ID A0A6J1ZE98_ACIJB Unreviewed; 3548 AA.
AC A0A6J1ZE98;
DT 07-OCT-2020, integrated into UniProtKB/TrEMBL.
DT 07-OCT-2020, sequence version 1.
DT 08-OCT-2025, entry version 23.
DE RecName: Full=WD repeat and FYVE domain-containing protein 3 {ECO:0000256|ARBA:ARBA00069628};
GN Name=WDFY3 {ECO:0000313|RefSeq:XP_026915757.1,
GN ECO:0000313|RefSeq:XP_026915762.1, ECO:0000313|RefSeq:XP_026915772.1,
GN ECO:0000313|RefSeq:XP_026915784.1, ECO:0000313|RefSeq:XP_053073136.1,
GN ECO:0000313|RefSeq:XP_053073137.1, ECO:0000313|RefSeq:XP_053073138.1};
OS Acinonyx jubatus (Cheetah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae;
OC Acinonyx.
OX NCBI_TaxID=32536 {ECO:0000313|Proteomes:UP001652583, ECO:0000313|RefSeq:XP_026915762.1};
RN [1] {ECO:0000313|RefSeq:XP_026915757.1, ECO:0000313|RefSeq:XP_026915762.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_026915757.1,
RC ECO:0000313|RefSeq:XP_026915762.1};
RG RefSeq;
RL Submitted (APR-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, axon
CC {ECO:0000256|ARBA:ARBA00004489}. Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}. Nucleus, PML body
CC {ECO:0000256|ARBA:ARBA00004322}. Perikaryon
CC {ECO:0000256|ARBA:ARBA00004484}.
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DR RefSeq; XP_026915757.1; XM_027059956.1.
DR RefSeq; XP_026915762.1; XM_027059961.1.
DR RefSeq; XP_026915772.1; XM_027059971.1.
DR RefSeq; XP_026915784.1; XM_027059983.1.
DR RefSeq; XP_053073136.1; XM_053217161.1.
DR RefSeq; XP_053073137.1; XM_053217162.1.
DR RefSeq; XP_053073138.1; XM_053217163.1.
DR GeneID; 106981373; -.
DR KEGG; aju:106981373; -.
DR CTD; 23001; -.
DR Proteomes; UP001652583; Chromosome B1.
DR GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043204; C:perikaryon; IEA:UniProtKB-SubCell.
DR GO; GO:0016605; C:PML body; IEA:UniProtKB-SubCell.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR GO; GO:0035973; P:aggrephagy; IEA:TreeGrafter.
DR CDD; cd06071; Beach; 1.
DR CDD; cd15719; FYVE_WDFY3; 1.
DR CDD; cd01201; PH_BEACH; 1.
DR FunFam; 3.30.40.10:FF:000028; Putative hepatocyte growth factor-regulated tyrosine kinase substrate; 1.
DR FunFam; 1.10.1540.10:FF:000002; WD repeat and FYVE domain containing 3; 1.
DR FunFam; 2.30.29.30:FF:000095; WD repeat and FYVE domain containing 3; 1.
DR FunFam; 2.130.10.10:FF:000293; WD repeat and FYVE domain-containing protein 3; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR056252; Alfy-like_Arm-like.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR051944; BEACH_domain_protein.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46108; BLUE CHEESE; 1.
DR PANTHER; PTHR46108:SF1; WD REPEAT AND FYVE DOMAIN-CONTAINING PROTEIN 3; 1.
