ID A0A6J1BXP8_MOMCH Unreviewed; 476 AA.
AC A0A6J1BXP8;
DT 07-OCT-2020, integrated into UniProtKB/TrEMBL.
DT 07-OCT-2020, sequence version 1.
DT 28-JAN-2026, entry version 25.
DE SubName: Full=Protein FIZZY-RELATED 3 {ECO:0000313|RefSeq:XP_022134054.1};
GN Name=LOC111006420 {ECO:0000313|RefSeq:XP_022134054.1};
OS Momordica charantia (Bitter gourd) (Balsam pear).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Cucurbitales; Cucurbitaceae; Momordiceae; Momordica.
OX NCBI_TaxID=3673 {ECO:0000313|Proteomes:UP000504603, ECO:0000313|RefSeq:XP_022134054.1};
RN [1] {ECO:0000313|RefSeq:XP_022134054.1}
RP IDENTIFICATION.
RC STRAIN=OHB3-1 {ECO:0000313|RefSeq:XP_022134054.1};
RG RefSeq;
RL Submitted (AUG-2025) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SIMILARITY: Belongs to the WD repeat CDC20/Fizzy family.
CC {ECO:0000256|ARBA:ARBA00006445}.
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DR RefSeq; XP_022134054.1; XM_022278362.1.
DR AlphaFoldDB; A0A6J1BXP8; -.
DR GeneID; 111006420; -.
DR KEGG; mcha:111006420; -.
DR OrthoDB; 10263272at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000504603; Unplaced.
DR GO; GO:0005680; C:anaphase-promoting complex; IEA:TreeGrafter.
DR GO; GO:0010997; F:anaphase-promoting complex binding; IEA:InterPro.
DR GO; GO:1990757; F:ubiquitin ligase activator activity; IEA:TreeGrafter.
DR GO; GO:0031145; P:anaphase-promoting complex-dependent catabolic process; IEA:TreeGrafter.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:1905786; P:positive regulation of anaphase-promoting complex-dependent catabolic process; IEA:TreeGrafter.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd00200; WD40; 1.
DR FunFam; 2.130.10.10:FF:000025; FIZZY-related 2 isoform 1; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR033010; Cdc20/Fizzy.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR056150; WD40_CDC20-Fz.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19918; CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED; 1.
DR PANTHER; PTHR19918:SF36; PROTEIN FIZZY-RELATED 3; 1.
DR Pfam; PF24807; WD40_CDC20-Fz; 1.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Reference proteome {ECO:0000313|Proteomes:UP000504603};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 161..450
FT /note="CDC20/Fizzy WD40"
FT /evidence="ECO:0000259|Pfam:PF24807"
FT REPEAT 289..330
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 331..375
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 419..460
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 96..159
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 99..111
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 122..134
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 149..158
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 476 AA; 52001 MW; 8A721A975C7059E9 CRC64;
MDSPQTKSGL NLPAGMTQRS LRLETFSGSF RAISSLSSPS KTSTCSDRFI PCRSSSRLHT
FGLNEKASPV KEGANEAYSR LLKSELFGSD FASFSPAAGS QGQGSPMSSP SKNMLRFKTD
HSAPNSPYSP SIFSQDPAFP SEISTPPKPP RKVPKTPHKV LDAPSLQDDF YLNLVDWSSQ
NVLAVGLGTC VYLWSASNCK VTKLCDLGPN DGVCSVQWTR EGSYISIGTN LGQVQIWDGS
QCKKVRTMGG HQTRTGVLAW NSRILASGSR DRNILQHDLR VSSEFVNKLV GHKSEVCGLK
WSNDDRELAS GGNDNQLLVW NQHSQQPVLR LTEHTAAVKA IAWSPHQSGL LASGGGTADR
CIRFWNTANG HQLESVDTGS QVCNLAWSKN VNELVSTHGY SQNQIMVWKY PSMGKVATLT
GHTMRVLYLA MSPDGQTIVT GAGDETLRFW NIFPSMKTQT PVRDTGLWSL GRTQIR
//
