ID   A0A6J1J0S7_CUCMA        Unreviewed;       435 AA.
AC   A0A6J1J0S7;
DT   07-OCT-2020, integrated into UniProtKB/TrEMBL.
DT   07-OCT-2020, sequence version 1.
DT   28-JAN-2026, entry version 25.
DE   RecName: Full=Growth-regulating factor {ECO:0000256|RuleBase:RU367127};
GN   Name=LOC111481644 {ECO:0000313|RefSeq:XP_022982951.1};
OS   Cucurbita maxima (Pumpkin) (Winter squash).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Cucurbitales; Cucurbitaceae; Cucurbiteae; Cucurbita.
OX   NCBI_TaxID=3661 {ECO:0000313|Proteomes:UP000504608, ECO:0000313|RefSeq:XP_022982951.1};
RN   [1] {ECO:0000313|RefSeq:XP_022982951.1}
RP   IDENTIFICATION.
RC   TISSUE=Young leaves {ECO:0000313|RefSeq:XP_022982951.1};
RG   RefSeq;
RL   Submitted (AUG-2025) to UniProtKB.
CC   -!- FUNCTION: Transcription activator. {ECO:0000256|RuleBase:RU367127}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|PROSITE-ProRule:PRU01002, ECO:0000256|RuleBase:RU367127}.
CC   -!- DOMAIN: The QLQ domain and WRC domain may be involved in protein-
CC       protein interaction and DNA-binding, respectively.
CC       {ECO:0000256|RuleBase:RU367127}.
CC   -!- SIMILARITY: Belongs to the GRF family. {ECO:0000256|ARBA:ARBA00008122,
CC       ECO:0000256|RuleBase:RU367127}.
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DR   RefSeq; XP_022982951.1; XM_023127183.1.
DR   AlphaFoldDB; A0A6J1J0S7; -.
DR   GeneID; 111481644; -.
DR   KEGG; cmax:111481644; -.
DR   OrthoDB; 1927209at2759; -.
DR   Proteomes; UP000504608; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006351; P:DNA-templated transcription; IEA:UniProtKB-UniRule.
DR   GO; GO:0099402; P:plant organ development; IEA:UniProtKB-ARBA.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   InterPro; IPR014978; Gln-Leu-Gln_QLQ.
DR   InterPro; IPR031137; GRF.
DR   InterPro; IPR014977; WRC_dom.
DR   PANTHER; PTHR31602:SF63; GROWTH-REGULATING FACTOR 3; 1.
DR   PANTHER; PTHR31602; GROWTH-REGULATING FACTOR 5; 1.
DR   Pfam; PF08880; QLQ; 1.
DR   Pfam; PF08879; WRC; 1.
DR   SMART; SM00951; QLQ; 1.
DR   PROSITE; PS51666; QLQ; 1.
DR   PROSITE; PS51667; WRC; 1.
PE   3: Inferred from homology;
KW   Activator {ECO:0000256|RuleBase:RU367127};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW   ProRule:PRU01002}; Reference proteome {ECO:0000313|Proteomes:UP000504608};
KW   Transcription {ECO:0000256|RuleBase:RU367127};
KW   Transcription regulation {ECO:0000256|RuleBase:RU367127}.
FT   DOMAIN          92..127
FT                   /note="QLQ"
FT                   /evidence="ECO:0000259|PROSITE:PS51666"
FT   DOMAIN          164..208
FT                   /note="WRC"
FT                   /evidence="ECO:0000259|PROSITE:PS51667"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          315..378
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           169..179
FT                   /note="Bipartite nuclear localization signal"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01002"
FT   MOTIF           197..204
FT                   /note="Bipartite nuclear localization signal"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01002"
FT   COMPBIAS        1..14
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        323..341
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        347..357
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   435 AA;  47230 MW;  03816FA3B3D97CC6 CRC64;
     MDFDLKKCRR QAESEKEEEV EEPQHSAKIC KFFVEQPHRL QQQQPQPSSC SSVLPLFVPG
     SINDSKASNM LSAFPDSTSS SSSHRLPRTL GYFSVAQRHE LELQALIFRY MLAGVAVPPE
     LLHPIKKSLL SSTAPLFLHH PLQHFPHYPT SLLQAGYWGR AAMDPEPGRC RRTDGKKWRC
     SRDVVAGQKY CERHMHRGRN RSRKPVETTT TKPTYTTTTT TTAAAVSSGG GSLCSNANRV
     VGGGGGRPFS TVESGKYSCV CGQTPSVDLL HLNQGASSDS LPENKNFYES QKEASAGDGK
     SDGHILRHFF DDWPRSENGD CGSDNSNASQ RMNPTSLSIS VAGNPPSSSS DVSLKLSTGG
     GSDQGSGDPH LHQNGNIDGE HMHLNWAAGW AATQMASMGG PLAEALRSAN KNSLPTTVLH
     QLQRTTNSEA NFIST
//