ID A0A6J2YHZ9_SITOR Unreviewed; 1557 AA.
AC A0A6J2YHZ9;
DT 07-OCT-2020, integrated into UniProtKB/TrEMBL.
DT 07-OCT-2020, sequence version 1.
DT 10-JUN-2026, entry version 25.
DE SubName: Full=Rho GTPase-activating protein 100F isoform X3 {ECO:0000313|RefSeq:XP_030762749.1};
GN Name=LOC115887457 {ECO:0000313|RefSeq:XP_030762749.1};
OS Sitophilus oryzae (Rice weevil) (Curculio oryzae).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Curculionidae; Dryophthorinae; Sitophilus.
OX NCBI_TaxID=7048 {ECO:0000313|Proteomes:UP000504635, ECO:0000313|RefSeq:XP_030762749.1};
RN [1] {ECO:0000313|RefSeq:XP_030762749.1}
RP IDENTIFICATION.
RC TISSUE=Gonads {ECO:0000313|RefSeq:XP_030762749.1};
RG RefSeq;
RL Submitted (JAN-2026) to UniProtKB.
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DR RefSeq; XP_030762749.1; XM_030906889.1.
DR GeneID; 115887457; -.
DR CTD; 43758; -.
DR OrthoDB; 120383at2759; -.
DR Proteomes; UP000504635; Unplaced.
DR GO; GO:0097060; C:synaptic membrane; IEA:TreeGrafter.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0016477; P:cell migration; IEA:TreeGrafter.
DR GO; GO:0030030; P:cell projection organization; IEA:TreeGrafter.
DR GO; GO:0046578; P:regulation of Ras protein signal transduction; IEA:TreeGrafter.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00030; C2; 1.
DR CDD; cd06718; PDZ_Par6-like; 1.
DR FunFam; 2.30.42.10:FF:000163; rho GTPase-activating protein 100F isoform X1; 1.
DR FunFam; 1.10.555.10:FF:000031; rho GTPase-activating protein 100F isoform X6; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR052118; Rho-GAP_regulator.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR057459; SYDE1/2_C2.
DR PANTHER; PTHR46150; RHO GTPASE-ACTIVATING PROTEIN 100F; 1.
DR PANTHER; PTHR46150:SF3; RHO GTPASE-ACTIVATING PROTEIN 100F; 1.
DR Pfam; PF25336; C2_SYDE; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00239; C2; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468, ECO:0000256|PROSITE-
KW ProRule:PRU00172}; Reference proteome {ECO:0000313|Proteomes:UP000504635}.
FT DOMAIN 122..192
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 747..886
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 927..1144
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 25..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 202..268
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 280..338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 355..402
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 556..586
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 647..722
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1144..1338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1495..1557
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..45
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 220..236
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 246..268
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 363..377
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 660..681
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1228..1241
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1256..1272
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1290..1312
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1313..1325
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1513..1534
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1539..1550
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1557 AA; 169109 MW; 6E62EE1910BFF1F0 CRC64;
MCDKNGKGCF FTRKDNGREA LDLTASPLRA PPTAPNNRPS HPPPMVIQGD FRKVSGISTE
IFKQIEAVEN DHDASTAAAL EHVERRGEMI VRILDARHLG RSAVEQAKRF LAMQDAKHQV
QFVEIVKRPG QTLGLYIREG NGQDRPDGVF ISRIALESAV YNSGCLKVGD EILAVNLVDV
THMSLDDVVI IMSIPRRLVL ATRQRKGGKG GQGSPSVQPR AEHKPPPVVV IKRDLREDEG
DEVDAPDQHR DPMRQRHTGD GREMNESRSR LGLGLSTLDR QTDRHSQQHS QQPDSNGLDL
YYNSRPPDTS WGYQPPPPVI TEQPKSSQPH FPQYDRGYPN TLESLAEKVH SFGMGRRMSA
GGQPVPSRMS SQQSPSSHYY VQHAGTGSRR IMPRSGSDQH LPQTEYTDYT SITQAGRHSL
LRSSLKSGST LSRYNQRYVD QAAVAAQLQS KYGTTGSQYG TSTLRRNRGS LDYSSDTEAT
IGSRAGYYYY RDRPSVPAPV PHSTIPTLAR QGSMAAPGGD ITTKFNSLPR DARGASRLAM
NKRFGDRSVS GVPLLQDDAD GALSAPEMPS SIRRDRGRVP SSPSVFSSDE YRQWLSRTPS
TSAIYEQIRA SRDVLNQQRA ARFTYSAENI HDALKNMESG IYSSYGRPGT TSTLDRHFSR
SQQPSIPARS LSTQHITSAA LSSTRSPSMR RMRQLLDLDS VRSGGAPSPV PTPSGTLPRG
QRQLDINPAE FLKYKIDKPG IPGTSSITGL SQLTSGTLGS TTDEPVSGML WVHLLAGRGL
RASTGTSAAT TPVTPSGGVP TIGGSTGLRD LYCVLECDRV HKARTVVRTG DLVFDWDESF
ELDLVNNREL DLLIYSWDPQ YRHKLCYKGS VYLPTLLKSG PIHQLALKIE PRGTLYLRLR
YTDSQNLYRR RALTTLTLSR TTPLFGVDLE SVVNRENKTG GVPGGVATGL VTGSQHSIPI
IVKRCVEEVE RRGLDIIGLY RLCGSATKKR ILREAFERNS RSVDLSPDNV PDINVITGVL
KDYLRELPEP LFTKCLYQMM VDALGVCLPD DPEGNAKLMF SILDCLPRIN RATLIFLMDH
LALVVSASDR NKMNAQNLAT ALAPPLMLHS GDTMTPTSAK SHDLEYQQPI SVLRYLLQIW
PTPKHHSGRR GRLPGPRGDS RSACPAEVSG ARAAALGQSR PSAAPSPLPP RSAASAQPRG
PLPPVPSHQI LGPSSASKGP YRPLSPRVAL PVAAGPASSG PVAPPGPIKP RHVIVSSPGS
PSSSSDSQSG SDSVKHCLPS RVSSPAIRAS PSSQTMMRSS PSVTISSPGL RQSPSTTLSS
SIGSPAGPRN SPSVTSISRA SPSLFSQVSR SSSPAMQASS AGLNVTLDGA TPQVSSLSGL
QNTISNMNTT TGTMFGLYTQ PTTYASTNPF LTGAYMSYNP VESSYSDKFN TIGSTKDIKS
FFENYSSDTT KYSTKSTTGY ETQSTYTMSE NKYNTIGSKY QDQKSSYLSS ISSAGEMKYS
PNKNGERFES EQGRSQSSSG LLNVEETPTP TSSIETEDSN TREVGEKDVE GDGEQSD
//
