ID A0A6J3MIF3_9PEZI Unreviewed; 494 AA.
AC A0A6J3MIF3;
DT 07-OCT-2020, integrated into UniProtKB/TrEMBL.
DT 07-OCT-2020, sequence version 1.
DT 28-JAN-2026, entry version 24.
DE RecName: Full=GPI transamidase component PIG-S {ECO:0008006|Google:ProtNLM};
GN ORFNames=K489DRAFT_386179 {ECO:0000313|RefSeq:XP_033464719.1};
OS Dissoconium aciculare CBS 342.82.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Dothideomycetidae; Mycosphaerellales; Dissoconiaceae; Dissoconium.
OX NCBI_TaxID=1314786 {ECO:0000313|RefSeq:XP_033464719.1};
RN [1] {ECO:0000313|RefSeq:XP_033464719.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CBS 342.82 {ECO:0000313|RefSeq:XP_033464719.1};
RG DOE Joint Genome Institute;
RA Haridas S., Albert R., Binder M., Bloem J., Labutti K., Salamov A.,
RA Andreopoulos B., Baker S.E., Barry K., Bills G., Bluhm B.H., Cannon C.,
RA Castanera R., Culley D.E., Daum C., Ezra D., Gonzalez J.B., Henrissat B.,
RA Kuo A., Liang C., Lipzen A., Lutzoni F., Magnuson J., Mondo S., Nolan M.,
RA Ohm R., Pangilinan J., Park H.-J., Ramirez L., Alfaro M., Sun H., Tritt A.,
RA Yoshinaga Y., Zwiers L.-H., Turgeon B.G., Goodwin S.B., Spatafora J.W.,
RA Crous P.W., Grigoriev I.V.;
RL Submitted (JAN-2020) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|RefSeq:XP_033464719.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CBS 342.82 {ECO:0000313|RefSeq:XP_033464719.1};
RG NCBI Genome Project;
RL Submitted (APR-2020) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|RefSeq:XP_033464719.1}
RP IDENTIFICATION.
RC STRAIN=CBS 342.82 {ECO:0000313|RefSeq:XP_033464719.1};
RG RefSeq;
RL Submitted (AUG-2025) to UniProtKB.
CC -!- PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor
CC biosynthesis. {ECO:0000256|ARBA:ARBA00004687}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}.
CC -!- SIMILARITY: Belongs to the PIGS family.
CC {ECO:0000256|ARBA:ARBA00005316}.
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DR RefSeq; XP_033464719.1; XM_033606201.1.
DR AlphaFoldDB; A0A6J3MIF3; -.
DR GeneID; 54364001; -.
DR OrthoDB; 28748at2759; -.
DR UniPathway; UPA00196; -.
DR Proteomes; UP000504637; Unplaced.
DR GO; GO:0042765; C:GPI-anchor transamidase complex; IEA:InterPro.
DR GO; GO:0016255; P:attachment of GPI anchor to protein; IEA:InterPro.
DR GO; GO:0006506; P:GPI anchor biosynthetic process; IEA:UniProtKB-UniPathway.
DR InterPro; IPR019540; PtdIno-glycan_biosynth_class_S.
DR PANTHER; PTHR21072; GPI TRANSAMIDASE COMPONENT PIG-S; 1.
DR PANTHER; PTHR21072:SF13; GPI TRANSAMIDASE COMPONENT PIG-S; 1.
DR Pfam; PF10510; PIG-S; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW GPI-anchor biosynthesis {ECO:0000256|ARBA:ARBA00022502};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000504637};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 31..50
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..12
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 494 AA; 53901 MW; A67A4BCB2FF1487A CRC64;
MASDPKEVER DVAPASGPPA ERPTAIWTRR FVILAFWAVV VCLGLPLWTW TTTIHRSELP
LESMNAWAEG HACKFHFPLQ ISLSASHLSA ELRRDVASRT QDLLNGRGTG SLHTFNVSFD
EARNTTALVV FLTNQQPDEP PKAKLRTWEP VLDAEVNIDT ADAVADTAIF LAQQISDLFD
DEGAFLASLL HSSPFESSSH QLQSFEQQAK LDGRNTRAFK YASTYHLTFS LITPHGSPSA
WEIEQALSES ISKLIKPLSA ISHFVVNTQV QLFARFSPSI AGPTFDSANN RWKLQHEDLS
GFVNAAEWPL SPSIGSGPTI NFILYVPAPD QNPLSIGESG QTSWIIPQWG GVQVHNALNN
TAGRLTAQDL EDDMLVFAEQ LTTLLGVPQT PPSLSLRISS LARERATSLI LSASSTLGAL
ARLTLKLTSI AIPDSVAKSV DATIYRLDQA CRNLNAGQSN GRAVGHGWVE GDPEVTRKKS
EDLVKSKHSL KSIS
//
