ID A0A6J2QXW6_COTGO Unreviewed; 574 AA.
AC A0A6J2QXW6;
DT 07-OCT-2020, integrated into UniProtKB/TrEMBL.
DT 07-OCT-2020, sequence version 1.
DT 28-JAN-2026, entry version 23.
DE SubName: Full=LOW QUALITY PROTEIN: suppressor of cytokine signaling 9 {ECO:0000313|RefSeq:XP_029302052.1};
GN Name=socs9 {ECO:0000313|RefSeq:XP_029302052.1};
OS Cottoperca gobio (Frogmouth) (Aphritis gobio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Notothenioidei; Bovichtidae; Cottoperca.
OX NCBI_TaxID=56716 {ECO:0000313|Proteomes:UP000504630, ECO:0000313|RefSeq:XP_029302052.1};
RN [1] {ECO:0000313|RefSeq:XP_029302052.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (AUG-2025) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR RefSeq; XP_029302052.1; XM_029446192.1.
DR GeneID; 115017594; -.
DR KEGG; cgob:115017594; -.
DR CTD; 100003691; -.
DR InParanoid; A0A6J2QXW6; -.
DR OrthoDB; 8820570at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000504630; Chromosome 13.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF18; SUPPRESSOR OF CYTOKINE SIGNALING 9 ISOFORM X1; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000504630};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 422..517
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 512..561
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 1..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 115..134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 146..165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..18
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..35
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..47
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 574 AA; 62997 MW; 1C8EA71E3AC303CB CRC64;
MSLPKESGNR GKGRERGARP KVRQSRSEER RDAGSVRKGG KGKKKGLSTH EPAAERPVSD
GFEYGELLSD IETRDRSSSS SLKESCKWQG LEAAASLLGQ ERVTARPVLG TVSSATEMPG
ECEGRGSSGS RTPWQKIQDA MGQCFPIKTH SPAAPAPSPQ ALSSSAASAS SRRLIHLSEL
MLDDCPFPVG SELAQKWYLI KQHTGPXITQ PPVLDPAVVC SAPTLAMAAV VEDVDDRLRE
RRRISIEQGV EPPPNAEIHT FEVTAQINPL YKHGPKLAHG MNELAGADRA SVHQQQQLLL
QRQQQHQLLL QSCLDTLDEV VASASASAST SASASASASA SASASASASA SASTSASASV
HTCDTIPNPL VDQEVTATNV PSKAILPPPK DHKSHDGYRI HTQIDYIHCL VPDLLPITNL
PCYWGVMDRY EAETLLEGKP EGTFLLRDSA QEEYLFSVSF RRYGRSLHAR IEQWNHNFSF
DVHDPNVFHA PTVTGLLEHY KDPNSCMFFE PLLSNPIHRI QPFTLQQICR AVTSSCTTYD
GINMLPIPTA LKKHLKEYHY KQRVRVRPMD TWWE
//