DR Pfam; PF23295; Arm_4; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF14844; PH_BEACH; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00064; FYVE; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Autophagy {ECO:0000256|ARBA:ARBA00023006};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP001652583};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 2553..2678
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 2705..2998
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REPEAT 3145..3186
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 3476..3536
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT REGION 2428..2450
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2481..2544
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2993..3018
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3295..3336
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2490..2499
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2993..3002
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3006..3018
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3300..3312
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3548 AA; 397571 MW; B348FB9B7D8DA5CE CRC64;
MNMVKRIMGR PRQEECSPQD NALGLMHLRR LFTELCHPPR HMTQKEQEEK LYMMLPVFNR
VFGNAPPNTM TEKFSDLLQF TTQVSRLMVT EIRRRASNKS TEKQCVPLSS KDFTATTPSE
AASRAIVQFL EINQSEEASR GWMLLTTINL LASSGQKTVD CMTTMSVPST LVKCLYLFFD
LPHVPEAVGG AQNELPLAER RGLLQKVFVQ ILVKLCSFVS PAEELAQKDD LQLLFSAITS
WCPPYNLPWR KSAGEVLMTI SRHGLSVNVV KYIHEKECLS TCVQNMQQSD DLSPLEIVEM
FAGLSCFLKD SSDVSQTLLD DFRIWQGYNF LCDLLLRLEQ AKEAESKDAL KDLVNLITSL
TTYGVNELKP AGITTGAPFL LPGFAVPQPA GKGHSVRNIQ AFAVLQNAFL KAKTNFLAQI
ILDAITNIYM ADNANYFILE SQHTLSQFAE KISKLPEVQS KYFEMLEFVV FSLNYIPCKE
LISVSILLKS SSSYHCSIIA MKTLLKFTRH DYIFKDVFRE VGLLEVMVNL LHKYAALLKD
PTQALNEQGD SRNNSSVEDQ KHLALLVMET LTVLLQGSNT NAGIFREFGG ARCAHNIVKY
PQCRQHALMI IQQLVLSPNG EDDMGTLLGL MHSAPPTELQ LKTDILRALL SVLRESHRSR
TVFRKVGGFV YITSLLVAME RSLSSPPKNG WEKVNQNQVF ELLHTVFCTL TAAMRYEPAN
SHFFKTEIQY EKLADAVRFL GCFSDLRKIS PMNVFPSNTQ PFQRLLEEDV ISMDTVSPTL
RHCSKLFIYL YKVATDSFDS RAEQIPPCLT SESSLPSPWG TPALSRKRHA YHSVSTPPVY
PPKNVADLKL HVATTSFQSS DAVIIHPGAM LAMLDLLASV GSVTQPEHAL DLQLAVANIL
QALVHTERNQ QVMCEAGLHA RLLQRCSAAL ADEDHSLHPP LQRMFERLAS QALEPMVLRE
FLRLASPLNC GAWDKKLLKQ YRVHKPSSLS YEPEMRSSMI TSMEGLGSDN VFSLHEDNHY
RISKSLVKSA EGSTVPLTRV KCLVSMTTPH DIRLHGSSVT PAFVEFDTSL EGFGCLFLPS
LAPHNAPTNN AVTTGLTDGA VVSGIGSGER FFPPPSGLSY SSWFCIEHFS SPPNNHPVRL
LTIVRRANSS EQHYVCLAVV LSAKDRSLIV STKEELLQNY VDDFSEESSF YEILPCCARF
