ID A0A6I9U8A4_SESIN Unreviewed; 587 AA.
AC A0A6I9U8A4;
DT 07-OCT-2020, integrated into UniProtKB/TrEMBL.
DT 07-OCT-2020, sequence version 1.
DT 28-JAN-2026, entry version 25.
DE RecName: Full=YTH domain-containing family protein {ECO:0000256|RuleBase:RU369095};
GN Name=LOC105173752 {ECO:0000313|RefSeq:XP_011093936.1};
OS Sesamum indicum (Oriental sesame) (Sesamum orientale).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Lamiales; Pedaliaceae; Sesamum.
OX NCBI_TaxID=4182 {ECO:0000313|Proteomes:UP000504604, ECO:0000313|RefSeq:XP_011093936.1};
RN [1] {ECO:0000313|RefSeq:XP_011093936.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (AUG-2025) to UniProtKB.
CC -!- FUNCTION: Specifically recognizes and binds N6-methyladenosine (m6A)-
CC containing RNAs, and regulates mRNA stability. M6A is a modification
CC present at internal sites of mRNAs and some non-coding RNAs and plays a
CC role in mRNA stability and processing. {ECO:0000256|RuleBase:RU369095}.
CC -!- SIMILARITY: Belongs to the YTHDF family.
CC {ECO:0000256|RuleBase:RU369095}.
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DR RefSeq; XP_011093936.1; XM_011095634.2.
DR AlphaFoldDB; A0A6I9U8A4; -.
DR GeneID; 105173752; -.
DR OrthoDB; 306690at2759; -.
DR Proteomes; UP000504604; Linkage group LG11.
DR GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter.
DR GO; GO:0003729; F:mRNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:1990247; F:N6-methyladenosine-containing RNA reader activity; IEA:UniProtKB-UniRule.
DR GO; GO:0061157; P:mRNA destabilization; IEA:TreeGrafter.
DR CDD; cd21134; YTH; 1.
DR Gene3D; 3.10.590.10; ph1033 like domains; 1.
DR InterPro; IPR007275; YTH_domain.
DR InterPro; IPR045168; YTH_prot.
DR PANTHER; PTHR12357:SF77; YTH DOMAIN-CONTAINING FAMILY PROTEIN; 1.
DR PANTHER; PTHR12357; YTH YT521-B HOMOLOGY DOMAIN-CONTAINING; 1.
DR Pfam; PF04146; YTH; 1.
DR PROSITE; PS50882; YTH; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000504604};
KW RNA-binding {ECO:0000256|RuleBase:RU369095}.
FT DOMAIN 378..515
FT /note="YTH"
FT /evidence="ECO:0000259|PROSITE:PS50882"
FT REGION 1..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 269..349
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..10
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 301..315
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 587 AA; 64035 MW; 64E951E97EF593AE CRC64;
MEDASKQSLD GLTPVPSAGD GAVELHNLTE QQLSPKDERV ASANPSPDAI SEAPRSTKNQ
PAISETSGAL TNMHPFNSYT PPEQAYYFGG YENGSGNWDE HYVNANNLHV IPPMAYGQFS
PLASPLSPIM IDGQLFSPHQ MPVNPPYYPS AVSPGPPHVT SAVPASQTEL VPSGSSSQEN
LIDNAFFGPG SGYYLPFGSF GGGDLSGSSG LGVYKFPGDF GSSDPLPSRS SSLDTSRFMS
PLTSGTVYPQ PIGILGSYEQ NVGQQAQFQG FGLPSNSHAR HLSHGGPYQS AIGPSSNRNR
FYADKGGRRE RDRDTVSIST DALGISGDRN RGPRASKPKS KSLPEESSLA GIKDVESTSG
FHIHNFNSPD FITDYERAKF FVIKSFSEDN IHKSIKYGVW ASTPLGNRKL DAAYRESKEM
EGICPLFLLF SVNASGQFCG VAEMVGPVDF ENDADYWQQD RWSGQFPVKW HIIKDVPNSR
FRHILLENND NKPVTHSRDS QEVKLEQGIE MLRIFKNHDA DTSLLDDFNF YDEREKTLLE
RKAKQRASST GNTAATLATE SINQLSDNLA ETLRLGGGKN LSKMEPE
//
