ID A0A6J3CF16_AYTFU Unreviewed; 4140 AA.
AC A0A6J3CF16;
DT 07-OCT-2020, integrated into UniProtKB/TrEMBL.
DT 07-OCT-2020, sequence version 1.
DT 28-JAN-2026, entry version 26.
DE RecName: Full=DNA-dependent protein kinase catalytic subunit {ECO:0000256|ARBA:ARBA00018077};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=PRKDC {ECO:0000313|RefSeq:XP_032037015.1};
OS Aythya fuligula (Tufted duck) (Anas fuligula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Aythyinae; Aythya.
OX NCBI_TaxID=219594 {ECO:0000313|Proteomes:UP000504639, ECO:0000313|RefSeq:XP_032037015.1};
RN [1] {ECO:0000313|RefSeq:XP_032037015.1}
RP IDENTIFICATION.
RC TISSUE=Lung {ECO:0000313|RefSeq:XP_032037015.1};
RG RefSeq;
RL Submitted (AUG-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family.
CC {ECO:0000256|ARBA:ARBA00011031}.
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DR RefSeq; XP_032037015.1; XM_032181124.1.
DR FunCoup; A0A6J3CF16; 697.
DR GeneID; 116485633; -.
DR KEGG; aful:116485633; -.
DR CTD; 5591; -.
DR InParanoid; A0A6J3CF16; -.
DR Proteomes; UP000504639; Chromosome 2.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004677; F:DNA-dependent protein kinase activity; IEA:InterPro.
DR GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:InterPro.
DR GO; GO:0033152; P:immunoglobulin V(D)J recombination; IEA:TreeGrafter.
DR GO; GO:0008630; P:intrinsic apoptotic signaling pathway in response to DNA damage; IEA:TreeGrafter.
DR GO; GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW.
DR GO; GO:0000723; P:telomere maintenance; IEA:TreeGrafter.
DR CDD; cd05172; PIKKc_DNA-PK; 1.
DR FunFam; 1.10.1070.11:FF:000018; DNA-dependent protein kinase catalytic subunit; 1.
DR FunFam; 3.30.1010.10:FF:000013; Protein kinase, DNA-activated, catalytic subunit; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 3.30.1010.10; Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR050517; DDR_Repair_Kinase.
DR InterPro; IPR037706; DNA-PK_dom.
DR InterPro; IPR046804; DNA-PKcs_N.
DR InterPro; IPR046803; DNAPKcs_CC1-2.
DR InterPro; IPR012582; DNAPKcs_CC3.
DR InterPro; IPR045581; DNAPKcs_CC5.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF68; DNA-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT; 1.
DR Pfam; PF20500; DNA-PKcs_N; 1.
DR Pfam; PF20502; DNAPKcs_CC1-2; 1.
DR Pfam; PF08163; DNAPKcs_CC3; 1.
