ID A0A6J1R2A5_9HYME Unreviewed; 4744 AA.
AC A0A6J1R2A5;
DT 07-OCT-2020, integrated into UniProtKB/TrEMBL.
DT 07-OCT-2020, sequence version 1.
DT 18-JUN-2025, entry version 22.
DE RecName: Full=Dynein-1, subspecies f {ECO:0000256|ARBA:ARBA00077719};
GN Name=LOC112464273 {ECO:0000313|RefSeq:XP_024886930.1};
OS Temnothorax curvispinosus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Myrmicinae; Temnothorax.
OX NCBI_TaxID=300111 {ECO:0000313|Proteomes:UP000504618, ECO:0000313|RefSeq:XP_024886930.1};
RN [1] {ECO:0000313|RefSeq:XP_024886930.1}
RP IDENTIFICATION.
RC TISSUE=Whole body {ECO:0000313|RefSeq:XP_024886930.1};
RG RefSeq;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- FUNCTION: Force generating protein of eukaryotic cilia and flagella.
CC Produces force towards the minus ends of microtubules. Dynein has
CC ATPase activity; the force-producing power stroke is thought to occur
CC on release of ADP. Required for assembly of the I1 inner arm complex
CC and its targeting to the appropriate axoneme location. Also required
CC for phototaxis. {ECO:0000256|ARBA:ARBA00054075}.
CC -!- SUBUNIT: The I1 inner arm complex (also known as the f dynein complex)
CC is a two-headed isoform composed of two heavy chains (1-alpha and 1-
CC beta), three intermediate chains and three light chains. I1 occupies a
CC specific position proximal to the first radial spoke and repeats every
CC 96 nm along the length of the axoneme. {ECO:0000256|ARBA:ARBA00063032}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum
CC {ECO:0000256|ARBA:ARBA00004230}. Cytoplasm, cytoskeleton, cilium
CC axoneme {ECO:0000256|ARBA:ARBA00004430}.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR RefSeq; XP_024886930.1; XM_025031162.1.
DR GeneID; 112464273; -.
DR OrthoDB; 64868at2759; -.
DR Proteomes; UP000504618; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; IEA:UniProtKB-ARBA.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd00009; AAA; 1.
DR FunFam; 3.40.50.300:FF:000153; Dynein axonemal heavy chain 1; 1.
DR FunFam; 1.10.8.720:FF:000005; Dynein axonemal heavy chain 10; 1.
DR FunFam; 1.20.1270.280:FF:000005; Dynein axonemal heavy chain 10; 1.
DR FunFam; 1.20.920.30:FF:000007; Dynein axonemal heavy chain 10; 1.
DR FunFam; 3.10.490.20:FF:000006; Dynein axonemal heavy chain 10; 1.
DR FunFam; 3.40.50.300:FF:000884; Dynein axonemal heavy chain 10; 1.
DR FunFam; 1.10.8.1220:FF:000001; Dynein axonemal heavy chain 5; 1.
DR FunFam; 3.40.50.300:FF:002141; Dynein heavy chain; 1.
DR FunFam; 1.20.58.1120:FF:000008; Dynein heavy chain 10, axonemal; 1.
DR FunFam; 1.10.8.710:FF:000002; dynein heavy chain 17, axonemal; 1.
DR FunFam; 1.20.140.100:FF:000001; dynein heavy chain 17, axonemal; 1.
DR FunFam; 1.10.287.2620:FF:000002; Dynein heavy chain 2, axonemal; 1.
DR FunFam; 1.20.920.20:FF:000001; dynein heavy chain 2, axonemal; 1.
DR FunFam; 3.40.50.300:FF:000044; Dynein heavy chain 5, axonemal; 1.
DR FunFam; 3.40.50.300:FF:000049; Dynein, axonemal, heavy chain 5; 1.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR22878:SF63; DYNEIN AXONEMAL HEAVY CHAIN 10; 1.
