ID A0A6J2V452_CHACN Unreviewed; 609 AA.
AC A0A6J2V452;
DT 07-OCT-2020, integrated into UniProtKB/TrEMBL.
DT 07-OCT-2020, sequence version 1.
DT 18-JUN-2025, entry version 21.
DE RecName: Full=RBR-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012251};
DE EC=2.3.2.31 {ECO:0000256|ARBA:ARBA00012251};
GN Name=LOC115809511 {ECO:0000313|RefSeq:XP_030627054.1};
OS Chanos chanos (Milkfish) (Mugil chanos).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Gonorynchiformes;
OC Chanidae; Chanos.
OX NCBI_TaxID=29144 {ECO:0000313|Proteomes:UP000504632, ECO:0000313|RefSeq:XP_030627054.1};
RN [1] {ECO:0000313|RefSeq:XP_030627054.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.;
CC EC=2.3.2.31; Evidence={ECO:0000256|ARBA:ARBA00001798};
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DR RefSeq; XP_030627054.1; XM_030771194.1.
DR AlphaFoldDB; A0A6J2V452; -.
DR GeneID; 115809511; -.
DR InParanoid; A0A6J2V452; -.
DR OrthoDB; 1431934at2759; -.
DR Proteomes; UP000504632; Chromosome 4.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016567; P:protein ubiquitination; IEA:InterPro.
DR CDD; cd20338; BRcat_RBR_RNF19; 1.
DR CDD; cd20355; Rcat_RBR_RNF19; 1.
DR CDD; cd16776; RING-HC_RBR_RNF19B; 1.
DR FunFam; 1.20.120.1750:FF:000001; RBR-type E3 ubiquitin transferase; 1.
DR FunFam; 3.30.40.10:FF:000052; RBR-type E3 ubiquitin transferase; 1.
DR Gene3D; 1.20.120.1750; -; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR031127; E3_UB_ligase_RBR.
DR InterPro; IPR002867; IBR_dom.
DR InterPro; IPR044066; TRIAD_supradom.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR11685; RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING; 1.
DR Pfam; PF01485; IBR; 2.
DR SMART; SM00647; IBR; 2.
DR SUPFAM; SSF57850; RING/U-box; 3.
DR PROSITE; PS51873; TRIAD; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000504632};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT TRANSMEM 341..373
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 394..427
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 108..331
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS51873"
FT DOMAIN 112..160
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 1..87
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 474..529
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 558..609
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..39
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 59..81
FT /note="Gly residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 567..585
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 609 AA; 65929 MW; EC197B45209A9B80 CRC64;
MKRPKQQSQP LSFLSFFSRK PKTEARIDLP AETPNHDEVA ITLTPNEQEP AEQEQSPSRG
GGGCGDNGGN GVDAGVGGGG QQAAECGSSG STGVLSLSSS SQDQLLEHLV ECPLCLLSQP
RGHFPRLSSC PHRACTDCLR QYLRIEISES RVGIACPQCS ETLAPLDVRA ILDDGTLLER
FEEYQLRRFL AADPDTRWCP APDCSYAVIA YGCAECPKLS CGREGCDTEF CYLCRQLWHP
DQTCDQARRQ RARHASGTND PSLLYVFNEE AGGEVEDIKA CPRCGAYIMK TNDGSCNRMN
CTVCACQFCW LCMQEITDVH YLSPSGCTFW GKKPWSQTRK VLWQVGMLLG APVVISLIAG
IAIPVIIVGI PIYMGRKVHG RCKKNNISGS KHYLTVASGV MMSVFVSPVI AAITVGVGVP
LMLTYVYGVV PMSLCRNGWC RTQTESPDTH KIQLEDLASY LVFSHVVSEH WSIQPKPAAS
EADGQEESGR VQDMATAPST SAVQVEPEGC QDPPDNVQDN DGLPDSQSDD AGVVALSVTQ
SFASREGTNI EVRVEIEAQP WGERQPSLSS VLSSRSLSAE SLTQSLEPPS ASAQTRDGDP
LPVTETDSV
//
