ID A0A6J3QJE4_TURTR Unreviewed; 2591 AA.
AC A0A6J3QJE4;
DT 07-OCT-2020, integrated into UniProtKB/TrEMBL.
DT 07-OCT-2020, sequence version 1.
DT 28-JAN-2026, entry version 26.
DE SubName: Full=Multiple epidermal growth factor-like domains protein 8 isoform X3 {ECO:0000313|RefSeq:XP_033702309.1};
GN Name=MEGF8 {ECO:0000313|RefSeq:XP_033702309.1};
OS Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Delphinidae; Tursiops.
OX NCBI_TaxID=9739 {ECO:0000313|Proteomes:UP000245320, ECO:0000313|RefSeq:XP_033702309.1};
RN [1] {ECO:0000313|RefSeq:XP_033702309.1}
RP IDENTIFICATION.
RC TISSUE=Spleen {ECO:0000313|RefSeq:XP_033702309.1};
RG RefSeq;
RL Submitted (AUG-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_033702309.1; XM_033846418.1.
DR GeneID; 101320059; -.
DR CTD; 1954; -.
DR Proteomes; UP000245320; Chromosome 19.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProtKB-ARBA.
DR GO; GO:0048731; P:system development; IEA:UniProtKB-ARBA.
DR CDD; cd00041; CUB; 1.
DR CDD; cd00054; EGF_CA; 2.
DR FunFam; 2.10.25.10:FF:000202; Multiple epidermal growth factor-like domains 8; 1.
DR FunFam; 2.10.25.10:FF:000214; Multiple epidermal growth factor-like domains 8; 1.
DR FunFam; 2.10.25.10:FF:000331; Multiple epidermal growth factor-like domains 8; 1.
DR FunFam; 2.10.25.10:FF:000532; Multiple epidermal growth factor-like domains 8; 1.
DR FunFam; 2.120.10.80:FF:000030; Multiple epidermal growth factor-like domains 8; 1.
DR FunFam; 2.120.10.80:FF:000033; Multiple epidermal growth factor-like domains 8; 1.
DR FunFam; 2.120.10.80:FF:000052; Multiple epidermal growth factor-like domains 8; 1.
DR FunFam; 2.60.120.290:FF:000023; Multiple epidermal growth factor-like domains 8; 1.
DR FunFam; 2.120.10.80:FF:000051; Multiple epidermal growth factor-like domains protein 8; 1.
DR Gene3D; 2.120.10.80; Kelch-type beta propeller; 4.
DR Gene3D; 2.10.25.10; Laminin; 5.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR InterPro; IPR056737; Beta-prop_ATRN-MKLN-like.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR000742; EGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR002049; LE_dom.
DR InterPro; IPR056863; LMN_ATRN_NET-like_EGF.
DR InterPro; IPR024731; NELL2-like_EGF.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR PANTHER; PTHR46093; ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5; 1.
DR PANTHER; PTHR46093:SF16; MULTIPLE EGF-LIKE-DOMAINS 8; 1.
DR Pfam; PF24981; Beta-prop_ATRN-LZTR1; 2.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF24973; EGF_LMN_ATRN; 1.
DR Pfam; PF23106; EGF_Teneurin; 1.
DR Pfam; PF01437; PSI; 1.
DR SMART; SM00042; CUB; 1.
DR SMART; SM00181; EGF; 11.
DR SMART; SM00179; EGF_CA; 2.
DR SMART; SM00423; PSI; 9.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF117281; Kelch motif; 2.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS01180; CUB; 1.
DR PROSITE; PS00022; EGF_1; 3.
DR PROSITE; PS01186; EGF_2; 4.
DR PROSITE; PS50026; EGF_3; 4.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS01248; EGF_LAM_1; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Kelch repeat {ECO:0000256|ARBA:ARBA00022441};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000245320};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..2591
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5027031618"
FT TRANSMEM 2394..2416
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 30..140
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 170..203
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1074..1115
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1205..1247
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1924..1962