DR PANTHER; PTHR22878; DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 2.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Flagellum {ECO:0000256|ARBA:ARBA00022846};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000504618};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 2074..2212
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2355..2641
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2719..2872
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 160..181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 204..267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1014..1041
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3375..3406
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3533..3626
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 14..27
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 161..181
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 246..258
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4744 AA; 546940 MW; 242B61739D0EDCAA CRC64;
MSTSTLHTSS VQDSSEEEEE EEEDDGEQTG SGDFLSYPKK KADLKSASID SSAVSAPPLG
EEDKYVLTKK MVEKVRQVPV LHMICGQVDG NRADLQDVTF FYFMRTSDEG IPSFDTYEEC
LNEITSYLVV GSLDRKFLSS LNSILVNVFK PLVENQFRTP DTGERWQTKS ADNGKRKNVD
VEARSMLRRP SHFVTASSLV SRQNLDAKRK GDDEGNATIS VATLQDEIPR NRKQKSSLKG
FDKRSVPSVS ESKSSKSISS KEIKKQPAGE QIKKDILDYL DNLIEKTEWT LEHVESDILL
TMPKIPELND PAITDDMLLK NKDIVEQMEE VVMLWEKHIQ KVMESYESKV LPKKGPIAEH
QYWQDCETGL TILVEQLKMP IVKRILTLLD QALSPIASSF HYYQTELWKH YVEARDNNKF
VQTLLRYFKL MTESDSFESI SDCIPSLMEG LRMLWVLSSY YCHEEKIMLL MDRISWQLCE
NVKQNLAIVL LFKKPLEEIL EKTSMASAML RQWKRSYLKT RLDIELSGKG ARWEFDQKRL
FQNTEYIAEV CSDLYKIADV LQDFYNIFGP DLKSIINDPA QIDAVIKRVD ALVVPIEEAD
FDIFNVFNKE NWEALTAWFY EQVTFLEDQA KFYIDECFMV LISAENSLEM LLKFKNMKTR
AAIQRQLLRK FDVIMQQFSK EVNIVESIFH RGKWHPPLLT YHPPMAGAIF WVKQLFHGLR
RPVLIFQEVR ELKHSELKLL AFSQYLDLAK QLKNFEEAKF NMWLDKALLT VTAIMKKSVL
RIVRVERDSP VALTFPDEER VTKNLQLIHV ASKAKGKDVG SFLSTPRESL LKLDGVMSKP
SAEIESSIAA GSRIISMTQP RAEVKADARG SSLKDCKTST VSFDKHDARA KIAWPEFMSG
AILVECQLRF QVNFDWEVFE VIREAELMEH LGFELPATIR NVGIQKNRLR TDIDATTKMI
