ID A0A6J3PWW5_TURTR Unreviewed; 478 AA.
AC A0A6J3PWW5;
DT 07-OCT-2020, integrated into UniProtKB/TrEMBL.
DT 07-OCT-2020, sequence version 1.
DT 28-JAN-2026, entry version 25.
DE RecName: Full=Paired box protein Pax-8 {ECO:0000256|ARBA:ARBA00039822};
GN Name=PAX8 {ECO:0000313|RefSeq:XP_033694579.1};
OS Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Delphinidae; Tursiops.
OX NCBI_TaxID=9739 {ECO:0000313|Proteomes:UP000245320, ECO:0000313|RefSeq:XP_033694579.1};
RN [1] {ECO:0000313|RefSeq:XP_033694579.1}
RP IDENTIFICATION.
RC TISSUE=Spleen {ECO:0000313|RefSeq:XP_033694579.1};
RG RefSeq;
RL Submitted (AUG-2025) to UniProtKB.
CC -!- SUBUNIT: Interacts with WWTR1. {ECO:0000256|ARBA:ARBA00038672}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_033694579.1; XM_033838688.1.
DR AlphaFoldDB; A0A6J3PWW5; -.
DR FunCoup; A0A6J3PWW5; 27.
DR GeneID; 101329017; -.
DR CTD; 7849; -.
DR InParanoid; A0A6J3PWW5; -.
DR OrthoDB; 3225452at2759; -.
DR Proteomes; UP000245320; Chromosome 14.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:TreeGrafter.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:TreeGrafter.
DR CDD; cd00131; PAX; 1.
DR FunFam; 1.10.10.10:FF:000013; Paired box 8 isoform 1; 1.
DR FunFam; 1.10.10.10:FF:000003; Paired box protein Pax-6; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR009057; Homeodomain-like_sf.
DR InterPro; IPR043182; PAIRED_DNA-bd_dom.
DR InterPro; IPR001523; Paired_dom.
DR InterPro; IPR022130; Pax2_C.
DR InterPro; IPR043565; PAX_fam.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR45636; PAIRED BOX PROTEIN PAX-6-RELATED-RELATED; 1.
DR PANTHER; PTHR45636:SF6; PAIRED BOX PROTEIN PAX-8; 1.
DR Pfam; PF00292; PAX; 1.
DR Pfam; PF12403; Pax2_C; 1.
DR PRINTS; PR00027; PAIREDBOX.
DR SMART; SM00351; PAX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00034; PAIRED_1; 1.
DR PROSITE; PS51057; PAIRED_2; 1.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Paired box {ECO:0000256|ARBA:ARBA00022724};
KW Reference proteome {ECO:0000313|Proteomes:UP000245320};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 30..156
FT /note="Paired"
FT /evidence="ECO:0000259|PROSITE:PS51057"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 180..245
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..11
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 180..203
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 478 AA; 50785 MW; 0F95514A8FB1B2D7 CRC64;
MSVLEALERG PADSLPGGPD NRPPDYCVSG HGGLNQLGGA FVNGRPLPEV VRQRIVDLAH
QGVRPCDISR QLRVSHGCVS KILGRYYETG SIRPGVIGGS KPKVATPKVV EKIGDYKRQN
PTMFAWEIRD RLLAEGVCDN DTVPSVSSIN RIIRTKVQQP FNLPMDGCVA TKSLSPGHTL
IPSSAVTPPE SPQSDSLGST YSITGLLGVA QPGSDSKRKL DDSDQDSCRL SLDSQSSGSG
PRKHLRTDAF SQHHLEPLEC PFDRQPYPEA YVSPSHTKGE QGLYPLPLLN SALDDGKATL
TPSNTPLGRN LSTHQTYPVV ADPHSPFAIK QETPEVSSSS STPSSLSSSA FLDLQQVGSG
VPAGASVPPF NAFPHAASVY GQFTGQALLS GREMVGPTLP GYPPHIPTSV QGSYTSSAIA
GMVAGSEYSG NAYGHTPYSS YSEAWRFPNS SLLSSPYYYS STTRPSAPPT TAAAFDHL
//