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 2268..2310
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2566..2591
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2273..2286
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2288..2304
FT /note="Gly residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2566..2577
FT /note="Gly residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2582..2591
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 30..57
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00059"
FT DISULFID 174..184
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 193..202
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1237..1246
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2591 AA; 276319 MW; 4C6BB4DFAE24F9CB CRC64;
MALGRALAAA LALSFSVLWP LSPGARAGDC KGQRQVLREA PGFVTDGAGN YSVNGNCEWL
IEAPSSQYRI LLDFLFLDTE CTYDYLFVYD GDSPRGPLLA SLSGSTRPPP IEASSGKMLL
HLFSDANYNL LGFNASFRFS LCPGGCYSHG QCQPPGVCVC EPGWGGPDCG LQECPAYCGS
HGTCASPLGP CLCEPGFLGR ACDLHLWENQ GAGWWHNVSA GDPAFSARIG AAGAFLSPPG
LLAVFGGQDL NRALGDLVLY NFSANTWERW DLSPAPAARH SHVAVAWAGS LVLMGGELAD
GSLTSDVWAF SPLGGGHWEL LAPAASSSSG PPGLAGHAAA LVDSIWLYVS GGRTQHDLFS
SGLFRFRLDS TSGGYWEQVI PAGGRPPAAT GHSMVFHAPS RALLVHGGHR PSTARFSVRV
NSTELFHVDR RVWTSLKGRD GLQGPRERAF HTASVLGNYM VVYGGNVHTH YQEEKCYEDG
IFFYHLGCHQ WVSGAELAPP GTPEGRAAPP SGRYSHVAAV LGGSVLLVAG GYSGRPRGDL
MAYKVPPFVF QAPAPDYHLD YCSMYTDHSV CSRDPECSWC QGACQAAPPP GTPSGACPAA
SCLGLGRLLG DCQACLAFSS TAAPPRGPGA LGWCVHNESC LPRPEQARCR GEQISGTVGW
WGPVPVFVTS LEACVTQSFL PGLHLLTFQQ PPNASQPDKV LIVRSTTITL TPSSETDVSV
VYRGFIHPLL PGGPGGPGAE DVAVWARAQR LHVLARMARG PDAENMEEVG RWVAQQEKET
RRLQRPGSAR LFPLPGRGHK YAVEIRGQLN GSAGPGHSEL TLLWDRTGVP GGSEISFFFL
EPYRSSACAS YPSCLGCLAD QGCGWCLASA TCHLRQSGAH CGDRGAGGSL LVLVPALCPL
CEEHRDCHAC TQDPFCEWHQ STSRKGDAAC SRRGRGRGAL KSLQECPPLC SQRLTCDDCL
ANSSQCAWCQ STHTCFMFAA YLARYPHGGC RGWDDSVHSE PRCRSCDRFL TCHECLQSHE
CGWCGNEDNP TLGRCLQGDF SGPLGGGNCS LWVGEGLGLS VALPARWAYA RCPDVDECRL
GLARCHLRAT CLNTPLSYEC HCQRGYQGDG ITYCNRTCLE DCGHGVCSGP PDFTCVCDLG
WTSDLPPPTP APGPPAPRCS RDCGCNFHSH CHKRGPGFCD ECQGLLVLHW EANGSSSWGF
NASVGSARCG SGGPGSCPVP QECVPQDGAA DAGLCRCPQG WAGPHCRMAL CPENCNAHNG
AGTCNQSLGV CICAEGFGGP DCATKLDGGQ LVWETLMDSR LSADTASRFL HRLGHTMVEG
PEATLWMFGG LGLPQGLLGN LYRYSVSERR WTQMLAGAED GGPGPSPRSF HAAAYVPAGR
GAMYLLGGLT AGGVARDFWV LNLTTLQWRQ EKAPQTVELP AVAGHTLTAR RGLSLLLVGG
YSPENGFNQQ LLEYQLATGT WVSGAQSGTP PTGLYGHSAV YHEATDSLYV FGGFRFHVEL
AAPSPELYSL HCPDRTWSLL APSQGAKPRP RLFHASALLG DTMVVLGGRS DPDEFSSDVL
LYQVNCNTWL LPDLIRPASV GPPMEESVAH AVAAVGGRLY ISGGFGGVAL GRLLALTLPP
DPCHLLPSPE ACNQSGACTW CHGACLSGDQ AHRLGCGGPP CSPMPHSPEE CRRLRTCSEC
LARHPRTLQP GDGEASAPRC KWCTNCPEGA CIGRNGSCTS ENDCRINQRE VFWAGNCSEA
VCGAADCKQC TREGKCMWTR QFKRTGETRR ILSVQPTYDW TCFSHSLLNV SPMPVESSPP
LPCPTPCHLL PNCTSCLDSK GADGGWQHCV WSSSLQQCLS PSYLPLRCMA GGCGRLLRGP
ESCSLGCAQA TQCALCLRRP HCGWCAWGGQ DGGGRCLEGG LSGPRDGLTC GRPGASWAFL
SCPPEDECAN GHHDCNETQN CHDRPHGYEC SCKTGYTMDN VTGLCRPVCA QGCVNGSCVE
PDHCRCHFGF VGHNCSTECR CNRHSECAGV GARDHCLLCH NHTKGSHCEQ CLPLFVGSAV
GGGTCRPCHA FCRGNSQVCV SRKELEMARR EPEKYSLDPE EIENWVTEGP SEDEAVCVNC
HNNSYGDKCE SCLHGYFLLD GKCTKCQCNG HADTCNEQDG TGCPCQNNTE TGTCQGSSPS
DRRDCYKYQC AKCRESFHGS PLGGQQCYRL ISVEQEYCLD PTSQTNCFHE PKRRALGPGR
TVLFGVQPKF TNVDIRLTLD VTFGAVDLYV STSYDTFVVR VAPDTGVHTV HIQPPPPPPA
PPPPADGGPR GAGDLGGPGA GGGPATPAEP RVREVWPRGL ITYVTVTEPS VVLVVRGVRD
RLVITYPHEH HTLKSSRFYL LLLGVGDPSG PSANGSADSQ GLLFFRQDQA HIDLFVFFSV
FFSCFFLFLS LCVLLWKAKQ ALDQRQEQRR HLQEMTKMAS RPFAKVTVCF PPDPAAPAPA
WKPAGLPPPT FRRSEPFLAP LLLTGAGGPW GPVGGSCCPP TIPATTAGLR AGPITLEPTE
DGMAGVATLL LQLPGGPHAP NGACLGSALV TLRHRLHEYC GGSGGAGGGG HGAGAGRKGL
LSQDNLTSMS L
//