SQYNNTLDTL DRADIQLLKQ TLQDVEKHIQ PGVTRFNWNS LSISDYASTC SRILKNLNSI
VEQVNQIKKE LDNRIESELQ SYHLFSTKKE VADSEVLLPC KCYFTEIKNR RSELVSSMLK
TYQSISPMLV KLESLVLGTS TGTSPAMQLL YEKYEKKIFA AFIICMVRNM EVLNKILNNT
KPIFQVDALL ITSEVILRPS PNEIYNTICY DVRNLLERLK EFSRWMNGTC LECKPQRREL
SEDLVVFSFF EDVMSVRIIN ELVRVVHDTA YRISMECSRY LYRWKKYSNL WSFDKNLACE
KFASTKPTLL QYDEKFTFYE GILEELEDMS SYFDINSVRL NLKPLLSGIE RQAKEWKQVL
GNYLLSDTVL AMSELKTQID TFRGEIELVI TGLDRFVSIM QAIADVRNMA IQAEVQFLCY
QECFQTMRAH GIVFPLSDEA MAYELQHDWE SLYLGALYRA STLESTSEKF AELTREQIQQ
FLVETEMFAE DFEAHGPGSI GNDLELGLKK MDEYGKLIHN YEERRLSLIK LENLFDLLST
DYSTLLKIKT EYEGMDVLYN LYKEQRSARE IWAKTLWVNL NPQQLIEGME HFIREFRRLP
KSIRATNVGH ALETNIKNFK NSVPLFIELK NEAMRERHWQ ELMRRTGQYF DMDPDRFTLE
NMFAMELGKY QDIAQDIVMY AVKELAIERG VKELAEVWKS MEFNIVKHYK GTEDRGFILG
PLDELNLVLE DNMLTVHSMA ASQFIGPFLN VVQKWERTMH TISEVLEVWV DLQRKWLYLE
GIFVGGDIRF QLPDETKRFD DIDQAFRKIM TDTSKRLNVL ECCTIYGRKD EFEAMIAALE
KCQKSLTEYL RNKRIIFPRF NFISDDELLS ILGSGNPMAI QEHVGKMFDN LDKFALVSDN
MDRLMATALI SCEREVMDFR NPVSTEDQIE IWMGLALEEM KRSNRYLTKK AIYDYGKVRR
PRTQWILEFQ GMMILVANQI WWTAEVENVF EKISQGNTRA MKEYLQQLNT QLDEVVTLMG
TGTLTNNDRK KIDMVLTIDV HIRDIIEGFV RDSIVDPTEF KWESQLRFYW VHDLDNVWMN
QCTGTFEYGY EYMGLNGRLV ITPLTDRIYL TITQALSMHL GGPAGTGKTE TVKDLAKALG
LLCIVTNCGE GMDYITIGKT LGGLAQCGAW GCFDEFNRID SSVLSVISTQ LQTIRSALQV
KAQRFTFENQ DIVLDTKVGI FITMNPGYAG RTELPESVKA LFRPVVCIVP DNELICQIKL
FSAGFLTAKL LAKKMTVLYK LASEQLSKQT HYDFGLRALK SVLNMAGQLK RTSNDLPENV
VLMRALRDMN LPKFIYDDVP LFLGLIRDLF PDLDCPRVRY PDFNEAVEAV LEKHGYIVLP
EQVDKVIQLY EVMMTRHSTM VIGPTGGGKT VVIETLCRAQ THLGKLTKLH ILNPKACTVI
ELYGTLDPTT RDWTDGLLSS IFREINRPLD PGKDERRYIL LDGDVDALWI ENMNSVMDDN
KLLTLANHER IKLQNHCSLL FEVGDLQYAS PATVSRAGMV YVDPKNLGYQ PYMDKWIQAQ
SKADQDFLRE MCEKYVHGSL RLITEGMLGL QAVEPLQTII PQTGLNMVTQ FCYVFDGLLS
SLKDELTRKK SEVDQEEEDS LLTTKEELWE AMYIQACYWS FGASIVNEAR SKFDEYIKKI
CGLILVQDTP TKPATAKSIP VSFPTIYDYI LDVNKRVWMA WKWLVPAYLH DREKNFSDIL
VQTIDTLRTT WFINLMQNQQ RPVLLVGETG TSKTAIIREF LRNLNPEKYE QLLINFSSRT
TSMDVQRNLE SAVEKRSREI FGAPPGRKLI VFMDDMNMPI VDIYGTQQPI AFLKLLFERG
GFYDRGRDLN WKYLKDIYYL AAMGEPGGSR NEVDPRFISM FSVCNVTFPT SETLNYIYTS
