ID A0A6J1RZT0_FRAOC Unreviewed; 519 AA.
AC A0A6J1RZT0;
DT 07-OCT-2020, integrated into UniProtKB/TrEMBL.
DT 07-OCT-2020, sequence version 1.
DT 18-JUN-2025, entry version 22.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=LOC113202194 {ECO:0000313|RefSeq:XP_026272086.1};
OS Frankliniella occidentalis (Western flower thrips) (Euthrips occidentalis).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Thysanoptera; Terebrantia; Thripoidea; Thripidae;
OC Frankliniella.
OX NCBI_TaxID=133901 {ECO:0000313|Proteomes:UP000504606, ECO:0000313|RefSeq:XP_026272086.1};
RN [1] {ECO:0000313|RefSeq:XP_026272086.1}
RP IDENTIFICATION.
RC TISSUE=Whole organism {ECO:0000313|RefSeq:XP_026272086.1};
RG RefSeq;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP +
CC H(+); Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00048679};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] +
CC ADP + H(+); Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-
CC COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00047899};
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr
CC protein kinase family. SNF1 subfamily. {ECO:0000256|ARBA:ARBA00006234}.
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DR RefSeq; XP_026272086.1; XM_026416301.2.
DR AlphaFoldDB; A0A6J1RZT0; -.
DR GeneID; 113202194; -.
DR KEGG; foc:113202194; -.
DR OrthoDB; 193931at2759; -.
DR Proteomes; UP000504606; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-ARBA.
DR GO; GO:0004679; F:AMP-activated protein kinase activity; IEA:UniProtKB-ARBA.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:TreeGrafter.
DR CDD; cd12122; AMPKA_C; 1.
DR CDD; cd14079; STKc_AMPK_alpha; 1.
DR CDD; cd14336; UBA_AID_AMPKalpha; 1.
DR FunFam; 1.10.510.10:FF:000079; Non-specific serine/threonine protein kinase; 1.
DR FunFam; 1.10.8.10:FF:000055; Non-specific serine/threonine protein kinase; 1.
DR FunFam; 3.30.200.20:FF:000136; Non-specific serine/threonine protein kinase; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR Gene3D; 3.30.310.80; Kinase associated domain 1, KA1; 1.
DR Gene3D; 3.30.200.20; Phosphorylase Kinase, domain 1; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR032270; AMPK_C.
DR InterPro; IPR028375; KA1/Ssp2_C.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR049020; PRKAA1/2_AID.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR24346; MAP/MICROTUBULE AFFINITY-REGULATING KINASE; 1.
DR PANTHER; PTHR24346:SF110; NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE; 1.
DR Pfam; PF16579; AdenylateSensor; 1.
DR Pfam; PF21147; AMPK_alpha_AID; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF103243; KA1-like; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|RefSeq:XP_026272086.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000504606};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 22..274
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT BINDING 51
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 519 AA; 58968 MW; 7F97EC6694456361 CRC64;
MASIEKTTTQ LAPQPIVKIG HYTLGQTLGV GTFGKVKIGE HQLTKHKVAV KILNRQKIKS
LDVVGKIRRE IQNLKLFRHP HIIKLYQVIS TPTDIFMIME YVSGGELFDY IVKHGKLKEH
EARRFFQQII SGVDYCHRHM IVHRDLKPEN LLLDQNLHVK IADFGLSNMM MDGEFLRTSC
GSPNYAAPEV ISGKLYAGPE VDIWSCGVIL YALLCGTLPF DDEHVPTLFR KIKSGIFPIP
DYLNKSVVSL LCHMMHIDPM KRATIEDIKK HEWFQKDLPA YLFPSPVEQD SSVIDTEAIT
EVCEKFAVKE CEVHNALLSG DPHDQLGIAY HLVIDNKRIA DEAAKAELKD FYVASSPPPV
QFEFSPSPVR PHPERIAPTF RSRVPSIDRS SQGDAAIRSA PVKRAKWHLG IRSQSKPNDI
MNEVYRAMKV LNFEWKVINA YHVRVRQMSV SNPEKYIKMS LQLYQVDYKS YLLDFKSLSS
DEPECNLADT SSVAPTQSTG HHTMEFFEMC AALITQLAR
//
