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Database: UniProt
Entry: A0A6I9HE44_GEOFO
LinkDB: A0A6I9HE44_GEOFO
Original site: A0A6I9HE44_GEOFO 
ID   A0A6I9HE44_GEOFO        Unreviewed;      1312 AA.
AC   A0A6I9HE44;
DT   07-OCT-2020, integrated into UniProtKB/TrEMBL.
DT   07-OCT-2020, sequence version 1.
DT   18-JUN-2025, entry version 24.
DE   SubName: Full=DNA repair protein RAD50 {ECO:0000313|RefSeq:XP_005418732.1};
GN   Name=RAD50 {ECO:0000313|RefSeq:XP_005418732.1};
OS   Geospiza fortis (Medium ground-finch).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Australaves;
OC   Passeriformes; Thraupidae; Geospiza.
OX   NCBI_TaxID=48883 {ECO:0000313|Proteomes:UP000504602, ECO:0000313|RefSeq:XP_005418732.1};
RN   [1] {ECO:0000313|RefSeq:XP_005418732.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (MAR-2025) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + phosphate + H(+); Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216;
CC         Evidence={ECO:0000256|ARBA:ARBA00049360};
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- SUBCELLULAR LOCATION: Chromosome, telomere
CC       {ECO:0000256|ARBA:ARBA00004574}. Nucleus
CC       {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the SMC family. RAD50 subfamily.
CC       {ECO:0000256|ARBA:ARBA00009439}.
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DR   RefSeq; XP_005418732.1; XM_005418675.2.
DR   Ensembl; ENSGFOT00000001894; ENSGFOP00000001862; ENSGFOG00000001305.
DR   GeneID; 102037092; -.
DR   KEGG; gfr:102037092; -.
DR   CTD; 10111; -.
DR   InParanoid; A0A6I9HE44; -.
DR   OrthoDB; 18797at2759; -.
DR   Proteomes; UP000504602; Unplaced.
DR   GO; GO:0070533; C:BRCA1-C complex; IEA:Ensembl.
DR   GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR   GO; GO:0000794; C:condensed nuclear chromosome; IEA:TreeGrafter.
DR   GO; GO:0030870; C:Mre11 complex; IEA:Ensembl.
DR   GO; GO:0035861; C:site of double-strand break; IEA:Ensembl.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:Ensembl.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:Ensembl.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:Ensembl.
DR   GO; GO:0003691; F:double-stranded telomeric DNA binding; IEA:TreeGrafter.
DR   GO; GO:0051880; F:G-quadruplex DNA binding; IEA:TreeGrafter.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0043539; F:protein serine/threonine kinase activator activity; IEA:Ensembl.
DR   GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:Ensembl.
DR   GO; GO:0000014; F:single-stranded DNA endodeoxyribonuclease activity; IEA:Ensembl.
DR   GO; GO:0043047; F:single-stranded telomeric DNA binding; IEA:TreeGrafter.
DR   GO; GO:0070192; P:chromosome organization involved in meiotic cell cycle; IEA:TreeGrafter.
DR   GO; GO:0000729; P:DNA double-strand break processing; IEA:Ensembl.
DR   GO; GO:0110025; P:DNA strand resection involved in replication fork processing; IEA:Ensembl.
DR   GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:Ensembl.
DR   GO; GO:1904354; P:negative regulation of telomere capping; IEA:Ensembl.
DR   GO; GO:2000781; P:positive regulation of double-strand break repair; IEA:Ensembl.
DR   GO; GO:0032206; P:positive regulation of telomere maintenance; IEA:Ensembl.
DR   GO; GO:0062176; P:R-loop processing; IEA:Ensembl.
DR   GO; GO:0000019; P:regulation of mitotic recombination; IEA:Ensembl.
DR   GO; GO:0000722; P:telomere maintenance via recombination; IEA:TreeGrafter.
DR   GO; GO:0007004; P:telomere maintenance via telomerase; IEA:Ensembl.
DR   GO; GO:0031860; P:telomeric 3' overhang formation; IEA:Ensembl.
DR   FunFam; 3.40.50.300:FF:001037; DNA repair protein RAD50; 1.
DR   FunFam; 3.40.50.300:FF:001065; DNA repair protein RAD50 isoform X1; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR038729; Rad50/SbcC_AAA.
DR   InterPro; IPR004584; Rad50_eukaryotes.
DR   InterPro; IPR013134; Zn_hook_RAD50.
