ID A0A6J2TUX6_DROLE Unreviewed; 392 AA.
AC A0A6J2TUX6;
DT 07-OCT-2020, integrated into UniProtKB/TrEMBL.
DT 07-OCT-2020, sequence version 1.
DT 28-JAN-2026, entry version 22.
DE RecName: Full=Proteasomal ubiquitin receptor ADRM1 homolog {ECO:0000256|ARBA:ARBA00070663};
GN Name=LOC115627216 {ECO:0000313|RefSeq:XP_030378707.1};
OS Drosophila lebanonensis (Fruit fly) (Scaptodrosophila lebanonensis).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Scaptodrosophila.
OX NCBI_TaxID=7225 {ECO:0000313|Proteomes:UP000504634, ECO:0000313|RefSeq:XP_030378707.1};
RN [1] {ECO:0000313|RefSeq:XP_030378707.1}
RP IDENTIFICATION.
RC STRAIN=11010-0011.00 {ECO:0000313|RefSeq:XP_030378707.1};
RC TISSUE=Whole body {ECO:0000313|RefSeq:XP_030378707.1};
RG RefSeq;
RL Submitted (AUG-2025) to UniProtKB.
CC -!- FUNCTION: May function as a proteasomal ubiquitin receptor. May promote
CC the deubiquitinating activity associated with the 26S proteasome.
CC {ECO:0000256|ARBA:ARBA00054744}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the ADRM1 family.
CC {ECO:0000256|ARBA:ARBA00009216}.
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DR RefSeq; XP_030378707.1; XM_030522847.1.
DR AlphaFoldDB; A0A6J2TUX6; -.
DR GeneID; 115627216; -.
DR CTD; 36545; -.
DR Proteomes; UP000504634; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0008541; C:proteasome regulatory particle, lid subcomplex; IEA:TreeGrafter.
DR GO; GO:0061133; F:endopeptidase activator activity; IEA:TreeGrafter.
DR GO; GO:0070628; F:proteasome binding; IEA:TreeGrafter.
DR CDD; cd13314; PH_Rpn13; 1.
DR FunFam; 2.30.29.70:FF:000001; Proteasomal ubiquitin receptor ADRM1; 1.
DR FunFam; 1.10.2020.20:FF:000003; Proteasomal ubiquitin receptor ADRM1 homolog; 1.
DR Gene3D; 1.10.2020.20; -; 1.
DR Gene3D; 2.30.29.70; Proteasomal ubiquitin receptor Rpn13/ADRM1; 1.
DR InterPro; IPR044867; DEUBAD_dom.
DR InterPro; IPR006773; Rpn13/ADRM1.
DR InterPro; IPR044868; Rpn13/ADRM1_Pru.
DR InterPro; IPR038633; Rpn13/ADRM1_Pru_sf.
DR InterPro; IPR032368; RPN13_DEUBAD.
DR InterPro; IPR038108; RPN13_DEUBAD_sf.
DR PANTHER; PTHR12225; ADHESION REGULATING MOLECULE 1 110 KDA CELL MEMBRANE GLYCOPROTEIN; 1.
DR PANTHER; PTHR12225:SF0; PROTEASOMAL UBIQUITIN RECEPTOR ADRM1; 1.
DR Pfam; PF04683; Rpn13_ADRM1_Pru; 1.
DR Pfam; PF16550; RPN13_C; 1.
DR PROSITE; PS51916; DEUBAD; 1.
DR PROSITE; PS51917; PRU; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Proteasome {ECO:0000256|ARBA:ARBA00022942};
KW Receptor {ECO:0000313|RefSeq:XP_030378707.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000504634}.
FT DOMAIN 13..126
FT /note="Pru"
FT /evidence="ECO:0000259|PROSITE:PS51917"
FT DOMAIN 239..353
FT /note="DEUBAD"
FT /evidence="ECO:0000259|PROSITE:PS51916"
FT REGION 167..239
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 348..392
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 167..185
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 194..204
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 207..217
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 218..239
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 364..392
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 392 AA; 42773 MW; 45D50870CDE43CA1 CRC64;
MFGRQSGLGS SSGSSSNLIE FRAGRMNMVG KMVHPDTRKG LVYMTQSDDG LMHFCWKDRT
SGKVEDDLIV FPDDFEYKRV DQCKTGRVYV LKFKSSTRRM FFWMQEPKTD KDEEHCRRIN
ELLNNPPSAH QRGGGNDNNE LQYMLNNMSQ QQLMQLFGGV GQMGGLSSLL GQMNPRTPSS
RNTSSSGGGS NSSLQTPENV SVPRTPSAPK ASKSGSSRTN LIGGNNSQGD SAGSATTSDA
GRSLNIDLST ALSGTEAINQ LIADPERVKT LIVHLPESED ADEDRKQQIK DHINSPQFQQ
ALAQFSNALQ SAQLGPVVKQ FELSNEAVAA AYSGNLEDFV RALQKSLPEG TTMDADTAGT
KELPISDKKA DSEPAAKEEN IEPSEKPEEK QK
//
