ID A0A6I8U821_AEDAE Unreviewed; 1864 AA.
AC A0A6I8U821;
DT 12-AUG-2020, integrated into UniProtKB/TrEMBL.
DT 12-AUG-2020, sequence version 1.
DT 18-JUN-2025, entry version 20.
DE RecName: Full=ubiquitinyl hydrolase 1 {ECO:0000256|ARBA:ARBA00012759};
DE EC=3.4.19.12 {ECO:0000256|ARBA:ARBA00012759};
GN Name=5572946 {ECO:0000313|EnsemblMetazoa:AAEL027340-PA};
OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7159 {ECO:0000313|EnsemblMetazoa:AAEL027340-PA, ECO:0000313|Proteomes:UP000008820};
RN [1] {ECO:0000313|EnsemblMetazoa:AAEL027340-PA, ECO:0000313|Proteomes:UP000008820}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LVP_AGWG {ECO:0000313|EnsemblMetazoa:AAEL027340-PA,
RC ECO:0000313|Proteomes:UP000008820};
RG Aedes aegypti Genome Working Group (AGWG);
RA Matthews B.J.;
RT "Aedes aegypti genome working group (AGWG) sequencing and assembly.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AAEL027340-PA}
RP IDENTIFICATION.
RC STRAIN=LVP_AGWG {ECO:0000313|EnsemblMetazoa:AAEL027340-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC residue protein attached to proteins as an intracellular targeting
CC signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707};
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DR FunCoup; A0A6I8U821; 1951.
DR EnsemblMetazoa; AAEL027340-RA; AAEL027340-PA; AAEL027340.
DR EnsemblMetazoa; AAEL027340-RB; AAEL027340-PB; AAEL027340.
DR EnsemblMetazoa; AAEL027340-RD; AAEL027340-PD; AAEL027340.
DR EnsemblMetazoa; AAEL027340-RE; AAEL027340-PE; AAEL027340.
DR EnsemblMetazoa; AAEL027340-RF; AAEL027340-PF; AAEL027340.
DR EnsemblMetazoa; AAEL027340-RG; AAEL027340-PG; AAEL027340.
DR EnsemblMetazoa; AAEL027340-RI; AAEL027340-PI; AAEL027340.
DR InParanoid; A0A6I8U821; -.
DR OrthoDB; 265776at2759; -.
DR Proteomes; UP000008820; Chromosome 3.
DR GO; GO:0005794; C:Golgi apparatus; IEA:TreeGrafter.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:UniProtKB-EC.
DR GO; GO:0016579; P:protein deubiquitination; IEA:InterPro.
DR CDD; cd00051; EFh; 1.
DR FunFam; 3.90.70.10:FF:000080; Ubiquitin carboxyl-terminal hydrolase 15; 1.
DR FunFam; 3.10.20.90:FF:000218; Ubiquitin carboxyl-terminal hydrolase 32; 1.
DR FunFam; 3.90.70.10:FF:000132; Ubiquitin carboxyl-terminal hydrolase 32; 1.
DR FunFam; 1.10.238.10:FF:000444; Ubiquitin carboxyl-terminal hydrolase 6/32; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 2.
DR Gene3D; 3.30.2230.10; DUSP-like; 1.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR Gene3D; 3.10.20.90; Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1; 1.
DR InterPro; IPR035927; DUSP-like_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR006615; Pept_C19_DUSP.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR050185; Ub_carboxyl-term_hydrolase.
DR InterPro; IPR018200; USP_CS.
DR InterPro; IPR028889; USP_dom.
DR PANTHER; PTHR21646; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR PANTHER; PTHR21646:SF76; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 32; 1.
DR Pfam; PF06337; DUSP; 1.
DR Pfam; PF00443; UCH; 2.
DR Pfam; PF25265; USP32_N; 1.
DR SMART; SM00695; DUSP; 1.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF143791; DUSP-like; 1.
DR SUPFAM; SSF47473; EF-hand; 2.
DR PROSITE; PS51283; DUSP; 1.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
DR PROSITE; PS00972; USP_1; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Reference proteome {ECO:0000313|Proteomes:UP000008820}.