DR Pfam; PF19704; DNAPKcs_CC5; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM01344; NUC194; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 3.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|RefSeq:XP_032037015.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000504639};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ribosome biogenesis {ECO:0000256|ARBA:ARBA00022517};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 2919..3551
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 3734..4065
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 4108..4140
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT COILED 3601..3628
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4140 AA; 473394 MW; 1C957E717BD02D2D CRC64;
MAGPVPGALQ QLQACLRHPD PPGAALRACG LLRAMAEACL ACPPGAAQAL HASLVLSAEQ
GLPAFVCRSL GAEEFRECRE EALRFLRVFM EKVGGGAHPY ARGIKQACLS VYTKDRAAKC
KIPALELLIK LLQNLRNSHL MEEMKVGEIF NKFYGELAVR SRVSDTVLEK IYELLGVLGE
VQPTDMINNS EKLFRAYLGE LKTQMTSATR VPKLTVVAGC LRGLTALMYN FTKSVDEDPE
TSKEIFDYAV KAIRPQVDQK RYAVHLAGLQ LFSFHAAQFG TLLLDNYVIL FETMCKWCGH
PNQEMKKAAN SALDSFLKQM SIMVAKDAEL HKSKLKFFME QFYGIIRRMD SSNKELSIAI
RGYGLFAAPC KAIHSKDVDE MYVELLQRCK QMYLTEAETI DDNLYQLPSF LQSIASVIFH
LDTIPEVYTP VLEHLVVLQI NNFPQYSEKM QLICCRSIIK VFLALSGKGP VLWSFIGTVV
HQGLIRVFSK PMTFSKEFFG KETSESEDSP EAGETGTGKW KVPTYKDYLY LFRSLLNCDT
IKESVFEDEN FLTGNSPLKS LSRLLYDEFI KSILKIIEKL DLTVQKLNVH EQDENEIDSA
LIGPTSDPVS NLQPTKPTDF IAFINLVEFC REILPDKHVE YFSPWVYSFG YELIIHSTRL
PLISGFYKLL SVTMKIAKRI KYFEGVSPKS LRKSTEDPEK SSCFALFVKF GKEVTAKMKQ
YKDELLASCL NFLLCLPHDI IMLDIKAYIP ALQNAFKLGL SCIPLADLGL DALEDWSTHI
PKHIMQPYYK DVLPLLDGYL KNSTPTAEPQ DNWEVKKLSR AAQKGLNKVV IQRLRKAKTS
SLDDNPSLEA VRTRVVRLLG SLGGQINHNL ITATSAEEMM KKCVSWDTER HLSFAVPFAD
MKPVIYLDLF LPRVTDLALS ASDRQTKVAA CELLHSIVAY MLGKSSQMPE RREGPPPMYL
LYKRLFPVLL RLACDVDQVT RQLYEPLVMQ LIHWFTNNKK FESQDTVAFL EAILGGIVDP
VDSTLRDFCG QCVREFLKWS IKQTTPRQQE RSPANTKSLF KRLYSLALHP SAFKRLGAAL
AFNSIYREFR EENSLVEQFV FEALVVFLES LALSHTDEKS LGTAQQCCDT IHHLKRIIMH
KAPSLNKEGK RRVPRGFPAS KSVCLEDIVM WLLVQCGRPQ TECRHKAMEL FYEFVPLLPG
NNSPSSWLDD VLKKQDVSFL INKFEGGGSY AKSPSGILSQ PTLRCMQEPF SLQTVMRWMD
MFLAALDCYN TFFELQMIKP HKILGIKKKG VRSSFLKAVQ FFLETIALHD IHATEQCFDS
RSKGNVFSPQ EREMYNYSKC TIIVRIMKFV TLILETCQQD FWELLEKELL NESFVELLVM
TVCDPSHIGF NTADVQVMKN LPDISVRLLK ALMKSPYKES LKVCLKKRIT PQSFEDLCSV
DLFNSDARFD QVRFSALLCA CKQLQKSGLL HSVLYDQDER PHSSIGSMLL SVVYKGIAPG
GQRISLPSLD ISSKRLADRL LQLSFAIDDQ CEELLSLLLN TVVLSVPLSG ALQSNLINFS
HGQYFYSLFS DTINQQLLKH LDVIILQLME SSASNPQMVG SILNGMLDQS FRERTIRKQQ
GVKLVTAVLR NWKKLDSWWA KGSTPESKMA VLTLLAKVLQ IDSSVSFNTN HEAFTAVFDT
YTSLLTDQNL SLNLKGQAVI ILPFFTNLTG EKLNDLKDAL DQLVAFNFPM SSDEFPKGTL
KHNNYVDCTK KFLDALELSQ SPMLLQLMTE ILCRDQRHFM EDLFQASFKR ISRRSSTDKQ
