ID A0A6J2R4U7_COTGO Unreviewed; 563 AA.
AC A0A6J2R4U7;
DT 07-OCT-2020, integrated into UniProtKB/TrEMBL.
DT 07-OCT-2020, sequence version 1.
DT 28-JAN-2026, entry version 23.
DE SubName: Full=Suppressor of cytokine signaling 5b {ECO:0000313|RefSeq:XP_029305284.1};
GN Name=socs5b {ECO:0000313|RefSeq:XP_029305284.1};
OS Cottoperca gobio (Frogmouth) (Aphritis gobio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Notothenioidei; Bovichtidae; Cottoperca.
OX NCBI_TaxID=56716 {ECO:0000313|Proteomes:UP000504630, ECO:0000313|RefSeq:XP_029305284.1};
RN [1] {ECO:0000313|RefSeq:XP_029305284.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (AUG-2025) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR RefSeq; XP_029305284.1; XM_029449424.1.
DR AlphaFoldDB; A0A6J2R4U7; -.
DR GeneID; 115019807; -.
DR KEGG; cgob:115019807; -.
DR CTD; 559639; -.
DR InParanoid; A0A6J2R4U7; -.
DR OrthoDB; 8820570at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000504630; Chromosome 15.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF15; SUPPRESSOR OF CYTOKINE SIGNALING 5; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000504630};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 407..502
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 497..546
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 93..172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 362..381
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 157..166
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 563 AA; 62189 MW; BB95C9EEFAAC270C CRC64;
MKKVGNMWSN LKSKCQTLFQ NNSSGPSESR VEADAVHCVV DLGQGCSSGE AQASGASSPS
RSLLPVPMVT IGRRHHNCVS DIPQIVEITI DKDTEDVRGG SGDAPMARRD SYSRHAPWGG
KKKHSCSTKT QSSLEADRRS GRLRGSGNRR DRRYGVSSIQ EMSDSVSGGR GLSARSIRQR
LSDTVGLCLP LPARRRSRST KNPVTSKRKI HLTELMLETC PFPPGSDLAH KWHLIKQHTA
PVSPHSSTAL LDAFDPAHPS PEDEEERLRE RRRLSIEEGV DPPPNAQIHT LEASVPGSSL
YKLGPKIAPC IGEASGEGRA SVASSSVSAG SSGACGQVLG AAASAQDCDS EEDSTTLCLQ
ARRPKQRHAS GDGHLSRQQP GPWKVHTQID YIHCLVPDLM QITALPCYWG VMDRYEAEAL
LDGRPEGTFL LRDSAQEDYL FSVSFRRYNR SLHARIEQWN HNFSFDAHDP CVFHSSTVTG
LLEHYKDPSA CMFFEPLLTA PLHRTFPFGL QHLARAAICR WTTYDGIGSL PLPPALQDFL
KEYHYKQKVR VRWLEREPPL KVK
//
