dom.
DR InterPro; IPR031372; CAMSAP_CC1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR038209; CKK_dom_sf.
DR InterPro; IPR014797; CKK_domain.
DR InterPro; IPR011033; PRC_barrel-like_sf.
DR PANTHER; PTHR21595; PATRONIN; 1.
DR PANTHER; PTHR21595:SF0; PATRONIN; 1.
DR Pfam; PF17095; CAMSAP_CC1; 1.
DR Pfam; PF11971; CAMSAP_CH; 1.
DR Pfam; PF08683; CAMSAP_CKK; 1.
DR SMART; SM01051; CAMSAP_CKK; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF50346; PRC-barrel domain; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS51508; CKK; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701, ECO:0000256|PROSITE-
KW ProRule:PRU00841}; Reference proteome {ECO:0000313|Proteomes:UP000008820}.
FT REGION 360..434
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 463..601
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 720..739
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 993..1050
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1065..1099
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1130..1183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1208..1262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1274..1322
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1388..1418
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1462..1491
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1528..1682
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 802..836
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 370..384
FT /note="Gly residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 414..431
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 463..479
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 508..527
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 572..582
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 993..1005
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1012..1022
FT /note="Gly residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1028..1050
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1065..1077
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1084..1096
FT /note="Gly residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1130..1141
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1145..1156
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1208..1224
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1249..1259
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1281..1293
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1294..1315
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1393..1417
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1528..1538
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1558..1569
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1576..1587
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1592..1607
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1644..1663
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1830 AA; 203685 MW; 8E3535382181D4F6 CRC64;
MDSQQAPQPR SAYDMETQES RFAKQRASVK WLLSKAYNNR VPEFLKDPFY RDHEGQDHLK
PQIVVGLGNA SIYCQVLSNI YSDPNYQSLN HWSILQTLSR KGVPLNESPD LPLTETVLIQ
TNPLRINAHM TVIEALMVLY AKEVASSGRI SSALERISGR SVSQGAQHHE AALLSWISHV
CSALKRRIDY ELTNGVGGGN GGGGGTNPAV DEYGQRLQSP TIAPVRDFRE LCDGVCLAYL
ISYYCPKLVP WHSVKFNHVP TIEDSIHNIL IVSNFSERSL PYSVFHMTPE DITYMRGAMK
QNLVVLLADL FNLFEIHPAK CVCYPGMEQQ QVADSAATNE HGIAHRRGFA THPPILAIPE
LRSGLDSPPG SGGSAGSGGS GNGGAHPRPP FQVTRSPSAS TLRKHVSTRD MHDQQQPQYS
QHPQQSHQPY HQDQDEGFVV HRSKGVPTLS SMQEPLVPAR IRQAKEKTNN DSKAEERGDS
IPAGRPSNWE ENRKQSFSGR RSRRNSLSED SQLTIENFGG SQDQLNTIGR FDRERKTSSA
SLTSVEPVTP ARSSIADARG SIQFGYDTDS SGNEKQDRDT EKPTPALRRH NSTNLHSSSV
ERDIIDGDMS ATHGFGGGSG PAGPVSVADV ETTPRRKTSF ATLPNNTTTW QQQAISVQKM
EDVDDSQSGF EDATKISTIK LKLEEKRRLI EQEKRRMETA WSKQLQTVGK QAFLQAINKQ
GKGGGSMSES DTSKESPESA TMMMVEDSIT SITTTTNTST TVDRAERPCS LQDLDDQNKY
ESKWNAQIIE PKKTPDLENM DLEQYQQSIS KMNSNLHDIQ ADIQRLTQQQ TQIQAQTLQA
QQLLHAQQIA NLLNQQYGSQ QNIQQTIHGT YRPINAQLFG SSPHLPQQNA PLLQQQSPIN
YGTRPPSRDP YLSQQQQLHT LQYVNDQGQY IQQAQQQQQQ QQQHYMGYEN GQYRKENQYS
SNPYLNIDQQ QQQFYQDSNH YRDPYLPQEV KEPPIQQSQQ PQHNQFFLHD SSGGGGGGGG
LGTPPQPAQR RTWAQSAAAA ANQRGSSASS DIQLDINAWN QGIKSSPYNK SPSQSGFSLH
HNGDSGGDGY GTGSRYGGSQ QSFQNLFEVH HGSSSSPQHS RVRNQISQMI NHGGSSNSSP
GAETRNSHHD SFRDNRNMPL SPPIDDMAPQ SISFIGDEDT GDIEINTSKG TSFTLRQQHQ
QDQLEQLYGS SKPGSNKLQH NNGPELNKHL SKLNITSGNR TYRIPSPTRP TLNSNSFHDP
QQDEVNEKGF YISFDNEQPK RPKPPLRTKR SPKKDKLGDG MEHSKESEKP SHRENNQNNF
GTFSVKTANS FSANFNEEQV VSRKSIIDSA SSPFETAATG SSRASNNNMA ATMERDIGER
RHLEDVTNHT STGSNAMNNN NIHHYNNNNG DGYGSENENQ RKAKLVIGND EGNLDPNSVD
EMERKKEKIM LLSLQRRQQA EEAKARKEIE AMQRREKERE KEEERARKKE EQFARRQAIL
EAHKLKKAIE EAEREGKTID RELLIKHQQS QAQLHQSSRG GDGGMHHQTS STPAAKMRPQ
KLSRPRPKTI HVETGSVDLS ETSSLSSRGK KGSNSNLTGI GLHSSNSMRR DYYRGSQDSL
AIRDSDSGLG RATPPRRAPS PGMGPSSRHL PSPSGPGSLP PGLITKRRGF DDGSSDISST
ASSMMDYNGP KLYKQPATKS NRGIILNAVE YCVFPGAVNR EAKQKVLEKI ARSEAKHFLV
LFRDAGCQFR ALYGYWPENE QIIKLYGTGP SQVDDVMFDK FFKYNSGGKC FSQVHTKHLT
VTIDAFTIHN SLWQGKKANL PSKKDMALVI
//
