ID A0A6I9UQ56_SESIN Unreviewed; 1039 AA.
AC A0A6I9UQ56;
DT 07-OCT-2020, integrated into UniProtKB/TrEMBL.
DT 07-OCT-2020, sequence version 1.
DT 18-JUN-2025, entry version 22.
DE RecName: Full=Transcription elongation factor SPT5 {ECO:0000256|PIRNR:PIRNR036945};
GN Name=LOC105179849 {ECO:0000313|RefSeq:XP_011101790.1};
OS Sesamum indicum (Oriental sesame) (Sesamum orientale).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Lamiales; Pedaliaceae; Sesamum.
OX NCBI_TaxID=4182 {ECO:0000313|Proteomes:UP000504604, ECO:0000313|RefSeq:XP_011101790.1};
RN [1] {ECO:0000313|RefSeq:XP_011101790.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=22800194;
RA Zhang H., Wei L., Miao H., Zhang T., Wang C.;
RT "Development and validation of genic-SSR markers in sesame by RNA-seq.";
RL BMC Genomics 13:316-316(2012).
RN [2] {ECO:0000313|RefSeq:XP_011101790.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR036945}.
CC -!- SIMILARITY: Belongs to the SPT5 family. {ECO:0000256|ARBA:ARBA00006956,
CC ECO:0000256|PIRNR:PIRNR036945}.
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DR RefSeq; XP_011101790.1; XM_011103488.2.
DR AlphaFoldDB; A0A6I9UQ56; -.
DR FunCoup; A0A6I9UQ56; 4324.
DR GeneID; 105179849; -.
DR KEGG; sind:105179849; -.
DR InParanoid; A0A6I9UQ56; -.
DR OrthoDB; 28901at2759; -.
DR Proteomes; UP000504604; Linkage group LG2.
DR GO; GO:0032044; C:DSIF complex; IEA:TreeGrafter.
DR GO; GO:0005840; C:ribosome; IEA:InterPro.
DR GO; GO:0003729; F:mRNA binding; IEA:TreeGrafter.
DR GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0032784; P:regulation of DNA-templated transcription elongation; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR GO; GO:0140673; P:transcription elongation-coupled chromatin remodeling; IEA:InterPro.
DR CDD; cd06081; KOW_Spt5_1; 1.
DR CDD; cd06082; KOW_Spt5_2; 1.
DR CDD; cd06083; KOW_Spt5_3; 1.
DR CDD; cd06084; KOW_Spt5_4; 1.
DR CDD; cd06085; KOW_Spt5_5; 1.
DR CDD; cd06086; KOW_Spt5_6; 1.
DR CDD; cd09888; NGN_Euk; 1.
DR FunFam; 2.30.30.30:FF:000027; Transcription elongation factor SPT5; 1.
DR FunFam; 2.30.30.30:FF:000028; Transcription elongation factor SPT5; 1.
DR FunFam; 3.30.70.940:FF:000007; Transcription elongation factor SPT5; 1.
DR Gene3D; 2.30.30.30; -; 4.
DR Gene3D; 3.30.70.940; NusG, N-terminal domain; 1.
DR InterPro; IPR005824; KOW.
DR InterPro; IPR041973; KOW_Spt5_1.
DR InterPro; IPR041975; KOW_Spt5_2.
DR InterPro; IPR041976; KOW_Spt5_3.
DR InterPro; IPR041977; KOW_Spt5_4.
DR InterPro; IPR041978; KOW_Spt5_5.
DR InterPro; IPR041980; KOW_Spt5_6.
DR InterPro; IPR005100; NGN-domain.
DR InterPro; IPR006645; NGN-like_dom.
DR InterPro; IPR036735; NGN_dom_sf.
DR InterPro; IPR039385; NGN_Euk.
DR InterPro; IPR014722; Rib_uL2_dom2.
DR InterPro; IPR005825; Ribosomal_uL24_CS.
DR InterPro; IPR039659; SPT5.
DR InterPro; IPR022581; Spt5_N.
DR InterPro; IPR017071; TF_Spt5_eukaryote.
DR InterPro; IPR008991; Translation_prot_SH3-like_sf.
DR PANTHER; PTHR11125; SUPPRESSOR OF TY 5; 1.