DR   NCBIfam; TIGR00606; rad50; 1.
DR   PANTHER; PTHR18867:SF12; DNA REPAIR PROTEIN RAD50; 1.
DR   PANTHER; PTHR18867; RAD50; 1.
DR   Pfam; PF13476; AAA_23; 1.
DR   Pfam; PF04423; Rad50_zn_hook; 1.
DR   Pfam; PF13558; SbcC_Walker_B; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF75712; Rad50 coiled-coil Zn hook; 1.
DR   SUPFAM; SSF46966; Spectrin repeat; 1.
DR   PROSITE; PS51131; ZN_HOOK; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW   Meiosis {ECO:0000256|ARBA:ARBA00023254};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW   ProRule:PRU00471}; Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000504602};
KW   Telomere {ECO:0000256|ARBA:ARBA00022895};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00471}.
FT   DOMAIN          635..734
FT                   /note="Zinc-hook"
FT                   /evidence="ECO:0000259|PROSITE:PS51131"
FT   COILED          203..233
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          265..349
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          450..607
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          635..662
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          712..822
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          853..1070
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   BINDING         681
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00471"
FT   BINDING         684
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00471"
SQ   SEQUENCE   1312 AA;  153426 MW;  35CFB95B6E9DBA6A CRC64;
     MSRIEKMSIL GVRSFGIEDK DKQIITFFNP LTILVGPNGA GKTTIIECLK YISTGDFPPG
     TKGKTFVHDP KIANETDVRA QIRLQFRDVN GEVMAVQRSM VCTQKSKEPE FKTLESVITR
     TKHGEKVSLS SKCAEIDREM INALGVSKAV LNNVIFCHQE ESNWPLSEGK ALKQKFDEIF
     SATRYIKALE ALRQVRLKQS LKVKECQTEL KYLKQNKEKA QEIQDHLSNR EAQLAASKEN
     VISIENQLEP LKNSLAVVEQ NLTKVMRLDN DVKALESRKR QMEKDNQDLQ QKMEKVFQGT
     DEQLRDRYQN HQRIVKEKEK RLLDCKRDLD RATKECQRFN SEKSELLIER GRLQLQADRH
     QEHIVTRDSL VQSLAAQLEL DGFERAPFTD RHIASFHRLV KDRQDRDTEA ANRMMREFAQ
     KETMKQKQID EIRDKKTGLE RTIDLKSDIQ NKKQAELKNV KRELQQLEGF SDRISELDEE
     IGKMEHDLET AERNSNIETL EQEVQTLQNE KINLDKALRR LDQEMEQLNL HTTTITQLEM
     LKKDKAEKED QIRKVKSRHS EELTSLLGYF PNKKQLEDWL HGKNKKINQT RDTLANLNKR
     LSSVEYDKTY ASNELKKKEA QLSSHEAKLF DVCGSQDFDS DLNKLQDEIE KSSKQRAVLA
     GATAVYSQFI TQLTEENQSC CPVCQRVFQT EAELQDVISD LQSKLRLAPD KLKSTESELK
     RKEKKRDEMM SLKPLRQTVV ELQDKEIPDL RNKIQNANRD LTGLKGEIEE QESLLQTALS
     EEEGAKARLQ DITLMERYQT DIRDVERKIA QQEAKLLCVN LNRTVLQVSR EKQEKKQLWD
     TVTSKIELNQ KHKQDQQSQI QQLKSAVNEL KAEKLQIVSS MQRRRQLEEQ TVELTTEVQS
     LCREIKEAEE QILPLEAKLD KLQHEKEELV NKRTASNKET QEKMNNINEK VKDINKYVKE
     IENYIQQGKE DYKKQKESEL EEVNSRLAAC EKQKEKISKE MEMTRQDIDT QKIQERWLED
     NLTLRKRNEE LKEVEDNIKK LMKEMGEMKV PQMKNEQKHL EEKIESLKRN HHVALGRQRG
     FEEEIVRFRK ELREPQFRDA EEKYRDMMIV MRTTELVNKD LDLYYKALDK AIMTFHSMKM
     EEINKIIRDL WRSIYRGQDI EYIEIRSDAD ENVSATDKRR NYNYRVVMVK GDTALDMRGR
     CSAGQKVLAS LIIRLALAET FCINCGILAL DEPTTNLDRE NIESLAHALV EIIKSRLHQR
     NFQLLVITHD EDFVELLGRS EYVETFYRIK KNIDQCSEIM KCSVSSLGSY VH
//
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