ID A0A6I9W645_9HYME Unreviewed; 848 AA.
AC A0A6I9W645;
DT 07-OCT-2020, integrated into UniProtKB/TrEMBL.
DT 07-OCT-2020, sequence version 1.
DT 18-JUN-2025, entry version 21.
DE SubName: Full=Protein enabled isoform X2 {ECO:0000313|RefSeq:XP_011637048.1};
GN Name=LOC105427129 {ECO:0000313|RefSeq:XP_011637048.1};
OS Pogonomyrmex barbatus (red harvester ant).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Myrmicinae; Pogonomyrmex.
OX NCBI_TaxID=144034 {ECO:0000313|Proteomes:UP000504615, ECO:0000313|RefSeq:XP_011637048.1};
RN [1] {ECO:0000313|RefSeq:XP_011637048.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, lamellipodium
CC {ECO:0000256|ARBA:ARBA00004510}. Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the Ena/VASP family.
CC {ECO:0000256|ARBA:ARBA00009785}.
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DR RefSeq; XP_011637048.1; XM_011638746.2.
DR AlphaFoldDB; A0A6I9W645; -.
DR EnsemblMetazoa; XM_011638746.2; XP_011637048.1; LOC105427129.
DR GeneID; 105427129; -.
DR CTD; 37201; -.
DR OrthoDB; 31170at2759; -.
DR Proteomes; UP000504615; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
DR CDD; cd01207; EVH1_Ena_VASP-like; 1.
DR FunFam; 2.30.29.30:FF:000047; vasodilator-stimulated phosphoprotein isoform X2; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR038023; VASP_sf.
DR InterPro; IPR014885; VASP_tetra.
DR InterPro; IPR000697; WH1/EVH1_dom.
DR PANTHER; PTHR11202:SF22; PROTEIN ENABLED; 1.
DR PANTHER; PTHR11202; SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN FAMILY MEMBER; 1.
DR Pfam; PF08776; VASP_tetra; 1.
DR Pfam; PF00568; WH1; 1.
DR SMART; SM00461; WH1; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF118370; Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain; 1.
DR PROSITE; PS50229; WH1; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000504615};
KW SH3-binding {ECO:0000256|ARBA:ARBA00023036}.
FT DOMAIN 69..182
FT /note="WH1"
FT /evidence="ECO:0000259|PROSITE:PS50229"
FT REGION 22..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 305..446
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 505..542
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 641..796
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..43
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 44..71
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 307..317
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 328..350
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 371..388
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 392..412
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 433..446
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 505..529
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 648..658
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 659..691
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 706..719
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 768..780
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 848 AA; 90477 MW; EB521DE188BB1C7F CRC64;
MWDFPVNSSF KASRTRWSYE WYSSSENQTQ SQDTLSRMRS SVTAQDDAAA QQRATSYRQQ
RSSWQQDSRS PSCEVSISSA RASVMVYDDV NKKWIPSGSS SGLSKVQLYH HQVNNTFRVV
GRKLQDHEIV INCAILKGLK YNQATVTFHQ WRDNKQVYGL NFSSKDDADA FARAMLQALD
VLSNGSNISR SLAPTTTTIT QQQPVYQQQQ QQQQQQQNQA TAQYEEDMGY SQGRNARISL
SLSHLPTGGQ TALPVGSAIT TPEHHTTVSG AVGTVIQMGC ARGSPSDGHS RTMTREDVAI
IQERRMSQQS QATGSPNPIS PSCPPTAQQQ QQQQQQQQQQ QQQQQQQQQQ SGHHRTSSAP
PAPQPPQQQQ TALQTMQGGI ASTITQISAG PGGPPVPPPQ PPIAPPAPPC PPTIMNFNSS
AAPAPPMMMN QYAQSPSSQS NLANQQSQSI YVTNQANQYG AASTSNQYAS AAVANSGGGT
GGSAITVVGQ SPNQFPPSGS QNNFYGTNNQ TSNYTTGGQV NTGQYSQSVG NQATQYGGGG
NQYGSNNSIN QYAAGPLPGP TSQYAVAQSS QSQYGTNIVS QAQAQYGSTG QVQAATTGTT
NPYGTPSTSV NQYVTSGHHT MVSGNTYAPI VSGGPPPPPM VSLVGAAAPP PPPPPPVPNT
NSSATAVSGS SISSSNDPPP DTNSLAAALQ ARLKKKQQQS QPVENSGSST SSSSSNYGTL
GRGGGSGMAS MMDEMAKTLA RRRAAAEKKQ PEQPPEPESS PDKKSWDKNN ASNNKFSNGA
ESPKSVRKRF GSASEDTLLK VNGVNDGTSL TAQEMEAFKV EIIKEVRKEF QKMKQEIIDA
VRTELNKR
//
