ID A0A6I9YGN2_9SAUR Unreviewed; 527 AA.
AC A0A6I9YGN2;
DT 07-OCT-2020, integrated into UniProtKB/TrEMBL.
DT 07-OCT-2020, sequence version 1.
DT 28-JAN-2026, entry version 25.
DE SubName: Full=Suppressor of cytokine signaling 5 {ECO:0000313|RefSeq:XP_013923336.1, ECO:0000313|RefSeq:XP_013923337.1};
GN Name=SOCS5 {ECO:0000313|RefSeq:XP_013923336.1,
GN ECO:0000313|RefSeq:XP_013923337.1};
OS Thamnophis sirtalis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Colubridae; Natricinae; Thamnophis.
OX NCBI_TaxID=35019 {ECO:0000313|Proteomes:UP000504617, ECO:0000313|RefSeq:XP_013923336.1};
RN [1] {ECO:0000313|RefSeq:XP_013923336.1, ECO:0000313|RefSeq:XP_013923337.1}
RP IDENTIFICATION.
RC TISSUE=Skeletal muscle {ECO:0000313|RefSeq:XP_013923336.1,
RC ECO:0000313|RefSeq:XP_013923337.1};
RG RefSeq;
RL Submitted (APR-2025) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR RefSeq; XP_013923336.1; XM_014067861.1.
DR RefSeq; XP_013923337.1; XM_014067862.1.
DR AlphaFoldDB; A0A6I9YGN2; -.
DR GeneID; 106550076; -.
DR KEGG; tsr:106550076; -.
DR CTD; 9655; -.
DR OrthoDB; 8820570at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000504617; Unplaced.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR GO; GO:0007259; P:cell surface receptor signaling pathway via JAK-STAT; IEA:InterPro.
DR GO; GO:0007173; P:epidermal growth factor receptor signaling pathway; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd03739; SOCS_SOCS5; 1.
DR FunFam; 1.10.750.20:FF:000002; Suppressor of cytokine signaling 2; 1.
DR FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR037343; SOCS5_SOCS.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF15; SUPPRESSOR OF CYTOKINE SIGNALING 5; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000504617};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 372..452
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 462..511
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 130..155
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 527 AA; 60162 MW; 4727A975247B99E8 CRC64;
MGKVGKMWNS FKYRCQNLFN PEGGNRNENV DINSNSASVR DKSVCVPGAT QQQPNSPLQL
SLNTSKGFSR KNQNCATDIP QIVEISIEKE IDLNVASGAK FARRDSYSRH APWGGKKKHS
CSTKTQSSLE SDTRFGCSHS QRRERRYGVS SVNDTDSISS RTIGNRSLRQ RLQETVGLCF
PMRTYCKQSK PLFSNKRKIH LSELMLEKCP FPAGSDLAQK WHLIKQHTAP VSPHSAIFDA
FDSSLASTED EEDRLRERRR LSIEEGVDPP PNAQIHTFEA TAQVNPLYKL GPKLPPGMSE
LMGDCNSTTQ GSCDLEEDTT TLCLQSRRQK QRQISGESHS HISRQGAWKV HTQIDYIHCL
VPDLLQITSN PCYWGVMDRY EAEALLEGKP EGTFLLRDSA QEDYLFSVSF RRYNRSLHAR
IEQWNHNFSF DAHDPCVFHS STVTGLLEHY KDPISCMFFE PLLTVSLNRT FPFSLQYICR
AVICRCTSYD GIDCLPLPTM LQDFLKEYHY KQKVRVRWLE REPIKAK
//
