ID A0A6J3E8S8_AYTFU Unreviewed; 2590 AA.
AC A0A6J3E8S8;
DT 07-OCT-2020, integrated into UniProtKB/TrEMBL.
DT 07-OCT-2020, sequence version 1.
DT 28-JAN-2026, entry version 24.
DE SubName: Full=Fibrillin-3 isoform X2 {ECO:0000313|RefSeq:XP_032059549.1};
GN Name=FBN3 {ECO:0000313|RefSeq:XP_032059549.1};
OS Aythya fuligula (Tufted duck) (Anas fuligula).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Aythyinae; Aythya.
OX NCBI_TaxID=219594 {ECO:0000313|Proteomes:UP000504639, ECO:0000313|RefSeq:XP_032059549.1};
RN [1] {ECO:0000313|RefSeq:XP_032059549.1}
RP IDENTIFICATION.
RC TISSUE=Lung {ECO:0000313|RefSeq:XP_032059549.1};
RG RefSeq;
RL Submitted (AUG-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- SIMILARITY: Belongs to the fibrillin family.
CC {ECO:0000256|ARBA:ARBA00008972}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; XP_032059549.1; XM_032203658.1.
DR GeneID; 116499057; -.
DR CTD; 84467; -.
DR Proteomes; UP000504639; Chromosome 26.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-ARBA.
DR GO; GO:0001527; C:microfibril; IEA:UniProtKB-ARBA.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0009887; P:animal organ morphogenesis; IEA:UniProtKB-ARBA.
DR GO; GO:0048598; P:embryonic morphogenesis; IEA:UniProtKB-ARBA.
DR GO; GO:0048731; P:system development; IEA:UniProtKB-ARBA.
DR CDD; cd00054; EGF_CA; 28.
DR FunFam; 2.10.25.10:FF:000023; Fibrillin 2; 2.
DR FunFam; 2.10.25.10:FF:000038; Fibrillin 2; 2.
DR FunFam; 2.10.25.10:FF:000049; Fibrillin 2; 1.
DR FunFam; 2.10.25.10:FF:000058; Fibrillin 2; 1.
DR FunFam; 2.10.25.10:FF:000071; Fibrillin 2; 1.
DR FunFam; 2.10.25.10:FF:000086; Fibrillin 2; 1.
DR FunFam; 2.10.25.10:FF:000087; Fibrillin 2; 1.
DR FunFam; 2.10.25.10:FF:000107; Fibrillin 2; 1.
DR FunFam; 2.10.25.10:FF:000131; Fibrillin 2; 1.
DR FunFam; 2.10.25.10:FF:000141; Fibrillin 2; 1.
DR FunFam; 2.10.25.10:FF:000149; Fibrillin 2; 1.
DR FunFam; 2.10.25.10:FF:000159; Fibrillin 2; 1.
DR FunFam; 2.10.25.10:FF:000171; Fibrillin 2; 1.
DR FunFam; 2.10.25.10:FF:000196; Fibrillin 2; 1.
DR FunFam; 2.10.25.10:FF:000223; Fibrillin 2; 1.
DR FunFam; 3.90.290.10:FF:000005; Fibrillin 2; 1.
DR FunFam; 3.90.290.10:FF:000006; Fibrillin 2; 1.
DR FunFam; 3.90.290.10:FF:000007; Fibrillin 2; 1.
DR FunFam; 3.90.290.10:FF:000009; Fibrillin 2; 1.
DR FunFam; 3.90.290.10:FF:000010; Fibrillin 2; 1.
DR FunFam; 3.90.290.10:FF:000011; Fibrillin 2; 1.
DR FunFam; 3.90.290.10:FF:000014; Fibrillin 2; 1.
DR FunFam; 2.10.25.10:FF:000133; Fibrillin 3; 1.
DR FunFam; 3.90.290.10:FF:000008; Fibrillin 3; 1.
DR FunFam; 2.10.25.10:FF:000003; fibrillin-1 isoform X1; 16.
DR FunFam; 2.10.25.10:FF:000002; Latent-transforming growth factor beta-binding protein 3; 2.
DR FunFam; 2.10.25.10:FF:000014; Latent-transforming growth factor beta-binding protein 3; 1.
DR FunFam; 2.10.25.10:FF:000010; Pro-epidermal growth factor; 2.
DR FunFam; 2.10.25.10:FF:000096; Putative fibrillin 2; 1.
