ID A0A6L3VA36_9BACI Unreviewed; 630 AA.
AC A0A6L3VA36;
DT 07-OCT-2020, integrated into UniProtKB/TrEMBL.
DT 07-OCT-2020, sequence version 1.
DT 28-JAN-2026, entry version 22.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN Name=selB {ECO:0000313|EMBL:KAB2337685.1};
GN ORFNames=F7731_08820 {ECO:0000313|EMBL:KAB2337685.1};
OS Cytobacillus depressus.
OC Bacteria; Bacillati; Bacillota; Bacilli; Bacillales; Bacillaceae;
OC Cytobacillus.
OX NCBI_TaxID=1602942 {ECO:0000313|EMBL:KAB2337685.1, ECO:0000313|Proteomes:UP000481030};
RN [1] {ECO:0000313|EMBL:KAB2337685.1, ECO:0000313|Proteomes:UP000481030}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BZ1 {ECO:0000313|EMBL:KAB2337685.1,
RC ECO:0000313|Proteomes:UP000481030};
RX PubMed=26452774; DOI=10.1007/s10482-015-0605-1;
RA Wei X., Xin D., Xin Y., Zhang H., Wang T., Zhang J.;
RT "Bacillus depressus sp. nov., isolated from soil of a sunflower field.";
RL Antonie Van Leeuwenhoek 109:13-20(2016).
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAB2337685.1}.
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DR EMBL; WBOS01000002; KAB2337685.1; -; Genomic_DNA.
DR RefSeq; WP_151534388.1; NZ_WBOS01000002.1.
DR AlphaFoldDB; A0A6L3VA36; -.
DR OrthoDB; 9804504at2; -.
DR Proteomes; UP000481030; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR CDD; cd04171; SelB; 1.
DR CDD; cd03696; SelB_II; 1.
DR CDD; cd15491; selB_III; 1.
DR Gene3D; 1.10.10.2770; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR050055; EF-Tu_GTPase.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR015190; Elong_fac_SelB-wing-hlx_typ-2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR005225; Small_GTP-bd.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00475; selB; 1.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43721:SF22; ELONGATION FACTOR TU, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF09106; WHD_2nd_SelB; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Elongation factor {ECO:0000313|EMBL:KAB2337685.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000481030}.
FT DOMAIN 3..176
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 630 AA; 72187 MW; 6E48862CA7BAD130 CRC64;
MSKRYFTIGM AGHIDHGKTT LTKALTNVDT DRLKEEKERQ ISIELGFAPL YEDQELQISV
VDVPGHERFI RQMIAGVAGI DLVVLVVAAD EGVMPQTHEH LQILELLGVK NGIIAITKIN
RVEEEFIDLV KDDILEELKG TVFENAPFML VDSITKQGIC DLKNMIINDL KKLGQRDIRG
AFRLPIDQVF TVRGQGTVVR GTVFEGTVEE GQALMIMPKG LETRARQLQV HHKPAKHAFA
GQRTAINLAG ITKEELQRGD VLVSSEQFIV SDTIDVALQV VSDLDYIVKQ RMPIKCHIGT
AEVMGRIVFF DRNEVKDEER EILCQIRLEE EIVTKRGDRF IIRRPSPQET IGGGWVIEPK
GEKYRFGNNT VEELERKKEG TPTERILAVL KEAKSLSKQE LLKRASITGA ELETCEHNNE
IYFYGGKEFT LFSIYETINQ EIDERLQDFH NKYPLKQGMN KAELIQLISK GYPRKLAEFV
LEQGIDESDF GKIDQFIFGK GFSPYIPKNW QKRVENMLID MSRDGYKVKY LNDYLSKAGI
PNDMVTDLKR FLEETHEIIS LDAQFYWCID HFTAAVERVK SETSLEFEIG EAKDILNLSR
KYMIPFLERL DELGYTKRVE NKRLWQPIVK
//