DR PANTHER; PTHR11125:SF7; TRANSCRIPTION ELONGATION FACTOR SPT5; 1.
DR Pfam; PF23042; KOW1_SPT5; 1.
DR Pfam; PF23284; KOW2_Spt5; 1.
DR Pfam; PF23291; KOW4_SPT5; 1.
DR Pfam; PF23290; KOW5_SPT5; 1.
DR Pfam; PF23038; KOW6_SPT51-2; 1.
DR Pfam; PF23287; KOW7_SPT5; 1.
DR Pfam; PF23037; KOWx_SPT5; 1.
DR Pfam; PF03439; Spt5-NGN; 1.
DR Pfam; PF11942; Spt5_N; 1.
DR PIRSF; PIRSF036945; Spt5; 1.
DR SMART; SM00739; KOW; 6.
DR SMART; SM00738; NGN; 1.
DR SUPFAM; SSF50104; Translation proteins SH3-like domain; 1.
DR PROSITE; PS01108; RIBOSOMAL_L24; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Elongation factor {ECO:0000313|RefSeq:XP_011101790.1};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR036945};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Protein biosynthesis {ECO:0000313|RefSeq:XP_011101790.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000504604};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|PIRNR:PIRNR036945};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 174..260
FT /note="NusG-like N-terminal"
FT /evidence="ECO:0000259|SMART:SM00738"
FT DOMAIN 265..292
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 417..444
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 469..496
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 593..620
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 703..730
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 986..1013
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT REGION 1..120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 669..702
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 761..919
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..35
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..68
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 85..108
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 686..699
FT /note="Gly residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 833..843
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 853..865
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 882..895
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1039 AA; 115572 MW; E052F905D8D59444 CRC64;
MPRRRDDYED DDVEQDEEEE YDAVDEEDEE ADDYDDGGKT KRKRTRSDFI DDYAEEDDEE
EEDDDEEYGG GGRGGKRHRK AASEFFDEEA AVDSDEEEEE EEGEDDFIDT GADIPDEDDR
RIHHRPLLPR EDEQEDVEEM ERRIQERYAK SLNVEYDEEA TDVEQQALLP SVRDPKLWMV
KCAIGREREV AVCLMQKFID RGPELQIRSA IALDHLKNYI YIEADKEAHV REAVKGMRNI
YPTKIMLVPI KEMTDVLSVE SKAIDISRDT WVRMKIGTYK GDLAKVVDVD NVRQRATVKL
IPRIDLQALA NKLEGREVQK KKAFTPPARF MNIDEARELH IRVERRRDPA TGDYYEKIEG
MMFKDGFLYK NVSLKSLSTQ NVQPTFDELE KFRQPGETGD GDMSSLSTLF ANRKKGHFMK
GDRVIVVKGD LRNLKGWVEK VEEDTVHIKP NEKGLPKTLA ISDKELCKYF EPGNHVKVVS
GATEGATGMV VSVEGHVVNI VSDTTKELLR VFADNVVESS EVTSGVTRIG DYELHDLVLL
DDNSFGVIIR VESEAFQVLK GVPERPDVAL VRLREIKYKI DKKIFAKDRY KNTLSAKDVV
KILEGPCRGK QGPVEHIYKG ILFIYDRHHL EHAGFICVKS ESCMMVGGSR ANGDRNGNAL
TSRFAHLRTP PRVPQSPMRS ARGGSMNFGG RHGGRSGGGR GHDSLIGASV KIRLGHYKGC
KGRVVDVKGS MVRVELESQM KVVAVDRSYI SDNVNVSTPF RETSRYGMGS ETPMHPSRTP
LHPYMTPMRD SGVTPALDGM RTPMRDRAWN PYTPMSPPRD NWEDGNPGSW GTSPQYQPSS
PRSRAYEAPT PGSGWTSTPS GNYNDAGTPR DSGSAYANAP SPYLPSTPGG QPPMTPSSAY
LPGTPGGQPM TPGSGGLDMM SPVVGSDNEG PWFLPDILVN VRRSGEDSSL GVIREVLPDG
SCKVALGSSG NGEMVTALPS EIEIVAPRKA EKIKIMGGAH RGATGKLIGI DGTDGIVKVD
DTLDVKILDM VILAKLVQT
//
