ID A0A6J1VX81_9SAUR Unreviewed; 1463 AA.
AC A0A6J1VX81;
DT 07-OCT-2020, integrated into UniProtKB/TrEMBL.
DT 07-OCT-2020, sequence version 1.
DT 18-JUN-2025, entry version 22.
DE RecName: Full=Nuclear receptor coactivator {ECO:0000256|PIRNR:PIRNR038181};
GN Name=NCOA2 {ECO:0000313|RefSeq:XP_026547601.1};
OS Notechis scutatus (mainland tiger snake).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Hydrophiinae; Notechis.
OX NCBI_TaxID=8663 {ECO:0000313|Proteomes:UP000504612, ECO:0000313|RefSeq:XP_026547601.1};
RN [1] {ECO:0000313|RefSeq:XP_026547601.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR038181}.
CC -!- SIMILARITY: Belongs to the SRC/p160 nuclear receptor coactivator
CC family. {ECO:0000256|ARBA:ARBA00009933, ECO:0000256|PIRNR:PIRNR038181}.
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DR RefSeq; XP_026547601.1; XM_026691816.1.
DR GeneID; 113429264; -.
DR Proteomes; UP000504612; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0016922; F:nuclear receptor binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0003713; F:transcription coactivator activity; IEA:InterPro.
DR GO; GO:0032870; P:cellular response to hormone stimulus; IEA:TreeGrafter.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:TreeGrafter.
DR GO; GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
DR CDD; cd18950; bHLH-PAS_NCoA2_SRC2; 1.
DR CDD; cd00130; PAS; 1.
DR FunFam; 3.30.450.20:FF:000007; Nuclear receptor coactivator; 1.
DR FunFam; 3.30.450.20:FF:000008; Nuclear receptor coactivator; 1.
DR FunFam; 4.10.280.10:FF:000008; Nuclear receptor coactivator; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR Gene3D; 6.10.140.20; Nuclear receptor coactivator, Ncoa-type, interlocking domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR056193; bHLH_NCOA1-3.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR010011; NCO_DUF1518.
DR InterPro; IPR032565; NCOA2/3_DUF4927.
DR InterPro; IPR028822; NCOA2_bHLH.
DR InterPro; IPR009110; Nuc_rcpt_coact.
DR InterPro; IPR014920; Nuc_rcpt_coact_Ncoa-typ.
DR InterPro; IPR037077; Nuc_rcpt_coact_Ncoa_int_sf.
DR InterPro; IPR017426; Nuclear_rcpt_coactivator.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR InterPro; IPR014935; SRC/p160_LXXLL.
DR PANTHER; PTHR10684; NUCLEAR RECEPTOR COACTIVATOR; 1.
DR PANTHER; PTHR10684:SF2; NUCLEAR RECEPTOR COACTIVATOR 2; 1.
DR Pfam; PF23172; bHLH_NCOA; 1.
DR Pfam; PF07469; DUF1518; 1.
DR Pfam; PF16279; DUF4927; 1.
DR Pfam; PF16665; NCOA_u2; 1.
DR Pfam; PF08815; Nuc_rec_co-act; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF14598; PAS_11; 1.
DR Pfam; PF08832; SRC-1; 1.
DR PIRSF; PIRSF038181; Nuclear_receptor_coactivator; 1.
DR SMART; SM01151; DUF1518; 1.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00091; PAS; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF69125; Nuclear receptor coactivator interlocking domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS50112; PAS; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159, ECO:0000256|PIRNR:PIRNR038181};
KW Biological rhythms {ECO:0000256|ARBA:ARBA00023108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR038181};
KW Receptor {ECO:0000313|RefSeq:XP_026547601.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000504612};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|PIRNR:PIRNR038181};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|PIRNR:PIRNR038181}.
FT DOMAIN 26..83
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 119..182
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 426..508
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 555..630
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 708..731
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 843..863
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..11
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 437..484
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 559..569
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 620..630
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 844..863
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1463 AA; 159899 MW; 1D9AC47E84F16766 CRC64;
MSGIGENSSD PSRAEQRKRK ECPDQLGPSP KRSTEKRNRE QENKYIEELA ELIFANFNDI
DNFNFKPDKC AILKETVKQI RQIKEQEKAA AANEDEVQKA DVSSTGQSVI DKDALGPMML
EALDGFFFVV NVEGNVVFVS ENVTQYLRYN QEELMNTRVY NILHVGDHNE FIKNLPKSMV
NGGPCYGESP RRNSHTFNCR MLVKPLTDSE EEGHENQEAH LKYETMQCFA VSQPKSIKED
GEDLQSCLIC VARRVPMKER PFLPFSETFS TRHDLQGKIT SLDTSTMRAA MKPGWEDVVR
RCIQRFYAQH EGDISFAKRH HQEVLRQGLA LSPVYRFSLS DGTIVGAQTK SKLVRSQTTS
EPQHVISLHM LHREQNVCGM NQDLTGQVLG KPLNTISSNS PAHQAMCSGN PGQDMTINSN
MNFAINGPKE QMGMPTSRFS SSGGMNHVSS IQTSAPQGSN YALKMNSPSQ NSPGMTPGQP
NSMLSPRHRM SPGVAGSPRI PPNQFSPAGS LHSPVGVCSS TGNSHSYTNS SLNALQALSE
GHGVSLGSSL ASPDVKMGNL QNSPVSMNPP QLAKMGNLDS KDSFGLHGEQ SEETTGQTEN
VCHSGEQKEN NDNMPQVGSE RPDGQNRLHD GKSQTKLLQL LTTKSDQMEP SSLANTMGDA
NKDSMGSLSG SGAAHGTSLK EKHKILHRLL QDSNSPIDLA KLTAEATGKE LNQETSSTAP
GSEITCKQEP VSPKKKENAL LRYLLDKDDT KEIGLPDITP KLERLDSKTD PSSSTVKPIA
MKTEKEEMRF EPNEQPGSEL DNLEEILDDL QNSQLSQLFP DTRPVASAGS VDKQAIINDL
MQITGDNSPG TPVGSQKPTG RISQSTFTNA RQAQLGRMLP NQNLQLDIAL QNPPGAATFP
PIRNNSPYSV IPQPSMLGSQ GMMGSQGNLG NNNPGMIAGN TPRPAMSSGD WGSQAAAVRV
TCAATTSAMN RPIQGGMIRN PTSSLPMRPN SQAVPRQILQ SQVMNMGGSE LEMNMGAPQY
TQQQAPPNQT APWPDSILPI DQASFSNQNR QPFVGSPDDL MCQRPASESP SDEGALLDQL
YMALRNFDGL EEIDRALGIP ELVSQQTQGV DPESFSNQEP NIILEQKASV FTQQYASQAQ
MAQGNYTPLQ DPNFHPMAQR PGYAALRMQP RPGLRPTGLV QNPPNQLRLQ LQHRLQAQQN
RQPLINQIGN VSSMNLSLRP GVPTQVREQG NINSQMLAQR QREILSQHLR HRQMHQVQQR
TLMMRGQSMN MTPSMVASGG IPATMSNPRI PQTNPQQFPF PPNYGINQQP DSGFTGATTP
QSPLMSPRMA HTQNPLIQQS QANPAYQSST EINGWGQGNI GGNSMFSQQS PPHFGQQANT
SMYNNNMNIN VSMVANSAGL NNMNQMTGQI NMTSATSVPT SGLPSMGPEQ VNDPAMRGGS
LFPNQLPGMD MIKQEGDASR KYC
//
