ID A0A6J1R484_9HYME Unreviewed; 852 AA.
AC A0A6J1R484;
DT 07-OCT-2020, integrated into UniProtKB/TrEMBL.
DT 07-OCT-2020, sequence version 1.
DT 18-JUN-2025, entry version 22.
DE SubName: Full=Regulator of G-protein signaling 9 isoform X4 {ECO:0000313|RefSeq:XP_024888988.1};
GN Name=LOC112465603 {ECO:0000313|RefSeq:XP_024888988.1};
OS Temnothorax curvispinosus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Myrmicinae; Temnothorax.
OX NCBI_TaxID=300111 {ECO:0000313|Proteomes:UP000504618, ECO:0000313|RefSeq:XP_024888988.1};
RN [1] {ECO:0000313|RefSeq:XP_024888988.1}
RP IDENTIFICATION.
RC TISSUE=Whole body {ECO:0000313|RefSeq:XP_024888988.1};
RG RefSeq;
RL Submitted (MAR-2025) to UniProtKB.
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DR RefSeq; XP_024888988.1; XM_025033220.1.
DR AlphaFoldDB; A0A6J1R484; -.
DR GeneID; 112465603; -.
DR Proteomes; UP000504618; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter.
DR GO; GO:0043005; C:neuron projection; IEA:TreeGrafter.
DR GO; GO:0005886; C:plasma membrane; IEA:TreeGrafter.
DR GO; GO:0005096; F:GTPase activator activity; IEA:TreeGrafter.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0008277; P:regulation of G protein-coupled receptor signaling pathway; IEA:InterPro.
DR CDD; cd04450; DEP_RGS7-like; 1.
DR CDD; cd00068; GGL; 1.
DR CDD; cd08705; RGS_R7-like; 1.
DR Gene3D; 1.10.1240.60; -; 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR Gene3D; 4.10.260.10; Transducin (heterotrimeric G protein), gamma chain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR015898; G-protein_gamma-like_dom.
DR InterPro; IPR036284; GGL_sf.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR047016; RGS6/7/9/11.
DR InterPro; IPR047017; RGS6/7/9/11_DHEX_sf.
DR InterPro; IPR040759; RGS_DHEX.
DR InterPro; IPR034483; RGS_Egl-10.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR45746; LP21163P; 1.
DR PANTHER; PTHR45746:SF5; REGULATOR OF G-PROTEIN SIGNALING 7; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF00631; G-gamma; 1.
DR Pfam; PF00615; RGS; 1.
DR Pfam; PF18148; RGS_DHEX; 1.
DR PRINTS; PR01301; RGSPROTEIN.
DR SMART; SM00049; DEP; 1.
DR SMART; SM01224; G_gamma; 1.
DR SMART; SM00224; GGL; 1.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR SUPFAM; SSF48670; Transducin (heterotrimeric G protein), gamma chain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50186; DEP; 1.
DR PROSITE; PS50132; RGS; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000504618};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700}.
FT DOMAIN 35..110
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 311..427
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
FT REGION 450..484
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 535..572
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 617..637
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 763..821
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 451..460
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 551..562
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 622..634
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 763..772
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 852 AA; 95729 MW; 142F469E18E66963 CRC64;
MEASSNQQQK EKEPRVHRPY AFDKMEGLVR EMQDPERGVP VRSQKQFLTS IPSAFMGYDL
IEWLMDRLAI EESEAVHIAN QLCQYGYFFP VNDSKTLTVK DDSSLYRFQT PYYWPWQHRT
PDNVEYAIYL AKRTLRNKQR HALEDYEIEA LNSLRKNLQN KWDIIQLQAE EQVRLSKERK
KGDKIVSDSQ ERAFWRVYRP PPGCLSSLEV VPVPTRFRPG LPRPPSRKRT LTDLQREVAL
LRNSLTRTRI KVSTAIENFK SYFETYVEYD PMFVQPQPSN PWITDDHMFW QLNSPLVEVP
TEKRVKRWAL SMEELMSDPT GLQEFTNYLR KEYSHENIRF WLAVKDLRHS FQAQIPDKVN
EIFREFLAPG APCEINIDGK TMEKVHQEMK NPSRFTFDSA AEHVYTLLLK KDCYPRFIRS
DQYRNLLAAG VQPLQKKRFF GFGGQAKKKV SSTSTPTSST LQHANIGGGS GGGRRRGSDR
SLSGSAHELA ICGVRDVTSA PRVPHSHSQS NLTDIPYRDA GATEVVVRPM DDVCPWEAVP
GPSTEPGGTG DTASSGRTAS ADQTRHVWDS GGYSTTTYSA EAARASRKNS AQLDSCSSSS
DVSLAIADVS ERLRKSCSLQ HSGSVGTSTS GPSTITRNYS TCSASGRIRL AEIGRASVSS
CNYPSPQQSF EYSHAVVERV VEKLEERSSL EKIVPEEETV AEAIVEKESQ SSPKTTAKAP
LISISAIVGD LPSDNSTMEN IDEDGSESCT AKDAGEIVAE EKLKGEDSRA DTGADVSPVA
EEPATTEELP EETQVMPVWE PDAQQEDRPA VAQAVPREKR DNNVNEVCPW EDEENCRVDA
PYVKTYATLG YL
//