ILSGHLQTFS EAIQSIANGL VQLMLELYKT VRKELLPTPS KFHYIFNMRD LSRIMAGLLQ
SHPDFFSGVK QFVRLWRNEV TRVMCDRLIS VQDENLVIEQ LNGKIRNYWE QEPEVIQYSL
RDPILYGDFR NACNEDEPRF YEDLLDYEAV YNLFLEIFEE YNERNRTKLH MVLFNDALEH
LTRVHRALRM HRGHVLVIGT GGSGKKSVIK LASFAAGYQL FQIVLSRGYN ESFFREDMKN
LYNIVGLENK KVVFMFTSAH IKDESFLELV NSMLTMGFVP ALFNDEEKDT IVTACRDAAV
KAGFDVSKKS VWSYFGKTCT ANLRIALAMS PSGDTLRTRC RNYPGLINNT TIDWMFPWPQ
QALVAVANVF LRDNPIVPQE YKEVIVSHIV YVHTSVLQYT VDFAAKLRRR NYVTPRHFLD
FINTYLKLLV EKKNFINSRC ARLSGGLQKI MEASVTLTEL NKVLAVQRVK VDDQTRSCEL
LLASIGESTD VAMEKKNLSE EKRKEIEDKK KMIAKEEAEA KQALAEAQPV LDAAKLALGE
LEKADITEIR SFATPPEPVQ IVSECVAILR GVKDVSWKGA KGMMSDPYFL RHLQEMNCDQ
ITLRQQQVVR AHLKKTDKLD QMQVISKAGY GLYKFVLAVL DYCAVYREVK PKIDRVQALE
AESEKARRAL EKEERELQRL EKTIQELNAK YDIAMTERQN LQDETDLLQR RLSAADKLIS
GLSSENERWR KDLEILQDDL EKITGNCLLG ASFLAYSGPF SYEFRNEMYS DWERSILEKE
LPLSKPFKLE TQLSDDVEIS KWNSEGLPPD ELSVQNGILT MKASRFPFCI DPQQQALNWI
KKREQKKTLK ILSFTDADFL KQVELAIKYG LPVLVQDADE VDPILVNVLS RNVQTVAGQT
FVIFGDKEID YDPRFRIYLT TKMTNPMLDP ALYAKAVVIN YMVTTAGLEN QLLSVVVRTE
RPDIEEQRET LILETSENKN LLQQLEDSLL REIAADQGTM VDNIELIETL ENIKSSANDV
MKKLLLAEVT SADINKLREN YRPVAERGAI LFSVLVDMAT VNAMYQYSLI SYVEVFIHSL
KRSLPDPVVA KRLKNIIPML TKNVYDYGCT GIFARHKLLF SLQTCVKIEQ SMGNVNQKQL
DFFAKGSTVL ERSPRSNPTR WLPLSGWEDI LKLASGFPEK FEQLPEELRD YEDEWKKWYD
SDTPELEELP CDYSVRLTSF ERLMLIRCFR VDRVYRGIVN YIIEIMGEQY ITPPHVSFDM
IFDESTPTMP VVFILSPGSD PTAELMKLAD RYGCGGGKFR HLSLGQSQDK IAMELLKTAI
TRGQWLMLQN CHLLLSFTKN LEKIVENLEK PHPDFRLWLT TEPTPNFPIG ILQQSLKVVT
EPPSGLKLNL QNTYFNMRPQ LLESCPHPLY KHLIYVLAFY HAVIQERRKY DKIGWNIKYD
FNESDFNVCV TILDTYLTKA LATNESRVPW NSLKYLIGEV MYGGRVIDSY DRRVSYTYMD
EYFGDFLFDE FQPFHFYKDD FVDYVIPPEG GRDDYLRFID ELPLVNSPEV FGLHPNAEIG
YFTQAIKRMW RHLIELQPQT AVSLTGVSKD ESIDNVAREI LTKIPAPYDI SKVKRNFGVA
VTPTAIVLFQ ELERFNKLIE TITRTLNQLR KAIAGEIGMD AVLENISVAL YNGTLPKEWA
RLAPDTRKNL AGWMDHFQKR IDQYTNWSGA NEPVVLWLSG LHVPETYLAA LVQMACRKNN
WPLDRSVIYT TVSKFSKPDD VEERPDQGCY VYGLYLEGAR WDIEEHRLKR SHPKVLIEEL
PILTIVPIEV HRLKLQNTFK TPVYTTSNRL NALGVGLVFE ADLATPEHIS HWILQGVCLV
LNTD
//
