ID A0A6I8VF12_DROPS Unreviewed; 419 AA.
AC A0A6I8VF12;
DT 12-AUG-2020, integrated into UniProtKB/TrEMBL.
DT 12-AUG-2020, sequence version 1.
DT 28-JAN-2026, entry version 24.
DE RecName: Full=Proteasomal ubiquitin receptor ADRM1 homolog {ECO:0000256|ARBA:ARBA00070663};
GN Name=Rpn13 {ECO:0000313|RefSeq:XP_015039898.1};
OS Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=46245 {ECO:0000313|Proteomes:UP000001819, ECO:0000313|RefSeq:XP_015039898.1};
RN [1] {ECO:0000313|Proteomes:UP000001819}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MV2-25 {ECO:0000313|Proteomes:UP000001819};
RG RefSeq;
RL Submitted (JUN-2024) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_015039898.1}
RP IDENTIFICATION.
RC STRAIN=MV-25-SWS-2005 {ECO:0000313|RefSeq:XP_015039898.1};
RC TISSUE=Whole body {ECO:0000313|RefSeq:XP_015039898.1};
RG RefSeq;
RL Submitted (AUG-2025) to UniProtKB.
CC -!- FUNCTION: May function as a proteasomal ubiquitin receptor. May promote
CC the deubiquitinating activity associated with the 26S proteasome.
CC {ECO:0000256|ARBA:ARBA00054744}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the ADRM1 family.
CC {ECO:0000256|ARBA:ARBA00009216}.
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DR RefSeq; XP_015039898.1; XM_015184412.2.
DR AlphaFoldDB; A0A6I8VF12; -.
DR FunCoup; A0A6I8VF12; 1436.
DR GeneID; 4804377; -.
DR KEGG; dpo:4804377; -.
DR InParanoid; A0A6I8VF12; -.
DR Proteomes; UP000001819; Chromosome 3.
DR Bgee; FBgn0072270; Expressed in female reproductive system and 3 other cell types or tissues.
DR ExpressionAtlas; A0A6I8VF12; baseline.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0008541; C:proteasome regulatory particle, lid subcomplex; IEA:TreeGrafter.
DR GO; GO:0061133; F:endopeptidase activator activity; IEA:TreeGrafter.
DR GO; GO:0070628; F:proteasome binding; IEA:TreeGrafter.
DR CDD; cd13314; PH_Rpn13; 1.
DR FunFam; 2.30.29.70:FF:000001; Proteasomal ubiquitin receptor ADRM1; 1.
DR FunFam; 1.10.2020.20:FF:000003; Proteasomal ubiquitin receptor ADRM1 homolog; 1.
DR Gene3D; 1.10.2020.20; -; 1.
DR Gene3D; 2.30.29.70; Proteasomal ubiquitin receptor Rpn13/ADRM1; 1.
DR InterPro; IPR044867; DEUBAD_dom.
DR InterPro; IPR006773; Rpn13/ADRM1.
DR InterPro; IPR044868; Rpn13/ADRM1_Pru.
DR InterPro; IPR038633; Rpn13/ADRM1_Pru_sf.
DR InterPro; IPR032368; RPN13_DEUBAD.
DR InterPro; IPR038108; RPN13_DEUBAD_sf.
DR PANTHER; PTHR12225; ADHESION REGULATING MOLECULE 1 110 KDA CELL MEMBRANE GLYCOPROTEIN; 1.
DR PANTHER; PTHR12225:SF0; PROTEASOMAL UBIQUITIN RECEPTOR ADRM1; 1.
DR Pfam; PF04683; Rpn13_ADRM1_Pru; 1.
DR Pfam; PF16550; RPN13_C; 1.
DR PROSITE; PS51916; DEUBAD; 1.
DR PROSITE; PS51917; PRU; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Proteasome {ECO:0000256|ARBA:ARBA00022942};
KW Receptor {ECO:0000313|RefSeq:XP_015039898.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001819}.
FT DOMAIN 12..125
FT /note="Pru"
FT /evidence="ECO:0000259|PROSITE:PS51917"
FT DOMAIN 273..387
FT /note="DEUBAD"
FT /evidence="ECO:0000259|PROSITE:PS51916"
FT REGION 122..143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 169..253
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 382..419
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 169..192
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 193..203
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 209..253
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 389..419
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 419 AA; 45249 MW; B613723B5B40D70B CRC64;
MFGRQSGLGS SSNSSNLVEF RAGRMNMVGK MVHPDSRKGS VYMTQSDDGL MHFCWKDRTS
GKVEDDLIVF PDDFEYKRVE QCKTGRVYVL KFKSSTRRMF FWMQEPKTDK DEEHCRRINE
LLNNPPSAHQ RGGGGGSNDG DLQYMLNNMS QQQLMQLFGG VGQMGGLSSL LGQMNSRTPS
SRNTSSSGGA SALQTPENIS VPRTPTAPKG SKSGSSRSNL NSQSDTAGSA SSSIDADASG
KNSTTSTTTA SETTGAYANP FQAYLSNLSP EHGAGRSLNI DLSTALSGAE AINQLIADPE
RVKTLIVHLP ESENADEDRK QQIKDHITSP QFQQALAQFS NALQSAQLGP VVKQFELSND
AVAAAYSGNL EDFVNALQKS LPAGTTMGGE KEATEKKAEP EAAKDDNPEP VEKPEEKQK
//