DR FunFam; 2.10.25.10:FF:000008; Signal peptide, CUB domain, EGF-like 2; 1.
DR Gene3D; 2.10.25.10; Laminin; 43.
DR Gene3D; 3.90.290.10; TGF-beta binding (TB) domain; 8.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR000742; EGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR024731; NELL2-like_EGF.
DR InterPro; IPR049883; NOTCH1_EGF-like.
DR InterPro; IPR017878; TB_dom.
DR InterPro; IPR036773; TB_dom_sf.
DR InterPro; IPR052080; vWF_C/EGF_Fibrillin.
DR PANTHER; PTHR47333:SF5; FIBRILLIN-3; 1.
DR PANTHER; PTHR47333; VON WILLEBRAND FACTOR C AND EGF DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF07645; EGF_CA; 38.
DR Pfam; PF14670; FXa_inhibition; 1.
DR Pfam; PF12661; hEGF; 1.
DR Pfam; PF00683; TB; 8.
DR PIRSF; PIRSF036312; Fibrillin; 1.
DR SMART; SM00181; EGF; 43.
DR SMART; SM00179; EGF_CA; 43.
DR SUPFAM; SSF57196; EGF/Laminin; 12.
DR SUPFAM; SSF57184; Growth factor receptor domain; 9.
DR SUPFAM; SSF57581; TB module/8-cys domain; 8.
DR PROSITE; PS00010; ASX_HYDROXYL; 40.
DR PROSITE; PS01186; EGF_2; 25.
DR PROSITE; PS50026; EGF_3; 38.
DR PROSITE; PS01187; EGF_CA; 15.
DR PROSITE; PS51364; TB; 8.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000504639};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 7..48
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 53..106
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 173..211
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 214..253
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 254..295
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 296..336
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 337..377
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 383..435
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 447..488
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 489..530
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 531..570
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 575..614
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 634..675
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 680..731
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 752..793
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 794..836
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 837..873
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 879..920
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 962..1003
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1004..1041
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1046..1086
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1087..1125
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1128..1169
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1170..1206
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1211..1251
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1256..1312
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1329..1370
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1371..1408
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1417..1469
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1487..1528
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1529..1567
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1613..1648
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1652..1694
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1695..1734
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1735..1776
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1781..1834
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1850..1891
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1892..1931
