ID A0A6J1XY86_ACIJB Unreviewed; 1306 AA.
AC A0A6J1XY86;
DT 07-OCT-2020, integrated into UniProtKB/TrEMBL.
DT 08-OCT-2025, sequence version 2.
DT 28-JAN-2026, entry version 23.
DE SubName: Full=Collagen alpha-1(XVIII) chain isoform X5 {ECO:0000313|RefSeq:XP_026897210.2};
GN Name=COL18A1 {ECO:0000313|RefSeq:XP_026897210.2};
OS Acinonyx jubatus (Cheetah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae;
OC Acinonyx.
OX NCBI_TaxID=32536 {ECO:0000313|Proteomes:UP001652583, ECO:0000313|RefSeq:XP_026897210.2};
RN [1] {ECO:0000313|RefSeq:XP_026897210.2}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_026897210.2};
RG RefSeq;
RL Submitted (AUG-2025) to UniProtKB.
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DR RefSeq; XP_026897210.2; XM_027041409.2.
DR GeneID; 106985669; -.
DR Proteomes; UP001652583; Chromosome C2.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR GO; GO:0031012; C:extracellular matrix; IEA:TreeGrafter.
DR GO; GO:0005615; C:extracellular space; IEA:TreeGrafter.
DR GO; GO:0030020; F:extracellular matrix structural constituent conferring tensile strength; IEA:TreeGrafter.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0032836; P:glomerular basement membrane development; IEA:TreeGrafter.
DR CDD; cd00247; Endostatin-like; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 3.40.1620.70; -; 1.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR050149; Collagen_superfamily.
DR InterPro; IPR010515; Collagenase_NC10/endostatin.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR048287; TSPN-like_N.
DR InterPro; IPR045463; XV/XVIII_trimerization_dom.
DR PANTHER; PTHR24023:SF1112; COL_CUTICLE_N DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR PANTHER; PTHR24023; COLLAGEN ALPHA; 1.
DR Pfam; PF01391; Collagen; 4.
DR Pfam; PF20010; Collagen_trimer; 1.
DR Pfam; PF06482; Endostatin; 1.
DR SMART; SM00210; TSPN; 1.
DR SUPFAM; SSF56436; C-type lectin-like; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
PE 4: Predicted;
KW Collagen {ECO:0000256|ARBA:ARBA00023119,
KW ECO:0000313|RefSeq:XP_026897210.2};
KW Reference proteome {ECO:0000313|Proteomes:UP001652583};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..33
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 34..1306
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5046570310"
FT DOMAIN 41..229
FT /note="Thrombospondin-like N-terminal"
FT /evidence="ECO:0000259|SMART:SM00210"
FT REGION 232..991
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1061..1080
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 256..266
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 272..282
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 305..323
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 333..345
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 346..361
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 366..382
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 411..425
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 455..465
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 481..499
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 500..509
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 510..519
FT /note="Gly residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 520..554
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 556..571
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 646..660
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 668..677
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 804..819
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 833..847
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 872..892
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 904..916
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 946..962
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 972..984
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1306 AA; 132607 MW; 079817500E902391 CRC64;
MAPRWPWLRP RPRSLLDVLA PLVLLLGVRA ASADPESLGT EVGLLQLLGE PPPQQVAQVD
DPDVGPAFVF GPDANSGQVA RYHFPSPFFR DFSLLFHVRP ATEGAGVLFA ITDAAQAVVS
VGVKLSAVRD GQQHIQLLYT EPGATRTHTA ASFRLPAFTG QWTRFALSVD GATVALFVDC
ELFQRVPLVR SPRALELEPG AGLFVAQAGG ADPSKFQGRI AELRVRGDPR VSPLHCLEED
DEDSGGVSGD FGSGLEENRE LLREQSRLSP KPSLPEAPPV TSPPLAGGRN VEDSRTEEIE
EETTMSSLGA WTLPGSDTVT AWSVRSPGGG PEEGPAGSAV QSPDAQPVPG PQGPPGPPGP
PGKDGAPGKD GEPGDPGEDG KPGDPGPQGF PGTPGDMGPK GEKGDPGVGP RGPPGPQGPP
GPPGPSFRHD RLTFIDMEGS GFGGDLESLR GPRGFPGPPG PPGVPGLPGE PGRFGMNSSD
VPGPAGLPGV PGRDGAPGLP GAPGPPGPPG RDGGPGKTGQ KGSPGEAGAP GPKGSKGDPG
PTGAPGETGL AGAPGPAGPP GPPGPPGPPG PGLAAGFEDM DGSGGPFWST AHGASGPQGP
PGLPGVKGDP GIAGPPGAKG EVGADGPPGF PGLPGREGTA GAQGPKGEKG TQGEKGDPGR
DGVGQPGLPG PPGPPGPVVY VSEQDRAVAG VPGPEGRPGY AGFPGPAGPK GDLGSKGQRG
PPGPKGEKGE PGPVFSPDGG TLGPAQKGAK GEPGFRGPPG PYGRPGHKGE IGFPGRPGRP
GMNGLKGEKG EPGHASVGFG VRGPPGPPGP PGPPGPPGTP VYDSNDFMES GRPGPPGLPG
YQGPPGPKGD KGEVGPPGPP GQFPLDLLQL EAEMKGEKGD RGDPGQKGER GEPGGGGFFG
SSVPGPPGPP GYPGIPGPKG ESIRGQPGPP GPQGPPGIGH EGRQGPPGPP GPPGPPGPPS
FPGPYRQTIS VPGPPGPPGP PGPPGTMGTS SGQVRIWATY QTMLDKVPEV PEGWLIFVAE
TEELYVRVRN GFRKVLLEAR TPLPRGTDNE VAALQPPLVQ LHEGNPYPRR ELTHSTARPW
RADDILAGPP RLPDPRPYPG APHHGPYLHV QPARPTGGPA RTHTHQDFQP VLHLVALNSP
QPGGMRGIRG ADFQCFQQAR AVGLAGTFRA FLSSRLQDLY SIVRRADRTG VPIVNLRDEV
LFPSWEALFS GSEGQLKPGA RVFSFDGRDV LQHPAWPQKS VWHGSDPSGR RLTDSYCETW
RTEDAAAAGQ ASSLLAGRLL AQKAASCRNA FIVLCIENSF MTSSSK
//
