ID A0A6J2YJE0_SITOR Unreviewed; 1062 AA.
AC A0A6J2YJE0;
DT 07-OCT-2020, integrated into UniProtKB/TrEMBL.
DT 07-OCT-2020, sequence version 1.
DT 28-JAN-2026, entry version 27.
DE RecName: Full=phosphatidylinositol 3-kinase {ECO:0000256|ARBA:ARBA00012073};
DE EC=2.7.1.137 {ECO:0000256|ARBA:ARBA00012073};
GN Name=LOC115888539 {ECO:0000313|RefSeq:XP_030764148.1};
OS Sitophilus oryzae (Rice weevil) (Curculio oryzae).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Curculionidae; Dryophthorinae; Sitophilus.
OX NCBI_TaxID=7048 {ECO:0000313|Proteomes:UP000504635, ECO:0000313|RefSeq:XP_030764148.1};
RN [1] {ECO:0000313|RefSeq:XP_030764148.1}
RP IDENTIFICATION.
RC TISSUE=Gonads {ECO:0000313|RefSeq:XP_030764148.1};
RG RefSeq;
RL Submitted (AUG-2025) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a
CC 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP +
CC H(+); Xref=Rhea:RHEA:12709, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:57880, ChEBI:CHEBI:58088, ChEBI:CHEBI:456216;
CC EC=2.7.1.137; Evidence={ECO:0000256|ARBA:ARBA00001498};
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. {ECO:0000256|PROSITE-
CC ProRule:PRU00880}.
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DR RefSeq; XP_030764148.1; XM_030908288.1.
DR AlphaFoldDB; A0A6J2YJE0; -.
DR GeneID; 115888539; -.
DR OrthoDB; 67688at2759; -.
DR Proteomes; UP000504635; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0005886; C:plasma membrane; IEA:TreeGrafter.
DR GO; GO:0016303; F:1-phosphatidylinositol-3-kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0035005; F:1-phosphatidylinositol-4-phosphate 3-kinase activity; IEA:TreeGrafter.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0032060; P:bleb assembly; IEA:UniProtKB-ARBA.
DR GO; GO:0016477; P:cell migration; IEA:TreeGrafter.
DR GO; GO:0043491; P:phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:TreeGrafter.
DR GO; GO:0048015; P:phosphatidylinositol-mediated signaling; IEA:TreeGrafter.
DR GO; GO:0050920; P:regulation of chemotaxis; IEA:UniProtKB-ARBA.
DR CDD; cd05165; PI3Kc_I; 1.
DR FunFam; 1.10.1070.11:FF:000001; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit; 1.
DR FunFam; 3.30.1010.10:FF:000008; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 3.10.20.90; Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1; 2.
DR Gene3D; 3.30.1010.10; Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4; 1.
DR Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR015433; PI3/4_kinase.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR002420; PI3K-type_C2_dom.
DR InterPro; IPR003113; PI3K_ABD.
DR InterPro; IPR001263; PI3K_accessory_dom.
DR InterPro; IPR042236; PI3K_accessory_sf.
DR InterPro; IPR000341; PI3K_Ras-bd_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR PANTHER; PTHR10048:SF118; PI-3 KINASE; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF00792; PI3K_C2; 1.
DR Pfam; PF02192; PI3K_p85B; 1.
DR Pfam; PF00794; PI3K_rbd; 1.
DR Pfam; PF00613; PI3Ka; 1.
DR SMART; SM00142; PI3K_C2; 1.
DR SMART; SM00143; PI3K_p85B; 1.
DR SMART; SM00144; PI3K_rbd; 1.
DR SMART; SM00145; PI3Ka; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS51547; C2_PI3K; 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR PROSITE; PS51544; PI3K_ABD; 1.
DR PROSITE; PS51546; PI3K_RBD; 1.
DR PROSITE; PS51545; PIK_HELICAL; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000504635};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 19..108
FT /note="PI3K-ABD"
FT /evidence="ECO:0000259|PROSITE:PS51544"
FT DOMAIN 185..283
FT /note="PI3K-RBD"
FT /evidence="ECO:0000259|PROSITE:PS51546"
FT DOMAIN 325..492
FT /note="C2 PI3K-type"
FT /evidence="ECO:0000259|PROSITE:PS51547"
FT DOMAIN 518..695
FT /note="PIK helical"
FT /evidence="ECO:0000259|PROSITE:PS51545"
FT DOMAIN 760..1045
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
SQ SEQUENCE 1062 AA; 122817 MW; 0AD3B5D1A089605E CRC64;
MVPIPAEYMP DFWSLLSTEC PIVELTCLLP NGIIVLLKVN HNATLAEIKE DLWEEASRFP
LYGKLHDISV YTFKIINSMA EEEELNDDLR KLCDIKPTGG VLIISECRGN SVDHSVNVAI
GHLIGKGLQE FDALNSNEIN DFRFKMRKMG DEISEKRNQG TWLDKLQYQF PPRLSQSDDV
KFKGIKCICV ETKCEYEIAE FERESLQSTF KLNVLPTTKP IELMEMILSK RANLNIKNES
VTEYILKICG RDEYLVGDFS IIEFQYIQDC LLQDIIPSFL SVHINRILDN DYDYVDILEA
RKNKTVFNST NTLRKKKNIE STWNISDNYT ITLCTASKLN CDTKKSTEIG IQVGLFHGGK
PLCQPVKTEE RLVSEKCEVE FNVDLELDIE VWHIPRNAKL CFVIYESNKY FKGTKSRKPK
EVKDSQINPI AWANTTVFDF KGYLRTGAMT LYLWTYAEDI MSDDVLHPLG TVVSNPNKEY
CTALTLIFKS YGSDQNYTYP ALETVINYGN SLQEINNSIL ETLTDETKES FLRLINDMDN
FYDIYDQDRE TIWSHRKFWI KHTPELFPKL LLCIDWNKRE DVSQAIVLTR ECPKLPIEKA
LELLDYAYAD QVVRSFAVQC LQDMSDEDLL LYLLQLVQAI KHELYLDCDL VNFLIKRALD
NQKIGHYLFW HLRSEMQVAS VSVRFGLILE AYCRGSQEHI PVLQRQLKSI EKLKQCSEIV
RNRRDKEKAK AALKEYIVNN SAKDIVRSPL DPSYRCNGIK IEKCRVMDSK MKPLWIVYEN
YDRYGEDVYL IFKNGDDLRQ DMLTLQMLKI MDKLWKREGL DLRMNPYNCI SLEPRVGMIQ
VVLNAETIAN IQKEKNSFAP TASFRKGSIL AWLKDHNTTE AALNKAIKEF TLSCAGYCVA
TYVLGIGDRH SDNIMVKKTG QLFHIDFGHI LGHFKEKFGI KRERVPFVLT HDFVFVINKG
QKTQQETPTE FKEFQDNCEK AFMILRKHGN LILSLFAMMI STGLPELSSE KDLQYLRETL
VLSKTDEEAK AHFRAKFDEA LSNSWKTSLN WASHNIAKNN KG
//
