ID A0A6I8URG0_DROPS Unreviewed; 102 AA.
AC A0A6I8URG0;
DT 12-AUG-2020, integrated into UniProtKB/TrEMBL.
DT 12-AUG-2020, sequence version 1.
DT 18-JUN-2025, entry version 25.
DE RecName: Full=Enhancer of yellow 2 transcription factor {ECO:0000256|HAMAP-Rule:MF_03046};
GN Name=e(y)2b {ECO:0000313|RefSeq:XP_001359738.1};
GN Synonyms=e(y)2 {ECO:0000256|HAMAP-Rule:MF_03046};
OS Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=46245 {ECO:0000313|Proteomes:UP000001819, ECO:0000313|RefSeq:XP_001359738.1};
RN [1] {ECO:0000313|Proteomes:UP000001819}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MV2-25 {ECO:0000313|Proteomes:UP000001819};
RG RefSeq;
RL Submitted (JUN-2024) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_001359738.1}
RP IDENTIFICATION.
RC STRAIN=MV-25-SWS-2005 {ECO:0000313|RefSeq:XP_001359738.1};
RC TISSUE=Whole body {ECO:0000313|RefSeq:XP_001359738.1};
RG RefSeq;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- FUNCTION: Involved in mRNA export coupled transcription activation by
CC association with both the AMEX and the SAGA complexes. The SAGA complex
CC is a multiprotein complex that activates transcription by remodeling
CC chromatin and mediating histone acetylation and deubiquitination.
CC Within the SAGA complex, participates to a subcomplex that specifically
CC deubiquitinates histone H2B. The SAGA complex is recruited to specific
CC gene promoters by activators, where it is required for transcription.
CC Required for nuclear receptor-mediated transactivation. Involved in
CC transcription elongation by recruiting the THO complex onto nascent
CC mRNA. The AMEX complex functions in docking export-competent
CC ribonucleoprotein particles (mRNPs) to the nuclear entrance of the
CC nuclear pore complex (nuclear basket). AMEX participates in mRNA export
CC and accurate chromatin positioning in the nucleus by tethering genes to
CC the nuclear periphery. {ECO:0000256|HAMAP-Rule:MF_03046}.
CC -!- SUBUNIT: Component of the nuclear pore complex (NPC)-associated AMEX
CC complex (anchoring and mRNA export complex), composed of at least e(y)2
CC and xmas-2. Component of the SAGA transcription coactivator-HAT
CC complexes, at least composed of Ada2b, e(y)2, Pcaf/Gcn5, Taf10 and
CC Nipped-A/Trrap. Within the SAGA complex, e(y)2, Sgf11, and not/nonstop
CC form an additional subcomplex of SAGA called the DUB module
CC (deubiquitination module). Component of the THO complex, composed of at
CC least e(y)2, HPR1, THO2, THOC5, THOC6 and THOC7. Interacts with e(y)1.
CC Interacts with su(Hw) (via zinc fingers). Interacts with xmas-2;
CC required for localization to the nuclear periphery. Interacts with the
CC nuclear pore complex (NPC). {ECO:0000256|HAMAP-Rule:MF_03046}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000256|HAMAP-
CC Rule:MF_03046}. Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03046}.
CC -!- SIMILARITY: Belongs to the ENY2 family. {ECO:0000256|HAMAP-
CC Rule:MF_03046}.
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DR RefSeq; XP_001359738.1; XM_001359701.3.
DR AlphaFoldDB; A0A6I8URG0; -.
DR FunCoup; A0A6I8URG0; 10.
DR EnsemblMetazoa; FBtr0286280; FBpp0284718; FBgn0073149.
DR KEGG; dpo:4802914; -.
DR CTD; 50143; -.
DR InParanoid; A0A6I8URG0; -.
DR OMA; CGWRKDI; -.
DR Proteomes; UP000001819; Chromosome 2.
DR Bgee; FBgn0073149; Expressed in male reproductive system and 2 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0071819; C:DUBm complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005643; C:nuclear pore; IEA:UniProtKB-UniRule.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0000124; C:SAGA complex; IEA:UniProtKB-UniRule.
DR GO; GO:0070390; C:transcription export complex 2; IEA:UniProtKB-UniRule.
DR GO; GO:0043035; F:chromatin insulator sequence binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003713; F:transcription coactivator activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0006406; P:mRNA export from nucleus; IEA:UniProtKB-UniRule.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0006368; P:transcription elongation by RNA polymerase II; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.246.140; -; 1.
DR HAMAP; MF_03046; ENY2_Sus1; 1.
DR InterPro; IPR018783; TF_ENY2.
DR InterPro; IPR038212; TF_EnY2_sf.
DR PANTHER; PTHR12514; ENHANCER OF YELLOW 2 TRANSCRIPTION FACTOR; 1.
DR Pfam; PF10163; EnY2; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|HAMAP-Rule:MF_03046};
KW Chromatin regulator {ECO:0000256|HAMAP-Rule:MF_03046};
KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03046};
KW mRNA transport {ECO:0000256|HAMAP-Rule:MF_03046};
KW Nucleus {ECO:0000256|HAMAP-Rule:MF_03046};
KW Protein transport {ECO:0000256|HAMAP-Rule:MF_03046};
KW Reference proteome {ECO:0000313|Proteomes:UP000001819};
KW Transcription {ECO:0000256|HAMAP-Rule:MF_03046};
KW Transcription regulation {ECO:0000256|HAMAP-Rule:MF_03046};
KW Translocation {ECO:0000256|HAMAP-Rule:MF_03046};
KW Transport {ECO:0000256|HAMAP-Rule:MF_03046}.
SQ SEQUENCE 102 AA; 11673 MW; 153812D4DFAEE617 CRC64;
MSSSKEIGTD AQAKEDVKLT NTESVALKDL LQTRLDECGW RKQVEQNIRE IIAAKERDMQ
TLTSEELEAE IAPKARAMVP EYVRKEMLLR VREALESSLP RK
//
