ID   A0A6J1KC40_CUCMA        Unreviewed;       827 AA.
AC   A0A6J1KC40;
DT   07-OCT-2020, integrated into UniProtKB/TrEMBL.
DT   07-OCT-2020, sequence version 1.
DT   10-JUN-2026, entry version 28.
DE   SubName: Full=DExH-box ATP-dependent RNA helicase DExH9-like isoform X4 {ECO:0000313|RefSeq:XP_022999927.1};
GN   Name=LOC111494259 {ECO:0000313|RefSeq:XP_022999927.1};
OS   Cucurbita maxima (Pumpkin) (Winter squash).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Cucurbitales; Cucurbitaceae; Cucurbiteae; Cucurbita.
OX   NCBI_TaxID=3661 {ECO:0000313|Proteomes:UP000504608, ECO:0000313|RefSeq:XP_022999927.1};
RN   [1] {ECO:0000313|RefSeq:XP_022999927.1}
RP   IDENTIFICATION.
RC   TISSUE=Young leaves {ECO:0000313|RefSeq:XP_022999927.1};
RG   RefSeq;
RL   Submitted (JAN-2026) to UniProtKB.
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DR   RefSeq; XP_022999927.1; XM_023144159.1.
DR   AlphaFoldDB; A0A6J1KC40; -.
DR   GeneID; 111494259; -.
DR   Proteomes; UP000504608; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:TreeGrafter.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR   GO; GO:0000460; P:maturation of 5.8S rRNA; IEA:TreeGrafter.
DR   GO; GO:0006401; P:RNA catabolic process; IEA:InterPro.
DR   CDD; cd18795; SF2_C_Ski2; 1.
DR   FunFam; 3.40.50.300:FF:000141; ATP-dependent RNA helicase DOB1; 1.
DR   FunFam; 2.40.30.300:FF:000003; DEAD-box family ATP dependent helicase; 1.
DR   FunFam; 1.20.1500.20:FF:000002; DEAD/DEAH box helicase, putative; 1.
DR   FunFam; 1.10.3380.30:FF:000009; DExH-box ATP-dependent RNA helicase DExH9; 1.
DR   Gene3D; 1.10.3380.30; -; 1.
DR   Gene3D; 2.40.30.300; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR025696; Beta-barrel_MTR4.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C-like.
DR   InterPro; IPR048392; MTR4-like_stalk.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR050699; RNA-DNA_Helicase.
DR   InterPro; IPR016438; SKI2-like.
DR   InterPro; IPR012961; Ski2/MTR4_C.
DR   PANTHER; PTHR12131; ATP-DEPENDENT RNA AND DNA HELICASE; 1.
DR   PANTHER; PTHR12131:SF25; DEXH-BOX ATP-DEPENDENT RNA HELICASE DEXH9; 1.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF08148; DSHCT; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF21408; MTR4-like_stalk; 1.
DR   Pfam; PF13234; MTR4_beta-barrel; 1.
DR   PIRSF; PIRSF005198; Antiviral_helicase_SKI2; 1.
DR   SMART; SM01142; DSHCT; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000504608}.
FT   DOMAIN          1..70
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          145..347
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
FT   COILED          363..390
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   827 AA;  94468 MW;  85C79DCA11844F27 CRC64;
     MQYKGSEVTR EVAWIIFDEV HYMRDRERGV VWEESIVMAP KNARFVFLSA TVPNAKEFAD
     WVAKVHQQPC HIVYTDFRPT PLQHYVFPSG GEGLYLVVDE KGHFREDSFQ KALNALVPAS
     DGDKKKENGK WQKSLTLGKT GEESDIFKMV KMIIQRQYDP VILFSFSKRE CEFLAMQMAR
     LDLNGDDEKA SIETIFWSAM DMLSDDDKKL PQVSNMLPLL KRGIGVHHSG LLPILKEVIE
     ILFQEGLIKC LFATETFSIG LNMPAKTVVF SNVRKFDGDK FRWLSSGEYI QMSGRAGRRG
     IDKRGICILM VDEKLEPSTA KMMLKGNADC LNSAFHLSYN MLLNQIRCED GDPENLLRNS
     FYQFQADRNI PNLEKQVKTL EEERDSIVIE EEDSLKNYYD LLKQYKSLKK DIHDIVLSPR
     YCLPFLQPGR LVSIECNRYD VNSSTFSIKD QVTWGLMINF QRVKGVSEED ISMKPESANY
     TVDVLTRCVV SKDAIGKKTV KIVQLKEHGE PHVVSIPISQ ISTLAGIRIL IPNDLLPLET
     RENTLKKISE VLSRFPKGVP LLDPEEDMKI QSSSYRKAVR RTEALENLFD KHEVAKSTLV
     EQKLKALHLK QELTAKIRSI KKTMRSSSAL AFKDELKARK RVLRRLGCIT SDDVVELKGK
     VACEISSANE LTLSELMLNG VFNDTKVEEL ISLLSCFVWQ EKLQDAAKPR EELELLFIQL
     QDTARRVAKV QLECKVEIDV EGFVNSFRAD IMEVVYGWAK GSKFYEIMEI TQVFEGSLVR
     AIRRLEEVLQ QLIVAAKAIG ETELETKFEE AVSKIKRDIV FAASLYL
//