ID A0A6I9HRE6_GEOFO Unreviewed; 214 AA.
AC A0A6I9HRE6;
DT 07-OCT-2020, integrated into UniProtKB/TrEMBL.
DT 07-OCT-2020, sequence version 1.
DT 28-JAN-2026, entry version 25.
DE RecName: Full=Insulin-like growth factor 2 {ECO:0000256|ARBA:ARBA00049761};
DE AltName: Full=Insulin-like growth factor II {ECO:0000256|ARBA:ARBA00049823};
GN Name=IGF2 {ECO:0000313|RefSeq:XP_005427277.2};
OS Geospiza fortis (Medium ground-finch).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Australaves;
OC Passeriformes; Thraupidae; Geospiza.
OX NCBI_TaxID=48883 {ECO:0000313|Proteomes:UP000504602, ECO:0000313|RefSeq:XP_005427277.2};
RN [1] {ECO:0000313|RefSeq:XP_005427277.2}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (AUG-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU000406}.
CC -!- SIMILARITY: Belongs to the insulin family.
CC {ECO:0000256|ARBA:ARBA00009034, ECO:0000256|RuleBase:RU000406}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_005427277.2; XM_005427220.3.
DR AlphaFoldDB; A0A6I9HRE6; -.
DR FunCoup; A0A6I9HRE6; 54.
DR GeneID; 102032627; -.
DR KEGG; gfr:102032627; -.
DR CTD; 3481; -.
DR InParanoid; A0A6I9HRE6; -.
DR OrthoDB; 9449995at2759; -.
DR Proteomes; UP000504602; Unplaced.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR GO; GO:0005159; F:insulin-like growth factor receptor binding; IEA:TreeGrafter.
DR GO; GO:0043539; F:protein serine/threonine kinase activator activity; IEA:TreeGrafter.
DR GO; GO:0042104; P:positive regulation of activated T cell proliferation; IEA:TreeGrafter.
DR GO; GO:0046628; P:positive regulation of insulin receptor signaling pathway; IEA:TreeGrafter.
DR GO; GO:0043410; P:positive regulation of MAPK cascade; IEA:TreeGrafter.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:TreeGrafter.
DR GO; GO:1905564; P:positive regulation of vascular endothelial cell proliferation; IEA:TreeGrafter.
DR GO; GO:0051147; P:regulation of muscle cell differentiation; IEA:TreeGrafter.
DR CDD; cd04368; IlGF; 1.
DR FunFam; 1.10.100.10:FF:000002; Insulin-like growth factor II preproprotein; 1.
DR Gene3D; 1.10.100.10; Insulin-like; 1.
DR InterPro; IPR022350; IGF-1/2.
DR InterPro; IPR022334; IGF2.
DR InterPro; IPR013576; IGF2_C.
DR InterPro; IPR022352; Ins/IGF/rlx.
DR InterPro; IPR016179; Insulin-like.
DR InterPro; IPR036438; Insulin-like_sf.
DR InterPro; IPR022353; Insulin_CS.
DR PANTHER; PTHR46886; INSULIN-LIKE GROWTH FACTOR II; 1.
DR PANTHER; PTHR46886:SF1; INSULIN-LIKE GROWTH FACTOR II; 1.
DR Pfam; PF08365; IGF2_C; 1.
DR Pfam; PF00049; Insulin; 2.
DR PRINTS; PR02002; INSLNLIKEGF.
DR PRINTS; PR02006; INSLNLIKEGF2.
DR PRINTS; PR00276; INSULINFAMLY.
DR SMART; SM00078; IlGF; 1.
DR SUPFAM; SSF56994; Insulin-like; 1.
DR PROSITE; PS00262; INSULIN; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR622350-50};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030};
KW Reference proteome {ECO:0000313|Proteomes:UP000504602};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|RuleBase:RU000406};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 42..97
FT /note="Insulin-like"
FT /evidence="ECO:0000259|SMART:SM00078"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 177..214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 182..199
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 45..84
FT /evidence="ECO:0000256|PIRSR:PIRSR622350-50"
FT DISULFID 57..97
FT /evidence="ECO:0000256|PIRSR:PIRSR622350-50"
FT DISULFID 83..88
FT /evidence="ECO:0000256|PIRSR:PIRSR622350-50"
SQ SEQUENCE 214 AA; 23570 MW; 6376440A18B22333 CRC64;
MSSAGAHTDE RCRQPAFLPG PPPPQDVESS RRDSAAAYGT AETLCGGELV DTLQFVCGDR
GFYFSRPVGR NNRRINRGIV EECCFRSCDL ALLETYCAKS VKSERDLSAT SLAGLPALSK
ESFQKPSHGK YSKYDVWQKK SAQRRQRDVP NILRALQYRW QAEGLQAAEA AKALHRPLIS
LPSQRPPAAR ASPAPSRRSG PNQTTDTLGH DHMS
//
