ID A0A6J1YS68_ACIJB Unreviewed; 810 AA.
AC A0A6J1YS68;
DT 07-OCT-2020, integrated into UniProtKB/TrEMBL.
DT 07-OCT-2020, sequence version 1.
DT 28-JAN-2026, entry version 23.
DE SubName: Full=RING finger protein unkempt homolog isoform X4 {ECO:0000313|RefSeq:XP_026908027.1};
GN Name=UNK {ECO:0000313|RefSeq:XP_026908027.1};
OS Acinonyx jubatus (Cheetah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae;
OC Acinonyx.
OX NCBI_TaxID=32536 {ECO:0000313|Proteomes:UP001652583, ECO:0000313|RefSeq:XP_026908027.1};
RN [1] {ECO:0000313|RefSeq:XP_026908027.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_026908027.1};
RG RefSeq;
RL Submitted (AUG-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the unkempt family.
CC {ECO:0000256|ARBA:ARBA00008808}.
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DR RefSeq; XP_026908027.1; XM_027052226.2.
DR AlphaFoldDB; A0A6J1YS68; -.
DR GeneID; 106987748; -.
DR CTD; 85451; -.
DR Proteomes; UP001652583; Chromosome E1.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:1990715; F:mRNA CDS binding; IEA:TreeGrafter.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR GO; GO:0048667; P:cell morphogenesis involved in neuron differentiation; IEA:TreeGrafter.
DR CDD; cd16771; RING-HC_UNK; 1.
DR Gene3D; 4.10.1000.10; Zinc finger, CCCH-type; 2.
DR InterPro; IPR040594; UNK_Znf_1.
DR InterPro; IPR057295; UNK_Znf_4.
DR InterPro; IPR057296; UNK_Znf_5.
DR InterPro; IPR045234; Unkempt-like.
DR InterPro; IPR000571; Znf_CCCH.
DR InterPro; IPR036855; Znf_CCCH_sf.
DR PANTHER; PTHR14493:SF36; RING FINGER PROTEIN UNKEMPT HOMOLOG; 1.
DR PANTHER; PTHR14493; UNKEMPT FAMILY MEMBER; 1.
DR Pfam; PF00642; zf-CCCH; 1.
DR Pfam; PF23261; zf-CCCH_11; 1.
DR Pfam; PF25427; zf-CCCH_UNK; 1.
DR Pfam; PF23035; zf-CCCH_UNK-like_4th; 1.
DR Pfam; PF18384; zf_CCCH_5; 1.
DR SMART; SM00356; ZnF_C3H1; 5.
DR SUPFAM; SSF90229; CCCH zinc finger; 1.
DR PROSITE; PS50103; ZF_C3H1; 4.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU00723}; Reference proteome {ECO:0000313|Proteomes:UP001652583};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00723};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00723}.
FT DOMAIN 84..113
FT /note="C3H1-type"
FT /evidence="ECO:0000259|PROSITE:PS50103"
FT DOMAIN 124..154
FT /note="C3H1-type"
FT /evidence="ECO:0000259|PROSITE:PS50103"
FT DOMAIN 251..285
FT /note="C3H1-type"
FT /evidence="ECO:0000259|PROSITE:PS50103"
FT DOMAIN 293..321
FT /note="C3H1-type"
FT /evidence="ECO:0000259|PROSITE:PS50103"
FT ZN_FING 84..113
FT /note="C3H1-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00723"
FT ZN_FING 124..154
FT /note="C3H1-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00723"
FT ZN_FING 251..285
FT /note="C3H1-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00723"
FT ZN_FING 293..321
FT /note="C3H1-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00723"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 239..265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 647..723
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 10..19
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 241..253
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 810 AA; 88216 MW; 39F91B48AD36537B CRC64;
MSKGPGPGGS AASSAPPAAT AQVLQAQPEK PQHYTYLKEF RTEQCPLFVQ HKCTQHRPYT
CFHWHFVNQR RRRSIRRRDG TFNYSPDVYC TKYDEATGLC PEGDECPFLH RTTGDTERRY
HLRYYKTGIC IHETDSKGNC TKNGLHCAFA HGPHDLRSPV YDIRELQAME ALQNGQTTVE
GSIEGQTAGA ASHAMIEKIL SEEPRWQETA YVLGNYKTEP CKKPPRLCRQ GYACPYYHNS
KDRRRSPRKH KYRSSPCPNV KHGDEWGDPG KCENGDACQY CHTRTEQQFH PEIYKSTKCN
DMQQSGSCPR GPFCAFAHVE QPPLSDDLQP SSTVSSPTQP GPVLYMPSAA GDSVPVSPSS
PHAPDLSALL CRNSNLGSPS NLCGSPPGSI RKPPNLEGIV FPGESGLAPG SYKKAPGFER
EDQVGAEYLK NFKCQAKLKP HSLEPRSQEQ PLLQPKQDML GILPVGSPLT SSISSSITSS
LAATPPSPAG TSSVPGMNAN ALPFYPTSDT VESVIESALD DLDLNEFGVA ALEKTFDNTT
VPHPGSITIG GSLLQSSAPV NIPGSLGSSA SFHSASPSPP VSLSSHFLQQ PQGHLSQSEN
TFLGTSASHG SLGLNGMNSS IWEHFASGSF SPGTSPAFLS GPGAAELARL RQELEEANST
IKQWEESWKQ AKQACDAWKK EAEEAGERAS AAGAECELAR EQRDALEEQV KKLQEELERL
HSGPDPQALP TFSDLEALSL STLYSLQKQL RAHLEQVDKA VFHMQSVKCL KCQEQNRAVL
PCQHAVLCEL CAEGSECPVC QPGRAHALQS
//
