ID A0A6I9PZ76_9TELE Unreviewed; 1216 AA.
AC A0A6I9PZ76;
DT 07-OCT-2020, integrated into UniProtKB/TrEMBL.
DT 07-OCT-2020, sequence version 1.
DT 28-JAN-2026, entry version 23.
DE SubName: Full=Collagen type XVIII alpha 1 chain a {ECO:0000313|RefSeq:XP_010790536.1};
GN Name=col18a1a {ECO:0000313|RefSeq:XP_010790536.1};
OS Notothenia coriiceps (black rockcod).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Notothenioidei; Nototheniidae; Notothenia.
OX NCBI_TaxID=8208 {ECO:0000313|Proteomes:UP000504611, ECO:0000313|RefSeq:XP_010790536.1};
RN [1] {ECO:0000313|RefSeq:XP_010790536.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_010790536.1};
RG RefSeq;
RL Submitted (AUG-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
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DR RefSeq; XP_010790536.1; XM_010792234.1.
DR AlphaFoldDB; A0A6I9PZ76; -.
DR KEGG; ncc:104963624; -.
DR CTD; 564123; -.
DR OrthoDB; 5983381at2759; -.
DR Proteomes; UP000504611; Unplaced.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR GO; GO:0031012; C:extracellular matrix; IEA:TreeGrafter.
DR GO; GO:0005615; C:extracellular space; IEA:TreeGrafter.
DR GO; GO:0030020; F:extracellular matrix structural constituent conferring tensile strength; IEA:TreeGrafter.
DR GO; GO:0030198; P:extracellular matrix organization; IEA:TreeGrafter.
DR CDD; cd00247; Endostatin-like; 1.
DR FunFam; 3.10.100.10:FF:000008; collagen alpha-1(XVIII) chain isoform X1; 1.
DR FunFam; 3.40.1620.70:FF:000003; Collagen type XVIII alpha 1; 1.
DR Gene3D; 3.40.1620.70; -; 1.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR050149; Collagen_superfamily.
DR InterPro; IPR010515; Collagenase_NC10/endostatin.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR045463; XV/XVIII_trimerization_dom.
DR PANTHER; PTHR24023; COLLAGEN ALPHA; 1.
DR PANTHER; PTHR24023:SF1082; COLLAGEN TRIPLE HELIX REPEAT; 1.
DR Pfam; PF01391; Collagen; 5.
DR Pfam; PF20010; Collagen_trimer; 1.
DR Pfam; PF06482; Endostatin; 1.
DR SUPFAM; SSF56436; C-type lectin-like; 1.
PE 4: Predicted;
KW Collagen {ECO:0000256|ARBA:ARBA00023119,
KW ECO:0000313|RefSeq:XP_010790536.1};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Reference proteome {ECO:0000313|Proteomes:UP000504611};
KW Secreted {ECO:0000256|ARBA:ARBA00022530}.
FT DOMAIN 882..928
FT /note="Collagen type XV/XVIII trimerization"
FT /evidence="ECO:0000259|Pfam:PF20010"
FT DOMAIN 1042..1210
FT /note="Collagenase NC10/endostatin"
FT /evidence="ECO:0000259|Pfam:PF06482"
FT REGION 72..754
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 773..880
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 952..1036
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 108..123
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 125..142
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 160..175
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 181..190
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 196..208
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 225..235
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 266..275
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 304..313
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 353..363
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 364..380
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 423..432
FT /note="Gly residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 495..511
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 540..552
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 631..643
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 691..701
FT /note="Gly residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 706..718
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 773..783
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 819..828
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 839..873
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 975..991
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 994..1008
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1023..1034
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1216 AA; 123343 MW; 955A5714EB608FFB CRC64;
MKCEERGGMK GSPDVALRDG SIPADLRVLL NAAPLSRDPS PTLSLQNHRL GIQQAETIQG
VIGELRIVGD PRAAERHCEE DGDDSDMASG DGSGDEERNS RPAGETLRWT TTPPSSRPIQ
QPPLSKKDEV LTERDTASDS RHSSVSVENR PGLPGSSGAK GEKGSQGDSG LKGDRGPIGP
KGETTSSSGS GSRGGSRGEK GELGEKGLKG SAGFGYIGKK GEPGPAGPVG PPGPPGAATE
VTVGGDGSVA SRTPGPRGPA GPPGTSGPEG PPGTDGEPGD PGEDGKTGLE GPPGFPGTPG
DPGLKGDKGD RGDGQPGPRG PPGLPGPGIR STFVDMEGSG FPDLESVRGL PGLPGPPGPP
GSPGPSTTGT ASSSGAFGPP GKDGAAGQPG LPGIPGTDGS PGASAPKGEK GDAGELGLPG
AIGQKGSGGD PGVKGDPGET GLAGLPGPLG PVGKPGPPGP PGSSYRVGFD DMEASGGGFS
NGLPGARGPE GRQGSSGLPG LPGKSGLPGI PGQKGSEGSL GRDGQPGLDG FPGPQGPKGD
GGDKGDRGEP GRDGSGLTGP PGPPGPPGQI IYQTDGNAGG VAGDVGRAGE NGLPGQAGFP
GPIGPRGDRG EPGVPGYGVK GEKGEPGLVI GPDGSLLHLD GLSGQKGDIG PPGPVGLAGP
YGPSGIKGEF GMPGRPGRPG VNGYKGEKGD TSGGSGYGYP GVPGQPGNPG PPGPPGPTSP
FDRFNRYDDT SRNYPATKGD KGEQGDHGLP GIPGTAPNFD IYAFKNELKG ERGDVGVKGE
KGEQSGGYYD QRFGGVQGQP GPPGKPGLEG PKGDSVMGPP GPQGPPGTPG IGYDGRPGVP
GPPGPPGPPA LPEPYRPNNP VSIPGPPGPP GQPGSPALSS GVTVLRSYET MVATARRQSE
GTLIYILDKA DLYLRVRDGL RQVMLGDYNP FFRDLENEVA EVQPPPVIVY PDTQDQSQNN
GAGHYSHGGP VIRPIEPPPQ PPVNPRYPPQ YDPRFPDPRQ TGHTDGRFVP HQTDNRYSVT
PRRPSPPIPQ PAVPVEPSAS GLHIIALNAP QTGNMRGIRG ADFLCFQQAR AVGLKGTFRA
FLSSKLQDLY TIVRRADRDN FSIVNLKDQV LFDNWESIFG DNTNKMRENV PIYSFDGRDT
LRDSAWPEKM VWHGSNNKGH RQTDHYCETW RTGDHAVSGL ASSLQSRQLL QQSSSSCSGS
YIVLCIENAF TTHSKK
//