VILLDTVHKM FQREDHLSNT TRQAFVDRSL LTLLSHCSLD ALREFFSNII VQAMDALNSR
FTKSNECIFD TQVTKKMGYY KLLEVMYVRL SKEDVHSKDS KINQAYRGSI SVEGNELTKA
LIKSCYDAFT ENMAGESQLL EKRRQYHCAA YNCAIAVISC VFTETKFYQG FLFTEKAEKN
LLIFENLIDL KRQYTFPVEI EVPLERKKRY IAIRKEAREA GNGDPDEPKY LASASYMMDS
SLSEEMSQFD FSTGVQGFSY SSQDVAASSA RFRRKETSEY MVLKDEMELE MDELNQHECM
ASMTTLIKHM QRNQITPKVE EGTVPVDLPL WMKFLHGKLG NPSVPLNIRL FIAKLIVNTE
DVFRPYAKQW LGPLLQLVVS GNNGGEGIHY MVVEITVTVL SWTSVTTPKG NVKDEILANR
LLEFLMKNAF HPKRAVFRHN LEIIKTVIEC WKNCLSIPYN LIFEKFSTGD PDTKDNSVGI
QLLGIVLANN LAPFDPKCEI DRGRYFQALT SNMGLLRYKE VYAAAAEVLG LALQYIAERE
NILEDQVYDC VVKQLKHHQN TQQDKFIICL NKVVKNFPPL ADRFMNAVFF LIPKLHGVMK
TYCLEVIMCR AEEIPDLYLE LKSKDFMQIM NHRDDERQRV CLDIVYKMLS KLKPPELKEF
LPGVTGFISH PSVLCRRSMY DILMWIYDNY SDPESQADGD SQEVLKLAKE ILLQGLIDEN
AELQLIVRNF WSDETRLPAN ILDRMLALLS SLYSTKIETQ YLSLITNFLL EMTSKSPDYS
RKMFEHPLSE CKFQDFVIDS SWRYRSTMLT PMFVETQVSQ STNKNLSQER SPSFSGSVGG
QVRATQRQYE FTPTQNVSGR SSFNWLTGNS IDTLAEYTVP SSSESLSSSM LLVSKRSEKF
KQAAFKPVGP DFGKKRLALP EDEVDSKTKG IEERAEILRL RRRFLKDREK VSLIYARKGV
AEQKREQEIK SELKMKYDAQ VTLYRSYRVG DLPDIQIEYC SLIAPLQGLA QKDPTFAKQL
FSSLFGGIFH EVEKSKTPSE KKVIIQKLLK DFNHFLSMSL SYFPPFIACI QEMSYEHREL
LELDSANVST SCLASLQQPV GILLLEHALM ALCPAEEPPS KRMRGRTELP PDVIRWIELA
KLYRSLGDYD VLRGIFSGKI GTKEITQKAL LAEARSDYAE AAKYYDEALS QEVWEDGEPT
EAEKDFWELA SLECYDHLTE WKSLEYCATV NIDSSKPPDL SKTWNDPFYQ ETYLPYIIRS
KLKLLLNGEN DQTLLTFIDE AMKTEQKKAV IEMYYSQELS LLYILQDDFD RAKYYISNGM
QIFMQSYSNI DSLLYQSRMT KLQSVQALTE IQDFINFMTK RSNLASQASL KRLLRTWTSR
YPDAKMDPMN IWDDIITNRC FFLDKLQEKL LSDQANDSME VDEECGIGEP MEVDQQSEDI
PSMIRSCKFN MKMKMIESAR KQNSFSVARK LLKDLRREAK TREDWLVRWN CSYCRFTHSF
SRNQSHPERV LSVLKTTSLL EDTNSDYLSK NVMAFRNQNL LLGTTYHIMA NALSQDPGCL
EQIEEEKAVK ISVLLGESLD SPEKVLAGLN KRAFQYFSSA ARKSEEEVQS HAMEHVDVMG
VIDAYMTLVG FCDHHLRKEE EGLLEINTAE LQLFPAIVVE KMIKALKLNS REARLRFPRL
LQLVERYPAE TLGLVTRELS SVPCWQFIGW ISQMMALLDK DEAIAVQHTV EEIANTYPQA
IIYPFMISSE SFCFKDTANG CKNKEFVERI KSKLDRGGVV QDFVCSLEQL SNPVMLFKDW
VEDVRNELLK TERNKNKLKE MYEEMYKNLG DLEAPGLGLM RKRFIQAFGK DFNSHFGKGG
SKLLDMKAKD FNGIVTSLLA KMNEKHREPG NLKECSPWMS DFKAEFLRNE LEVPGQYDGK
GKPLPEYHVK ISGFDERISV MESLRKPKRI IIRGSDEQEY PFLVKGGEDL RQDQRIEQLF
DVMNIILSQD AACSQRNMQL KTYQVIPMTT RLGLIKWLEN TCTLKEFLRN SMSEEEQFNY
NSQKGPRAAY IEWLAKMSGK AQGMSRYHYM YKNASRTETV ISFKSRESSV PEDLLRRAFV
KMSTSPEAFL SLRSHFASSH ALMCISHWIL GIGDRHLSNF MINKETGGMV GIDFGHAFGS
ATQILPVPEL MPFRLTRQFV NLMMPVKEWG LIYSVMVHAL RAYRADPDPL INTMDVFVKE
PSLDWKNFEQ RQLKKGGTWI KEINTSQVNW YPLQKVSYVK RKLTGCNPAR ITCDELRLGY
EKSSFYNDCA AVARGNTDHN IRAKEPEDGL SEETQVRCLI DQATDPNVLG RVWEGWEPWM
//