FT DOMAIN 265..300
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 301..336
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 424..609
FT /note="DUSP"
FT /evidence="ECO:0000259|PROSITE:PS51283"
FT DOMAIN 791..1826
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
FT REGION 1100..1157
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1273..1318
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1448..1495
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1100..1124
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1277..1289
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1452..1463
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1464..1495
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1864 AA; 207752 MW; B012C4C161EF1D56 CRC64;
MGAKDSRPSC ISYEDAVKRV TDPELRRIKD AFKRSAGTSG TVLSKSAFVQ DVLGDGVPTV
VADWLYAACG GTPKGITFKE LLCGLVLLTK GTQEEKIRFL WNLYCNESGT HILKQEFLKA
IQIETAYQSN VLNTSTIGSS SISNSSSNPI NNNNNQVIVS KNNSLPKYTV ALFGLNDRVT
FEQFKSWIQI YKGATVLSKW LLQDACVNLS SELETPTFYQ SLAGVTHLEE QDIGDLEKVF
WLLKGLALTG QLDLESLGPL ISPPVPKAAL GGVFLAFDEN HDGHIDFKEL CCGVSAACRG
PNVERSKFCF KVFDIDRDGV LNFGEVGKMV DILLFVAKET NAACYKNLTS KQMMGELYQR
ANELCMGSSE TVRECVTIPD PLPEFRFTQE DFLIWSIESN INLVQPFLDL LFEVCHIVLG
LRPQCKHLEG DIVKGWLARE VRRGYKVGQF WYLISSDWWH HWSQYTQPST NSSCVHCKIA
SSYAISRNNA ASAVTGVDEA MICDESFTSN STESMGDLLN TGDSSSLGSG SSGISCGRHP
GGPPGMIDNQ SLIAPILYKQ IPTLTGEGGR LKRDLTLVQH RDFELVPDSL WKALSQWYGG
PLPLPRQVIQ PLSTGDVELE LYPLNLRILR HQIPSPQQQQ NSNSAWSNIS GGYGALTSGS
YSNTSASNVL QPPKKYLAYT AAFSRLATVK QVAEFLCQRL KLRVEDIRLW HLAPTPNGVT
EFPYLLEEDN NTLQELSISD NDQLLLEIRN KDLTWPEELG SLTIAHSNSH NNLERRGTIA
SIQSQHPPGA TGLHNLGNTC FMNAALQVLF NTQPLTQYFI RQMHMYELNM ANKLGTKGQL
AMRYAELLRE VWTASQRSIA PLKLRFCVTK HAPQFSGGGQ HDSQELLDWL LDALHEDLNR
VMEKPYSELK DSDGRADVVV AAEAWNQHHA RNQSIIVDLF YGQLKSKVTC TGCGRDSVRF
DPFSLLSLPL PVENYTYCEV LVTMLDGSVP VKYGLRLNSE MKYWDLKKQL SDLCALDPEL
MLICELSNSQ IRCILANEKK IEPSTACELY VYELPKFDNI LVRSRAGSEL AINIEKGLKD
IQRTPALLLP SIEPSQLTTT SLNTTISSSS NSSSTTVDDT VAITGRRSGP GDNPTKVGTG
SGGAANRKAS GTATTNATTT TASKVSRCFG NTLCMPPNML CFKNIPEISA SPDSTFIFSE
TTQYGASSYA MNTQYKDQNR KTVSTTNLLN NVDNSWNASA VGHDEQDTPC NDCDIIYNGH
GTMEGDSGPF PYADVGHHHH LHQHHHHHQQ QQQHQHGDSF SLSAIKRPPS AGSGSASGMY
HQQKGNYLIA VHRKLSRQDT YFLSHHKSRP GLFGVPLLIP CYDGVTNKEL YCSVWLQVAR
LLSPLPPTPP DQSNHATDCD DSLGYDFPFT LRAVASGGRI CALCPWSRFC RGCEIPCNDE
PLLQGLTYSG RSSSNNSTPN LSSREQTPTF RRKTYGSSTT SSLDGMQSSP TPSMRSINTN
NIQIAIDWDP TALHLRYQST RERLWTEHES VAICRKQQTE PVDLDHCLRA FTSEEKLEQW
YHCSHCKQKK PATKKLQIWK LPPVLIVHLK RFNFVNNKWV KSQKVVNFPY DEFDPTPYLA
SVPQETILRH KELLEGGGTY DGRNHDCHDE IVEFDREMSM IDEVSDEVSI SSITGTIGHV
SDDEDERGQQ VDINSITPAI IGTQPVVTVR QDDDSPSKAK GRLSIKSKGQ RKRLVSSSLT
KTPVIDGQFT DFHKHHLKSE RDPFDLKYQL YAAVCHSGML NGGHYISYAA NPNGSWYCYN
DSSCREIPTR PKIDPSTAYL LFYERRDLDY DPYLPKVDGR QIPPEHLAEF EESENELKKM
CTLM
//
