ID   A0A6J1V3R9_9SAUR        Unreviewed;       599 AA.
AC   A0A6J1V3R9;
DT   07-OCT-2020, integrated into UniProtKB/TrEMBL.
DT   07-OCT-2020, sequence version 1.
DT   28-JAN-2026, entry version 24.
DE   RecName: Full=5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase {ECO:0000256|ARBA:ARBA00026102};
DE            EC=3.6.1.62 {ECO:0000256|ARBA:ARBA00026102};
GN   Name=DCP1B {ECO:0000313|RefSeq:XP_026534474.1};
OS   Notechis scutatus (mainland tiger snake).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Elapidae; Hydrophiinae; Notechis.
OX   NCBI_TaxID=8663 {ECO:0000313|Proteomes:UP000504612, ECO:0000313|RefSeq:XP_026534474.1};
RN   [1] {ECO:0000313|RefSeq:XP_026534474.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (AUG-2025) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside
CC         in mRNA + H2O = N(7)-methyl-GDP + a 5'-end phospho-ribonucleoside in
CC         mRNA + 2 H(+); Xref=Rhea:RHEA:67484, Rhea:RHEA-COMP:15692, Rhea:RHEA-
CC         COMP:17167, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:63714,
CC         ChEBI:CHEBI:138282, ChEBI:CHEBI:156461; EC=3.6.1.62;
CC         Evidence={ECO:0000256|ARBA:ARBA00047661};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67485;
CC         Evidence={ECO:0000256|ARBA:ARBA00047661};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC       Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the DCP1 family.
CC       {ECO:0000256|ARBA:ARBA00008778}.
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DR   RefSeq; XP_026534474.1; XM_026678689.1.
DR   AlphaFoldDB; A0A6J1V3R9; -.
DR   GeneID; 113419360; -.
DR   KEGG; nss:113419360; -.
DR   CTD; 196513; -.
DR   Proteomes; UP000504612; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000932; C:P-body; IEA:TreeGrafter.
DR   GO; GO:0140933; F:5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008047; F:enzyme activator activity; IEA:InterPro.
DR   GO; GO:0003729; F:mRNA binding; IEA:TreeGrafter.
DR   GO; GO:0000290; P:deadenylation-dependent decapping of nuclear-transcribed mRNA; IEA:InterPro.
DR   GO; GO:0031087; P:deadenylation-independent decapping of nuclear-transcribed mRNA; IEA:TreeGrafter.
DR   GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:UniProtKB-KW.
DR   CDD; cd13182; EVH1-like_Dcp1; 1.
DR   FunFam; 2.30.29.30:FF:000097; Putative mRNA-decapping enzyme 1A; 1.
DR   Gene3D; 6.10.140.2030; -; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR010334; Dcp1.
DR   InterPro; IPR031953; mRNA_decap_C.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   PANTHER; PTHR16290:SF5; MRNA-DECAPPING ENZYME 1B; 1.
DR   PANTHER; PTHR16290; TRANSCRIPTION FACTOR SMIF DECAPPING ENZYME DCP1; 1.
DR   Pfam; PF06058; DCP1; 1.
DR   Pfam; PF16741; mRNA_decap_C; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nonsense-mediated mRNA decay {ECO:0000256|ARBA:ARBA00023161};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000504612}.
FT   DOMAIN          557..597
FT                   /note="mRNA-decapping enzyme C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16741"
FT   REGION          399..429
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   599 AA;  66111 MW;  6A80AD13922516A4 CRC64;
     MAASVAGAAP LGKGLDISLA ALQRHDPYIS SILDVASQVA LYTFGHRANE WEKTDVEGTL
     FVCTRSASPK YGFTIMNRLS MENRTEPITK DLDFQLQDPF LLYRNAKLSI YGIWFYDKEE
     CQRIAELMKN LTRQEQLKAQ QGSGIGISPV SLSSGDRKDV DILQMLNRAK YEYTKCKTCS
     EPKPMTSSSA LYHNPNLIKP IPLKPRESQN VQNTDSEPQH LSLMTLFGKQ EKSSLYQNVS
     EPPQKLHPDN FPPRQGVVRS FSYEEPTRHS PTTEKQLCPA IQKLMVRGPE LHPVSELPEN
     RLCENGSHPS MGGEAFAGLF QPVTSQSTGS SHPAQNAACT RRLLQQLQGQ SKQMTKVETN
     SIGLANSAAP GFSRTPAISL VAQVNSVIQP PMMYFNGSLP SQALGKEQSK PPKQSHPLPG
     NHSGNSGVIS PQELLKKLQI VQQEQQLHIA SRPTLAAKFP VVTQASTTLK PLDSWMDKAS
     ATEKQPPLLQ VISPQWIPAT IAPSLLMSPM VFSQSAPQLP KPNESRWLPV MNQESTSGSA
     NLLLPLQNSE ATIPKSNPLT KLQLQETLLH LIQNDDNFLN VIYDAYLGSV RKATLKKPI
//