ID   A0A6I9X1A3_9HYME        Unreviewed;      1248 AA.
AC   A0A6I9X1A3;
DT   07-OCT-2020, integrated into UniProtKB/TrEMBL.
DT   07-OCT-2020, sequence version 1.
DT   18-JUN-2025, entry version 22.
DE   SubName: Full=Uncharacterized protein LOC105432976 isoform X4 {ECO:0000313|RefSeq:XP_011646321.1};
GN   Name=LOC105432976 {ECO:0000313|RefSeq:XP_011646321.1};
OS   Pogonomyrmex barbatus (red harvester ant).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC   Formicidae; Myrmicinae; Pogonomyrmex.
OX   NCBI_TaxID=144034 {ECO:0000313|Proteomes:UP000504615, ECO:0000313|RefSeq:XP_011646321.1};
RN   [1] {ECO:0000313|RefSeq:XP_011646321.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (MAR-2025) to UniProtKB.
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DR   RefSeq; XP_011646321.1; XM_011648019.1.
DR   RefSeq; XP_011646322.1; XM_011648020.1.
DR   AlphaFoldDB; A0A6I9X1A3; -.
DR   EnsemblMetazoa; XM_011648019.1; XP_011646321.1; LOC105432976.
DR   GeneID; 105432976; -.
DR   CTD; 36914; -.
DR   OrthoDB; 1357022at2759; -.
DR   Proteomes; UP000504615; Unplaced.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-ARBA.
DR   GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.40.370; -; 1.
DR   Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 3.
DR   InterPro; IPR041452; APAF1_C.
DR   InterPro; IPR048975; APAF1_WHD.
DR   InterPro; IPR042197; Apaf_helical.
DR   InterPro; IPR002182; NB-ARC.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR22845; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; 1.
DR   PANTHER; PTHR22845:SF5; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; 1.
DR   Pfam; PF21296; APAF-1-like_WHD; 1.
DR   Pfam; PF17908; APAF1_C; 1.
DR   Pfam; PF00931; NB-ARC; 1.
DR   PRINTS; PR00364; DISEASERSIST.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF50978; WD40 repeat-like; 2.
PE   4: Predicted;
KW   Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW   Reference proteome {ECO:0000313|Proteomes:UP000504615};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   WD repeat {ECO:0000256|ARBA:ARBA00022574}.
FT   DOMAIN          12..233
FT                   /note="NB-ARC"
FT                   /evidence="ECO:0000259|Pfam:PF00931"
FT   DOMAIN          253..320
FT                   /note="Apoptotic protease-activating factor 1 winged-helix"
FT                   /evidence="ECO:0000259|Pfam:PF21296"
FT   DOMAIN          331..468
FT                   /note="APAF-1 helical"
FT                   /evidence="ECO:0000259|Pfam:PF17908"
SQ   SEQUENCE   1248 AA;  145570 MW;  3F72EC06A34E0776 CRC64;
     MNYELKIALQ QLNPTEYIVL HGMKGFGKSC LAASTLKDVK LVKDLFSNQV YWITFACDRL
     IDEEILIQLN TLYHNVRNLE IQPETFTPLA KDSLIQYLKY YFSKQRNCNA LLILDDVYDK
     KIINTFDFKC KTLVLTADID VLYEKRPTII EMNDGFTETE TLGLFAKVLE MDVNELPLEA
     KRIHEECKGM PLLIAMFAAQ FEEFKYDMRV QPDRWRYYLE SLRKKDARNK VMREFLVKQK
     TIFDICIEQL KPDLRKHYES LVIFREDVNI TPKTLEIFWE RNIFEVQELM VDLCHKSLAV
     TKWNKVLKSY IYGVHDLLLC HLRKKHTERE LKLMHELIIR RYCKYCNKDF SKLPNDNYIY
     SYIGYHLEQA ELFKEFPQLY LNFDFIQAKI MHAGLNDLLL DLKMYRKYIT IDYKDEEKIF
     DLERFLQEQA SIIVEHRRKK CLDIIQIAMN YSQQGYVTQT AKNLAMTRRE YLYLSHNKSL
     HNSNMPLTEE ISTGICTSAF TDDPELILTG NTSGEIILWD SSSKKQQKIF NGHREEYSIK
     KIIVSTDGDC FLSLSSAGII MLFPLDEQEE TDQRHSTESP RRKQSCYTPF FINSKGQDDS
     IAKFWVDNEI ILDMAFGDKD QYIVACTNAA TIQVWDRLGK IVFSLKDSKY EYLTKIAFTT
     HLSCFILHIM DESKGAFALY ANSKKDRSTY QYHACYNLQL KSATEKVIFF HHIPKHDDSL
     MVITEKEAMY VRWWWNGDCV SNFSKQTRAF VDDDAVTYVC ATITYDGDYI IMADSAGFIN
     VWNTYSGYQP VATYKSRVIS LDSYWLRDEG YHIICGNGDR ILYRWKFPVE ESDELPRKCL
     FDAIVEPYGK KDIVVKESPS KKIIVSHGEN IINESELIEG KILSLQLSAD GNEAVCITDK
     EIQLLNTKTA ATELISKLDK PIEFVKIVNH YKHNMVVCRW KDNNLKVWQH SRPIFGVDTK
     ANYIHEINNN HVITITQNGI IAIWYIDERW ELRSQVNLSN PLSHILFSSL SYKQNYLAVL
     NESYDLILLH IIHKNAMSST IRIQISNEPY FTYTFAQKAT LCDISKNEQY IAVGLESGQI
     SIIDIRKQME ITRLYFHTNP ITQLHWAPTT IDVPILFSLS CDELVWWNVA LVKNYNRDSQ
     KRRSRMGISH STSTPSLSTN ALLNLQISNS PSVDAGVSNL QNDEASILDR YWRNKIGKDP
     KMPELLHVVE LPPSRDPKIC ISSDFTKYVM VDMYGSINTF KLIDYDQP
//