ID A0A6J0Y5D4_ODOVR Unreviewed; 410 AA.
AC A0A6J0Y5D4;
DT 07-OCT-2020, integrated into UniProtKB/TrEMBL.
DT 07-OCT-2020, sequence version 1.
DT 28-JAN-2026, entry version 23.
DE RecName: Full=Proteasomal ubiquitin receptor ADRM1 {ECO:0000256|ARBA:ARBA00068549};
DE AltName: Full=Rpn13 homolog {ECO:0000256|ARBA:ARBA00079688};
GN Name=ADRM1 {ECO:0000313|RefSeq:XP_020756770.1};
OS Odocoileus virginianus (White-tailed deer).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Cervidae;
OC Odocoileinae; Odocoileus.
OX NCBI_TaxID=9874 {ECO:0000313|Proteomes:UP001652640, ECO:0000313|RefSeq:XP_020756770.1};
RN [1] {ECO:0000313|Proteomes:UP001652640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=35511871;
RA London E.W., Roca A.L., Novakofski J.E., Mateus-Pinilla N.E.;
RT "A De Novo Chromosome-Level Genome Assembly of the White-Tailed Deer,
RT Odocoileus Virginianus.";
RL J. Hered. 113:479-489(2022).
RN [2] {ECO:0000313|RefSeq:XP_020756770.1}
RP IDENTIFICATION.
RC TISSUE=Tongue muscle {ECO:0000313|RefSeq:XP_020756770.1};
RG RefSeq;
RL Submitted (AUG-2025) to UniProtKB.
CC -!- SUBUNIT: Component of the 19S proteasome regulatory particle complex.
CC The 26S proteasome consists of a 20S core particle (CP) and two 19S
CC regulatory subunits (RP). Interacts with the proteasomal scaffolding
CC protein PSMD1. Interacts with deubiquitinase UCHL5; this interaction
CC activates the auto-inhibited UCHL5 by deoligomerizing it. Interacts
CC with UBQLN2 and ubiquitin. {ECO:0000256|ARBA:ARBA00061738}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the ADRM1 family.
CC {ECO:0000256|ARBA:ARBA00009216}.
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DR RefSeq; XP_020756770.1; XM_020901111.2.
DR AlphaFoldDB; A0A6J0Y5D4; -.
DR FunCoup; A0A6J0Y5D4; 2693.
DR GeneID; 110142088; -.
DR KEGG; ovr:110142088; -.
DR InParanoid; A0A6J0Y5D4; -.
DR OrthoDB; 340431at2759; -.
DR Proteomes; UP001652640; Chromosome 9.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0008541; C:proteasome regulatory particle, lid subcomplex; IEA:TreeGrafter.
DR GO; GO:0061133; F:endopeptidase activator activity; IEA:TreeGrafter.
DR GO; GO:0070628; F:proteasome binding; IEA:TreeGrafter.
DR CDD; cd13314; PH_Rpn13; 1.
DR FunFam; 1.10.2020.20:FF:000001; Proteasomal ubiquitin receptor ADRM1; 1.
DR FunFam; 2.30.29.70:FF:000001; Proteasomal ubiquitin receptor ADRM1; 1.
DR Gene3D; 1.10.2020.20; -; 1.
DR Gene3D; 2.30.29.70; Proteasomal ubiquitin receptor Rpn13/ADRM1; 1.
DR InterPro; IPR044867; DEUBAD_dom.
DR InterPro; IPR006773; Rpn13/ADRM1.
DR InterPro; IPR044868; Rpn13/ADRM1_Pru.
DR InterPro; IPR038633; Rpn13/ADRM1_Pru_sf.
DR InterPro; IPR032368; RPN13_DEUBAD.
DR InterPro; IPR038108; RPN13_DEUBAD_sf.
DR PANTHER; PTHR12225; ADHESION REGULATING MOLECULE 1 110 KDA CELL MEMBRANE GLYCOPROTEIN; 1.
DR PANTHER; PTHR12225:SF0; PROTEASOMAL UBIQUITIN RECEPTOR ADRM1; 1.
DR Pfam; PF04683; Rpn13_ADRM1_Pru; 1.
DR Pfam; PF16550; RPN13_C; 1.
DR PROSITE; PS51916; DEUBAD; 1.
DR PROSITE; PS51917; PRU; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Proteasome {ECO:0000256|ARBA:ARBA00022942};
KW Receptor {ECO:0000313|RefSeq:XP_020756770.1};
KW Reference proteome {ECO:0000313|Proteomes:UP001652640}.
FT DOMAIN 21..134
FT /note="Pru"
FT /evidence="ECO:0000259|PROSITE:PS51917"
FT DOMAIN 280..394
FT /note="DEUBAD"
FT /evidence="ECO:0000259|PROSITE:PS51916"
FT REGION 199..262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 381..410
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 410 AA; 42409 MW; B988E9919D6B25E5 CRC64;
MHRMTTSGAL FPSLVPGSRG SSNKYLVEFR AGKMSLKGTT VTPDKRKGLV YIQQTDDSLI
HFCWKDRTSG NVEDDLIIFP DDCEFKRVPQ CPSGRVYVLK FKAGSKRLFF WMQEPKTDQD
EEHCRKVNEY LNNPPMPGAL GASGSGGHEL SALGGEGGLQ SLLGNMSHSQ LMQLIGPAGL
GGLGGLGALT GPGLASLLGS GGPPASSSSS SSRSQSAAVT PSSTTSSTRA TPAPSAPAAA
SATSPSPAPS SGDGASTAAS PAQPIQLSDL QSILATMSVP AGPGSGQQVD LASVLTPEIM
APILANADVQ ERLLPYLPSG ESLPQTAEEI QNTLTSPQFQ QALGMFSAAL ASGQLGPLMC
QFGLPAEAVE AANKGDVEAF AKAMQNSASP EQQEGDGKDK KDEEEDMSLD
//
