ID A0A6J8E123_MYTCO Unreviewed; 1921 AA.
AC A0A6J8E123;
DT 07-OCT-2020, integrated into UniProtKB/TrEMBL.
DT 07-OCT-2020, sequence version 1.
DT 28-JAN-2026, entry version 21.
DE SubName: Full=ABCA1 {ECO:0000313|EMBL:CAC5414479.1};
GN ORFNames=MCOR_47272 {ECO:0000313|EMBL:CAC5414479.1};
OS Mytilus coruscus (Sea mussel).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Mytilida; Mytiloidea; Mytilidae; Mytilinae;
OC Mytilus.
OX NCBI_TaxID=42192 {ECO:0000313|EMBL:CAC5414479.1, ECO:0000313|Proteomes:UP000507470};
RN [1] {ECO:0000313|EMBL:CAC5414479.1, ECO:0000313|Proteomes:UP000507470}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=wild {ECO:0000313|Proteomes:UP000507470};
RA Li R., Bekaert M.;
RL Submitted (JUN-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCA family.
CC {ECO:0000256|ARBA:ARBA00008869}.
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DR EMBL; CACVKT020008349; CAC5414479.1; -; Genomic_DNA.
DR OrthoDB; 10255969at2759; -.
DR Proteomes; UP000507470; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0005319; F:lipid transporter activity; IEA:TreeGrafter.
DR CDD; cd03263; ABC_subfamily_A; 1.
DR FunFam; 3.40.50.300:FF:000264; ATP-binding cassette, sub-family A (ABC1), member 1; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 5.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC2_TM.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR026082; ABCA.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR PANTHER; PTHR19229:SF36; ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 2; 1.
DR PANTHER; PTHR19229; ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA; 1.
DR Pfam; PF12698; ABC2_membrane_3; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR Pfam; PF07699; Ephrin_rec_like; 3.
DR SMART; SM00382; AAA; 1.
DR SMART; SM01411; Ephrin_rec_like; 7.
DR SUPFAM; SSF57184; Growth factor receptor domain; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000507470};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 23..42
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1086..1107
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1128..1150
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1162..1182
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1189..1207
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1271..1292
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1352..1583
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT REGION 1586..1660
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1605..1614
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1921 AA; 214926 MW; 659D70EFA77708E9 CRC64;
MGFGTQLKIL LWKNFTIRKR QKFRLFAEIV FPLALFLILV IVRTRPDLKV NHAECHFDGN
AMPSAGTWPF LQSLVCNAEN RCYQTVTADE AAGTTASGNP QDLITRILKD IGELADPKLI
QNLLKDGQII MRVLGMIRNG TATGGINLGN IVTNPTDLRN QIINNNISLS PNVIDQLLNA
TINPALPTGV LFDFGECQLI QNNRTSGGIP NTTVQDLRSL LCDRNLNETI IFPTQSLQDT
VQTQLCNLSL VQFDELYGLL LSALNNTRSN EEILDYIERN AGEELLSNPA ELLQFYNDFT
TLYQEYQNDR DVIETVESLF NQLQGTTMGQ SVNGTAMVQS LVCGRGSTKC RPGYYIAGSS
CFPCKIGTYQ PNANQGSCIQ CEDYLKTNST ASTKEDDCQV NCGAGQEGDD DCSNCKSGYY
KPSAGIYPCM KCPLHTTSNQ VRTECNILNC SPGYHINNGL CIQCLKGYYQ TEYNKTSCTA
CPSNHDTQNT GSSKSTDCQK ICPAGTEGDS CKKCEKGYYK STSGIQGCMK CPDGYTASDD
KTKCILGCKA GSYIDGNKCS PCGYGTYQPD LAQTSCLSCD FNKNTTFTGS DKKDDCKVYC
GPGEEGTDTC SPCKDDYYKS TGGRTACLQC TGHMTSTKND RTKCTVLFCD RGYFYNAVDN
TCKLCPEGEY KSERGMEKMC QACTARYEVI GNPGTQCKRT VCADLVDNLK SNSFGNAIWK
QLKPLVEGKI PYAPNTTAIN DVIKLANKTF EDLFNIVDLA RSWRAESDVL FNFLETNPEI
QLLRDFTCSE VCDNLWHTLR RTACNGTLPG FNISSLLSGL NFGGFDIASL IPGLATGGMN
DFLSQIPGFN QSGLTALCDV DPNYSPCESL FQFLYSGSDI NISNYTWKDA LENVNSVLEM
VSEYGKCFVF DKFEGFKSEY ELTARALQLI GQNKYFGAIV FDKEHKNGLE SHVKYSIRMN
QDRVDSTNRI QSRYWRPGPR STPGIDTKYV TYGFAYLQDM IDHAIIKIQT YNTSDIGVIT
QMYWRPGPRT YYRYLRYGFV FLQDMIDHAI VKIQTNNTSD IGVILQQFPY PCYIQDKFIY
AISRTLPLFL VLAWVLSVAM ICKNIVYEKE MRLKEVMKIM GLGNGVHWLA WFIDAFIVMF
ISLILMVIIL KAGKVLEHSD PTVILFMLTA FTVATISQCF LFSVFFSKAN IAACVAGFLY
FMLYLIYPLC TQWEELMTST HKSLAGLSSS VAFGFACSYV ARYEEQAIGV QWSNIGQTPI
VDDDYSCLNC IVMMIVDAII YGLFTWYIEA VFPGQYGIPR KFYFPFLKSY WCGSSISKDR
SDQYMYQGST MELKGQGNAN VEEEPKNKKV GVSIRNLKKV YKNGNKVAVD GLSINFYEGQ
ISSFLGHNGA GKTTTMSILT GLFPPSDGTA FIYGHNILTE MDAVRDSLGM CPQHNVLFDK
LTVEEHLWFY ARLKNLEPEK VKREMVRMIQ DVGLPHKKKE LSSSLSGGMK RKLSVAIAFV
GNAKTVILDE PTAGIDPYAR KEIWEILLKL KKKRTIILST HHMDEADVLG DRIAIISQGK
LCCCGSSLYL KSQYGNGYYL TLVQDDGKGN DKEDSDDEMD FMESRPQSRG SVRTTVDVKP
IVNKQSDIED EGFGDNSDDK SESGGSKPPT PPPESATMVP GFSTKRTTEF IGKYVKKAKL
VEESSTELTY QLPSEAAYSG QFEQLFKQLE RCHKDMGISS FGISDTSLEE VFLRVADETG
VDQDDEAKRK KLEEGTDSGR FAKPVTRLSF RRKKKKSFLK MLAIKGKNPK VDSEELMDDN
ESVISVPTSE KNIETGFSHK DHVKHTGIRL KLQQFKAIFF KRFHRLRRSK KGFFFEIIMP
ALFILASMAL AKIRPPSFGE PPLELQPWMY TPKKGAPNLY TFFRLGLDYY ISTHFVGGLL
Q
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