ID A0A6I9PJU7_9TELE Unreviewed; 395 AA.
AC A0A6I9PJU7;
DT 07-OCT-2020, integrated into UniProtKB/TrEMBL.
DT 07-OCT-2020, sequence version 1.
DT 28-JAN-2026, entry version 23.
DE SubName: Full=Suppressor of cytokine signaling 4 {ECO:0000313|RefSeq:XP_010791339.1};
GN Name=socs4 {ECO:0000313|RefSeq:XP_010791339.1};
OS Notothenia coriiceps (black rockcod).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Notothenioidei; Nototheniidae; Notothenia.
OX NCBI_TaxID=8208 {ECO:0000313|Proteomes:UP000504611, ECO:0000313|RefSeq:XP_010791339.1};
RN [1] {ECO:0000313|RefSeq:XP_010791339.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_010791339.1};
RG RefSeq;
RL Submitted (AUG-2025) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR RefSeq; XP_010791339.1; XM_010793037.1.
DR AlphaFoldDB; A0A6I9PJU7; -.
DR KEGG; ncc:104964293; -.
DR CTD; 122809; -.
DR OrthoDB; 8820570at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000504611; Unplaced.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF35; SUPPRESSOR OF CYTOKINE SIGNALING 4 ISOFORM X1; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000504611};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 249..344
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 339..388
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 27..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 395 AA; 45018 MW; 12F1BC79A300549C CRC64;
MSDKKPRGSD TRPKSGFRSW SADSYVWRGK KRSRSSRNGS SPGGMEVEGT EELGVRSTSC
PRRRRERKCS CSTLGEALTS ADIDVVCRKA LSHRSLRQRF QDAVGQCFPL RSHHHHHHHH
HHSLGSSRPF SVLFWSKRKI HVSELMQEKC PFSPKSELAR CWHLIKNQAT NQNALMDMEI
PLKPNVSTSS TSPPTTPLSW DDICCSPGPG GTSLEDWDPS CSHGEAEGSC GHTDYILVPD
LLQINNSSCY WGVLNRFEAE ELLEGKPEGT FLLRDSAQDE FLFSVSFRRY SRSLHARIEQ
NDKRFSFDVR DPCMYRDPSV TGLLRHYSDP ATCLFFEPLL SRPLPRTFPF TLQHLCRTVI
CSHITYQGID NLMLPYQLRD FLRQYHIKCD GACAV
//
