ID A0A6I9KXN4_PERMB Unreviewed; 272 AA.
AC A0A6I9KXN4;
DT 07-OCT-2020, integrated into UniProtKB/TrEMBL.
DT 07-OCT-2020, sequence version 1.
DT 28-JAN-2026, entry version 24.
DE RecName: Full=Insulin-like growth factor-binding protein 1 {ECO:0000256|ARBA:ARBA00013675};
GN Name=Igfbp1 {ECO:0000313|Ensembl:ENSPEMP00000013500.1};
OS Peromyscus maniculatus bairdii (Prairie deer mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Neotominae; Peromyscus.
OX NCBI_TaxID=230844 {ECO:0000313|Ensembl:ENSPEMP00000013500.1, ECO:0000313|Proteomes:UP000694547};
RN [1] {ECO:0000313|Ensembl:ENSPEMP00000013500.1, ECO:0000313|Proteomes:UP000694547}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lassance J.-M., Hoekstra H.E.;
RT "Improved assembly of the deer mouse Peromyscus maniculatus genome.";
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPEMP00000013500.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [3] {ECO:0000313|Ensembl:ENSPEMP00000013500.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- SUBUNIT: Binds equally well IGF1 and IGF2. Interacts with integrin
CC ITGA5:ITGB1. Interacts with VHL; this interaction inhibits HIF1A
CC degradation. {ECO:0000256|ARBA:ARBA00049694}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00500}.
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DR RefSeq; XP_006973076.1; XM_006973014.3.
DR AlphaFoldDB; A0A6I9KXN4; -.
DR Ensembl; ENSPEMT00000017740.2; ENSPEMP00000013500.1; ENSPEMG00000013560.2.
DR GeneID; 102907785; -.
DR CTD; 3484; -.
DR GeneTree; ENSGT00940000157394; -.
DR OrthoDB; 9926277at2759; -.
DR Proteomes; UP000694547; Chromosome 10.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0031994; F:insulin-like growth factor I binding; IEA:Ensembl.
DR GO; GO:0031995; F:insulin-like growth factor II binding; IEA:Ensembl.
DR GO; GO:0043567; P:regulation of insulin-like growth factor receptor signaling pathway; IEA:TreeGrafter.
DR GO; GO:0032868; P:response to insulin; IEA:Ensembl.
DR CDD; cd00191; TY; 1.
DR FunFam; 4.10.40.20:FF:000001; Insulin-like growth factor binding protein 5; 1.
DR FunFam; 4.10.800.10:FF:000002; Insulin-like growth factor-binding protein 2; 1.
DR Gene3D; 4.10.40.20; -; 1.
DR Gene3D; 4.10.800.10; Thyroglobulin type-1; 1.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR000867; IGFBP-like.
DR InterPro; IPR022322; IGFBP1.
DR InterPro; IPR022321; IGFBP_1-6_chordata.
DR InterPro; IPR017891; Insulin_GF-bd_Cys-rich_CS.
DR InterPro; IPR000716; Thyroglobulin_1.
DR InterPro; IPR036857; Thyroglobulin_1_sf.
DR PANTHER; PTHR11551; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN; 1.
DR PANTHER; PTHR11551:SF6; INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 1; 1.
DR Pfam; PF00219; IGFBP; 1.
DR Pfam; PF00086; Thyroglobulin_1; 1.
DR PRINTS; PR01976; IGFBPFAMILY.
DR PRINTS; PR01977; IGFBPFAMILY1.
DR SMART; SM00121; IB; 1.
DR SMART; SM00211; TY; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF57610; Thyroglobulin type-1 domain; 1.
DR PROSITE; PS00222; IGFBP_N_1; 1.
DR PROSITE; PS51323; IGFBP_N_2; 1.
DR PROSITE; PS00484; THYROGLOBULIN_1_1; 1.
DR PROSITE; PS51162; THYROGLOBULIN_1_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Growth factor binding {ECO:0000256|ARBA:ARBA00023183};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000694547};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..272
FT /note="Insulin-like growth factor-binding protein 1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5044634832"
FT DOMAIN 28..109
FT /note="IGFBP N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51323"
FT DOMAIN 186..264
FT /note="Thyroglobulin type-1"
FT /evidence="ECO:0000259|PROSITE:PS51162"
FT REGION 116..140
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 272 AA; 29608 MW; E9289AD7C682C2D3 CRC64;
MPEFLAVVPW RFLILLAFQV GVATGDAQPW RCAPCTAESL GLCPPVPASC PEISRPAGCG
CCPTCALPLG AACGVATARC AQGLSCRALP GEPRPLHALT RGQGACVPEP AAPATRAVSS
SELEEAKATV APEDELPESP EMTEEQLLES FHLMAPSNED RPILWNAIST YNSIRAREIA
NLKKWKEPCR RELYKVLERL AAAQQKAGDE IYKFYLPNCN KNGFYHSKQC ETSLDGEAGL
CWCVYPWSGK KIPGSLETRG DPNCHQYFNV QN
//