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1973..2016
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2017..2058
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2063..2116
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 2128..2165
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2170..2210
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2211..2247
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2250..2292
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2333..2369
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 218..228
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 535..545
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1617..1627
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2590 AA; 279415 MW; 449378BA1BF9181E CRC64;
MSKEDTDVDE CGAVSSVCDG GECTNTAGSY VCTCPRGFMT SPDGSRCIDQ RIGTCFSALI
GGRCAGDLPG QYTKMQCCCD SGRCWAIGQT PEMCPVRGSD EYRRLCIEGL PVVPGFPGSF
PGIPGFGPNG VGPGLNGPGG IGPNGANGQG GIPGLPGMGP GSSSIGTATL NQTIDICKHF
TNLCLNGRCI PTPSSYRCEC NMGYKQDVRG ECIDVDECSS SPCVHGDCVN TPGSYHCKCH
EGFQSTPTKQ ACIDIDECIM NGVMCRNGRC VNTDGSFQCI CNAGFEITPD GKNCVDHDEC
ATTNMCLNGM CINEDGSFKC ICKPGFVLAP NGRYCVDIDE CETPGICMNG WCINTEGSFR
CECLGGLAIG VDGRVCVDTH MRSTCYGGIK KGTCARPFPG AVTKSECCCA NPDHGFGEPC
QPCPAKNSAE FQALCSSGIG ITADGRDINE CALNPDICPN GMCENLRGSY RCICNLGYES
DPTGKNCVDV DECTVNRLLC DNGLCRNTPG SYTCTCPKGF VFRTETDTCE DINECTSNPC
VNGVCRNNAG SFACECSPGS KLDPSGTICV DSMKGTCWLN IQDGRCEVNI NGATLKSECC
ATLGAAWGSP CERCEIDTAC PRGYARMKGV TCEDVNECDV FPGVCPNGRC VNTAGSFRCE
CPEGLTLDGT ARTCVDVRVE QCYMKWDEDE CTEPLPGKYR IDMCCCSVGS AWGIDCEECP
KVGSNEYKAI CPRGPGFANR GDVLSGRPFY KDVNECKVFS GLCTHGTCRN TIGSFRCLCG
SGFALDAEER NCTDIDECRI SPDLCGHGTC VNTPGSFECE CFEGYESGFM MMKNCMDINE
CEQDPLLCRG GICMNTDGSF ECICPPGHEL TSEGNICVDI NECSLSDNLC RNGRCVNIIG
TYQCACDSGF QATPDRQGCV DIDECTITNG GCDTHCSNSE GSYECSCSEG YALMPDKRSC
ADIDECEDNP DICDGGQCTN IPGEYRCLCF DGFMASLDMK TCIDVNECDL NPNICLHGEC
ENTKGSFICH CQLGYFVKKG TTGCTDIDEC EIGAHNCDMH ASCINVPGSF KCKCRTGWLG
DGLKCNDLDE CATEEHKCNL NANCINTPGS YRCACREGFN GDGFSCTDVD ECADNVNLCE
NGQCLNAPGG YRCECEMGFN PTEDSKACQD IDECTFQNIC VFGTCQNLPG MFRCACDDGY
ELDRSGGNCT DINECADPVN CINGLCVNTP GSYLCNCPQD FELNPTGVGC VDTRVGNCFL
DTQDRGDGGI SCSAEIGVGV TRASCCCSLG RAWGNPCELC PPANTTEYKT LCPGGEGFRP
NPITVILEDI DECQELPGLC QGGNCVNTFG SFQCECPLGY YLNEDTRICE DIDECSAHIG
ICGPGTCYNT LGNYTCVCPP EYMQVNGGNN CMDMRKSVCY RNYNDTCENE LSFNMTKKMC
CCSYNIGKAW NKPCEPCPTP ASSEYQILCG NQAPGFIIDI HTGKPIDIDE CSEIPAICTN
GVCINQIGSF RCECPIGFSY NNILLICEDI DECSSGENLC QRNADCINIP GSYRCECSTG
YKLSPSGACV GRNECQEIPN VCSHGDCVDT EGSYICICHN GFKATGEQTM CMDIDECDRQ
PCGNGTCKNT VGSYNCLCFP GFELTHNNDC MDIDECSSLV GQVCRNGQCI NSIGSFQCLC
QEGYDRTPDG KNCVDINECV SLPGTCSPGT CQNLEGSFRC ICPPGYEVQN DNCIDINECE
EEPNICLFGT CTNTPGSFQC VCPPGFVLSD NGRRCFDTRQ SFCFTRFDNG KCSVPKAFNT
TKARCCCSKM PGEGWGDPCE LCPQEGNVAF QELCPYGHGA IPGPGDTRED VNECSENLGV
CINGACINTD GSFRCECPFG YNLDYTGVNC VDTDECSIGN PCGNGTCTNV VGGFECACDE
GFEPGPMMTC EDINECALNP LLCAFRCINT FGSYECTCPS GYALREDRRM CRDLDECVEG
LHDCESRGML CKNLIGTFMC ICPPGMQRRP DGDGCTDENE CRTKPGICPN GRCINTVGSY
RCDCNEGFEV SPSGTECIDT RQGFCFTEVL QTMCQMSSTN RNLVTKSECC CNSGRSWGPQ
CELCPLPGTA QYKKMCPHGP GYSTDGRDID ECKVLPNLCK NGQCINSIGS FRCHCKLGYT
ADITGTACVD LDECNQSPKP CNFICKNTEG SYQCSCPRGY ILQEDGKICK DLDECSTKQH
NCQFLCVNII GGFNCKCPPG FTQHHSSCID NNECTAQPSL CGAKGQCLNT PGSYNCECQK
GFSLDSSGVN CEDVDECDGN HRCQHGCQNV LGGYRCGCPQ GYVQHYQWNQ CVDENECSSP
TTCGSASCYN TLGSFKCVCP SGFDFDQAFG GCQDVDECSA GGSPCSYGCS NTDGGYLCGC
PGGYFRAGQG HCISGLGFGK GTYLPAPQEE DEDNLLSPET CYECKINGYP KRGRQRRSIN
GTERHQDHTV NLASMDVDAP LSMTLNLSDL AHKEHILELL PAVEPLENRV RYLISHGNED
GYFRIHQKEG LSYLHLGRKK IVPGTYLLEI VSVPLYRKRE LQKLEAKNHL NYLAGELGQA
LRMKLQLQLY
//
