ID A0A6J2U3U6_DROLE Unreviewed; 346 AA.
AC A0A6J2U3U6;
DT 07-OCT-2020, integrated into UniProtKB/TrEMBL.
DT 07-OCT-2020, sequence version 1.
DT 28-JAN-2026, entry version 23.
DE RecName: Full=Proteasomal ubiquitin receptor ADRM1 homolog {ECO:0000256|ARBA:ARBA00070663};
GN Name=LOC115629747 {ECO:0000313|RefSeq:XP_030382142.1,
GN ECO:0000313|RefSeq:XP_030382143.1};
OS Drosophila lebanonensis (Fruit fly) (Scaptodrosophila lebanonensis).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Scaptodrosophila.
OX NCBI_TaxID=7225 {ECO:0000313|Proteomes:UP000504634, ECO:0000313|RefSeq:XP_030382143.1};
RN [1] {ECO:0000313|RefSeq:XP_030382142.1, ECO:0000313|RefSeq:XP_030382143.1}
RP IDENTIFICATION.
RC STRAIN=11010-0011.00 {ECO:0000313|RefSeq:XP_030382142.1,
RC ECO:0000313|RefSeq:XP_030382143.1};
RC TISSUE=Whole body {ECO:0000313|RefSeq:XP_030382142.1,
RC ECO:0000313|RefSeq:XP_030382143.1};
RG RefSeq;
RL Submitted (APR-2025) to UniProtKB.
CC -!- FUNCTION: May function as a proteasomal ubiquitin receptor. May promote
CC the deubiquitinating activity associated with the 26S proteasome.
CC {ECO:0000256|ARBA:ARBA00054744}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the ADRM1 family.
CC {ECO:0000256|ARBA:ARBA00009216}.
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DR RefSeq; XP_030382142.1; XM_030526282.1.
DR RefSeq; XP_030382143.1; XM_030526283.1.
DR AlphaFoldDB; A0A6J2U3U6; -.
DR GeneID; 115629747; -.
DR CTD; 31433; -.
DR OrthoDB; 340431at2759; -.
DR Proteomes; UP000504634; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0008541; C:proteasome regulatory particle, lid subcomplex; IEA:TreeGrafter.
DR GO; GO:0061133; F:endopeptidase activator activity; IEA:TreeGrafter.
DR GO; GO:0070628; F:proteasome binding; IEA:TreeGrafter.
DR CDD; cd13314; PH_Rpn13; 1.
DR FunFam; 2.30.29.70:FF:000001; Proteasomal ubiquitin receptor ADRM1; 1.
DR Gene3D; 1.10.2020.20; -; 1.
DR Gene3D; 2.30.29.70; Proteasomal ubiquitin receptor Rpn13/ADRM1; 1.
DR InterPro; IPR044867; DEUBAD_dom.
DR InterPro; IPR006773; Rpn13/ADRM1.
DR InterPro; IPR044868; Rpn13/ADRM1_Pru.
DR InterPro; IPR038633; Rpn13/ADRM1_Pru_sf.
DR InterPro; IPR032368; RPN13_DEUBAD.
DR InterPro; IPR038108; RPN13_DEUBAD_sf.
DR PANTHER; PTHR12225; ADHESION REGULATING MOLECULE 1 110 KDA CELL MEMBRANE GLYCOPROTEIN; 1.
DR PANTHER; PTHR12225:SF0; PROTEASOMAL UBIQUITIN RECEPTOR ADRM1; 1.
DR Pfam; PF04683; Rpn13_ADRM1_Pru; 1.
DR Pfam; PF16550; RPN13_C; 1.
DR PROSITE; PS51916; DEUBAD; 1.
DR PROSITE; PS51917; PRU; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Proteasome {ECO:0000256|ARBA:ARBA00022942};
KW Receptor {ECO:0000313|RefSeq:XP_030382142.1,
KW ECO:0000313|RefSeq:XP_030382143.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000504634}.
FT DOMAIN 18..131
FT /note="Pru"
FT /evidence="ECO:0000259|PROSITE:PS51917"
FT DOMAIN 219..337
FT /note="DEUBAD"
FT /evidence="ECO:0000259|PROSITE:PS51916"
SQ SEQUENCE 346 AA; 38514 MW; E48AC20BA76A3814 CRC64;
MAGNMEGVLN PLLPVDTERF GILLEFKAGR MNIAGKMVEP DTRKGSVFIR RTDDNNIHFC
WRDRISGMVE LDLLVSPRML EFRRVEQCKT GRVYVLKFIQ STRRLFFWMQ EPTHDLDDAY
CARINELLAL AESNVEMPSS DAVCTAHEHL RGGSEGVPGV QQIRSFMHSF SHEQMAQLWS
SQPMTSSATS LAMPDPAAMT FIDHSEPWMT DVESQGQYQQ QPVRHGVDFC GAFRALSAPA
VASVLTIPSA RHALAKKLPV SQSANAQELA AEIEEHARSP QFYEALGQFS WAFQAGLMGP
VMEQFGLSPT AVQAAYDGDL EQFLLSFGDD DVDTVGEVEI GTEMMQ
//
