ID A0A6I9VED0_BACDO Unreviewed; 251 AA.
AC A0A6I9VED0;
DT 07-OCT-2020, integrated into UniProtKB/TrEMBL.
DT 07-OCT-2020, sequence version 1.
DT 28-JAN-2026, entry version 24.
DE RecName: Full=Protein ARV {ECO:0000256|RuleBase:RU368065};
GN Name=LOC105229467 {ECO:0000313|RefSeq:XP_011208084.1};
OS Bactrocera dorsalis (Oriental fruit fly) (Dacus dorsalis).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Tephritoidea;
OC Tephritidae; Bactrocera; Bactrocera.
OX NCBI_TaxID=27457 {ECO:0000313|Proteomes:UP001652620, ECO:0000313|RefSeq:XP_011208084.1};
RN [1] {ECO:0000313|RefSeq:XP_011208084.1}
RP IDENTIFICATION.
RC TISSUE=Adult {ECO:0000313|RefSeq:XP_011208084.1};
RG RefSeq;
RL Submitted (AUG-2025) to UniProtKB.
CC -!- FUNCTION: Mediator of sterol homeostasis involved in sterol uptake,
CC trafficking and distribution into membranes.
CC {ECO:0000256|RuleBase:RU368065}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU368065}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004477,
CC ECO:0000256|RuleBase:RU368065}.
CC -!- SIMILARITY: Belongs to the ARV1 family. {ECO:0000256|ARBA:ARBA00009187,
CC ECO:0000256|RuleBase:RU368065}.
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DR RefSeq; XP_011208084.1; XM_011209782.4.
DR AlphaFoldDB; A0A6I9VED0; -.
DR FunCoup; A0A6I9VED0; 975.
DR GeneID; 105229467; -.
DR KEGG; bdr:105229467; -.
DR CTD; 64801; -.
DR InParanoid; A0A6I9VED0; -.
DR OMA; KLYWKVS; -.
DR OrthoDB; 2192830at2759; -.
DR Proteomes; UP001652620; Chromosome 5.
DR GO; GO:0032541; C:cortical endoplasmic reticulum; IEA:TreeGrafter.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IEA:TreeGrafter.
DR GO; GO:0032366; P:intracellular sterol transport; IEA:UniProtKB-UniRule.
DR GO; GO:0097036; P:regulation of plasma membrane sterol distribution; IEA:UniProtKB-UniRule.
DR GO; GO:0006665; P:sphingolipid metabolic process; IEA:TreeGrafter.
DR GO; GO:0016125; P:sterol metabolic process; IEA:UniProtKB-UniRule.
DR InterPro; IPR007290; Arv1.
DR PANTHER; PTHR14467; ARV1; 1.
DR PANTHER; PTHR14467:SF0; PROTEIN ARV1; 1.
DR Pfam; PF04161; Arv1; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824,
KW ECO:0000256|RuleBase:RU368065};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098,
KW ECO:0000256|RuleBase:RU368065};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055,
KW ECO:0000256|RuleBase:RU368065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU368065};
KW Reference proteome {ECO:0000313|Proteomes:UP001652620};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU368065};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU368065};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU368065}.
FT TRANSMEM 86..103
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368065"
FT TRANSMEM 123..145
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368065"
FT TRANSMEM 165..186
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368065"
FT TRANSMEM 206..234
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368065"
SQ SEQUENCE 251 AA; 29119 MW; 010575FC06926B36 CRC64;
MGKLTSQLKP AYSKQQKQYV CINCGYPIAE LYRKYSNTAI KTNQCENCHK VADKYIEFDP
IIILVDAMLL SQESYRHMLH NCDFKLNWKL SLVLLLLESF ALWRQKGSTK QDAFQNEIIS
EKGFYICCLQ NIIDYCITTL ILFAVTCVHN PRLVESTGYN KFGLILLKAL TIANFSKIFL
LPLIVWRENT TDLGANIHQI LVKGHHLLAL VYIYAIVGNV QKLQSFFIIL PVYLAKEYIK
RHMSVYLELY F
//