RCGELIVEGQ WHHLVLVMSK GMLKNSTAAL YIDGQLVNTV KLHYVHSTPG GSGSANPPVV
STVYAYVGTP PAQRQIASLV WRLGPTHFLE EVLPPSNVTT IYELGPNYVG SFQAVCMPCK
DAKSEGVVPS PVSLVPEEKV SFGLYALSVS SLTVARIRKV YNKLDSKAIA KQLGISSHEN
ATPVKLIHNS AGHLNGPART VGATLIGYLG VRTFVPKPVA TTLQYIGGAA AILGLVAMAS
DVEGLYAAVK ALVCVVKSNP LASKEMERIK GYQLLAMLLK KKRSLLNSHI LHLTFSLVGT
VDSGHETSII PNSTAFQDLL CDFEVWLHAP YELHLSLFEH FIELLTESSE ASKNAKLMRE
FQLIPKLLLT LRDMSLSQPT IAAISNVLSF LLQGFPNSND LLRFGQFISS TLPTFAVCEK
FVVMEINNEE KLDTGTEEDF GGLVSANLIL LRNRLLDILL KLVYTSKEKT SINLQACEEL
VRTLGFDWIM MFMEEHLHST TVTAAMRILV VLLSNQSILI KFKEGLSGGG WLEQTDSVLT
NKIGTVLGFN VGRSAGGRST VREINRDACH FPGFPVLQSF LPKHTNVPAL YFLLMALFLQ
QPVSELPENL QVSVPVISSR CKQGCQFDLD SIWTFIFGVP ASSGTVVSSI HNVCTEAAFL
LLGMLRSMLN SPWQSEEEGS WLREYPVTLM QFFRYLYHNV PDLASMWMSP DFLCALAATV
FPFNIRPYSE MVGKVTDLDD EVGSPAEEFK AFAADTGMNR SQSEYCNVGT KTYLTNHPAK
KFVFDFMRVL IIDNLCLTPA SKQTPLIDLL LEASPERSTR TQQKEFQTYI LDSVMDHLLA
ADVLLGEDAS LPITSGGSYQ VLVNNVFYFT QRVVDKLWQG MFNKESKLLI DFIIQLIAQS
KRRSQGLSLD AVYHCLNRTI LYQFSRAHKT VPQQVALLDS LRVLTVNRNL ILGPGNHDQE
FISCLAHCLI NLHVGSNVDG FGLEAEARMT TWHIMIPSDI EPDGGYSQDI SEGRQLLIKA
VNRVWTELIH SKKQALEELF KVTLPVNERG HVDIAIARPL IEEAGLKCWQ NHLAHEKKCI
SRGEALAPTT QSKLSRVSSG FGLSKLTGSR RNRKESGLNK HSLSTQEISQ WMFTHIAVVR
DLVDTQYKEY QERQQNALKY VTEEWCQIEY ELLRERGLWG PPIGSHLDKW MLEMTEGPCR
MRKKMVRNDM FYNHYPYVPE TEQETNVASE VPSKQPETPD DIIPQKKPAR YRRAVSYDSK
EYYMRLASGN PAIVQDAIVE SSEGEATQQE PEHGEDTIAK VKGLVKPPLK RSRSAPDGGD
EESQEQLQDQ IAEGSSIEEE EKTDNATLLR LLEEGEKIQH MYRCARVQGL DTSEGLLLFG
KEHFYVIDGF TMTATREIRD IETLPPNMHE PIIPRGARQG PSQLKRTCSI FAYEDIKEVH
KRRYLLQPIA VEVFSGDGRN YLLAFQKGIR NKVYQRFLAV VPSLTDSSES VSGQRPNTSV
EQGSGLLSTL VGEKSVTQRW ERGEISNFQY LMHLNTLAGR SYNDLMQYPV FPWILADYDS
EEVDLTNPKT FRNLAKPMGA QTDERLAQYK KRYKDWEDPN GETPAYHYGT HYSSAMIVAS
YLVRMEPFTQ IFLRLQGGHF DLADRMFHSV REAWYSASKH NMADVKELIP EFFYLPEFLF
NSNNFDLGCK QNGTKLGDVI LPPWAKGDPR EFIRVHREAL ECDYVSAHLH EWIDLIFGYK
QQGPAAVEAV NVFHHLFYEG QVDIYNINDP LKETATIGFI NNFGQIPKQL FKKPHPPKRV
RSRLNGDSTG TSAPPGSTSD KIFFHHLDNL RPSLTPVKEL KEPVGQIVCT DKGILAVEQN
KVLIPPTWNK TFAWGYADLS CRLGTYESDK VVTVYECLSE WGQILCAICP NPKLVITGGT
STVVCVWEMG TSKEKAKTLT LKQALLGHTD TVTCATASLA YHIIVSGSRD RTCIIWDLNK
LSFLTQLRGH RAPVSALCIN ELTGDIVSCA GTYIHVWSIN GNPIVSVNTF TGRSQQIVCC
CVSEMNEWDT QNVIVTGHSD GVVRFWRMEF LQVPETPAPE PVEVLEMQED CPEAQIGQEA
QDEDSSDSEA DEQSASQDPK DTPSQPSSTS HRPRAASCRA TAVWCTDSGS DDSRRWSDQL
SLDEKDGFIF VNYSEGQARA HLQGPLNHPH SNPIEVRNYS RLKPGYRWER QLVFRSKLTM
HTAFDRKDNA HPAEITALGV SKDHSRILVG DSRGRVFSWS VSDQPGRSAA DHWVKDEGGD
SCSGCSVRFS LTERRHHCRN CGQLFCQKCS RFQSEIKRLK ISSPVRVCQN CYYNLQHERG
SEDGPRNC
//
