ID A0A6I9YZE4_9SAUR Unreviewed; 714 AA.
AC A0A6I9YZE4;
DT 07-OCT-2020, integrated into UniProtKB/TrEMBL.
DT 07-OCT-2020, sequence version 1.
DT 28-JAN-2026, entry version 25.
DE SubName: Full=Collagen alpha-1(XVIII) chain-like {ECO:0000313|RefSeq:XP_013929414.1};
GN Name=LOC106555157 {ECO:0000313|RefSeq:XP_013929414.1};
OS Thamnophis sirtalis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Colubridae; Natricinae; Thamnophis.
OX NCBI_TaxID=35019 {ECO:0000313|Proteomes:UP000504617, ECO:0000313|RefSeq:XP_013929414.1};
RN [1] {ECO:0000313|RefSeq:XP_013929414.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (AUG-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR RefSeq; XP_013929414.1; XM_014073939.1.
DR AlphaFoldDB; A0A6I9YZE4; -.
DR GeneID; 106555157; -.
DR KEGG; tsr:106555157; -.
DR OrthoDB; 10060752at2759; -.
DR Proteomes; UP000504617; Unplaced.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR GO; GO:0031012; C:extracellular matrix; IEA:TreeGrafter.
DR GO; GO:0005615; C:extracellular space; IEA:TreeGrafter.
DR GO; GO:0030020; F:extracellular matrix structural constituent conferring tensile strength; IEA:TreeGrafter.
DR GO; GO:0030198; P:extracellular matrix organization; IEA:TreeGrafter.
DR Gene3D; 3.40.1620.70; -; 1.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR050149; Collagen_superfamily.
DR InterPro; IPR010515; Collagenase_NC10/endostatin.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR045463; XV/XVIII_trimerization_dom.
DR PANTHER; PTHR24023:SF1112; COL_CUTICLE_N DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR PANTHER; PTHR24023; COLLAGEN ALPHA; 1.
DR Pfam; PF01391; Collagen; 2.
DR Pfam; PF20010; Collagen_trimer; 1.
DR Pfam; PF06482; Endostatin; 1.
DR SUPFAM; SSF56436; C-type lectin-like; 1.
PE 4: Predicted;
KW Collagen {ECO:0000256|ARBA:ARBA00023119};
KW Reference proteome {ECO:0000313|Proteomes:UP000504617};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 458..501
FT /note="Collagen type XV/XVIII trimerization"
FT /evidence="ECO:0000259|Pfam:PF20010"
FT DOMAIN 542..711
FT /note="Collagenase NC10/endostatin"
FT /evidence="ECO:0000259|Pfam:PF06482"
FT REGION 66..364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 385..406
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 109..120
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 127..140
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 145..175
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 176..187
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 245..254
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 256..266
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 321..334
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 391..406
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 714 AA; 74760 MW; 3AE80E82154D48A9 CRC64;
MEEDSEFIIV QGGSKILTTS DYQSMITGDT KMTQTTSEVL MTSVQKSNIT GDSMARPSNY
TSQCVCPAIP GPPGPKGEKG DQGPPGQTGK IGPTGKPGYP GVAGLQGVPG PPGPPGPPGS
TLPKPLDVTD TKDGEDKRVC YVEGPPGPPG IPGHPGHPGP QGYPGPEGPQ GPPGLPGHEG
QQGAPGLPGA PGQPGAPGAT GPSGIPGPVG PEGPPGVTGP EGHAGIPGQI GSPGLPGFPG
PEGPPGASGS PGKNGSKGEK GEKGDCGELG LPGKPGQTGE KGDRGELGLP GKPGQTGEKG
AQGPPGLAGP PGLPGGNQTR AELKSSVKQL EKYNSEVSVQ GPPGPKGEKG EPGKVDSSSC
SKDARSDIDS WIALIYQKKF KEDLEARGPN HGPPGLPGPP GPPGPPGVLY INRVYPVRPR
PHCKQPVNQD PCFDSDMEQP MKDSPDKSQN GYKHPTWTFS SKELMLKSAS SIPQGSLVYI
TEDDEAFFKT PKGWKKIVME DSAFQFAADD PLVPMVNKQL DERTITIPTM APTSIPQRIP
SLRLIALNFP LTGNMRGISG ADLHCYQQAQ EANLQGTFRA FLSGDSQSLI SVVKRTDRNL
PLVNLKGQLL AKSWNSLFTK HGISDFNTKE HPIYAFNGLN VMTNSTWIYK AVWHGLTLQI
NHSKTQDCEN WRKASKYLRG QASVPLKDVF LQETSWRCTD LLIVLCVENS FGST
//
