ID A0A6N4WHZ4_9MYCO Unreviewed; 307 AA.
AC A0A6N4WHZ4;
DT 07-OCT-2020, integrated into UniProtKB/TrEMBL.
DT 07-OCT-2020, sequence version 1.
DT 08-OCT-2025, entry version 21.
DE SubName: Full=Cyclopropane-fatty-acyl-phospholipid synthase {ECO:0000313|EMBL:BBZ79532.1};
GN ORFNames=MANY_48690 {ECO:0000313|EMBL:BBZ79532.1};
OS Mycolicibacterium anyangense.
OC Bacteria; Bacillati; Actinomycetota; Actinomycetes; Mycobacteriales;
OC Mycobacteriaceae; Mycolicibacterium.
OX NCBI_TaxID=1431246 {ECO:0000313|EMBL:BBZ79532.1, ECO:0000313|Proteomes:UP000467249};
RN [1] {ECO:0000313|EMBL:BBZ79532.1, ECO:0000313|Proteomes:UP000467249}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 30275 {ECO:0000313|EMBL:BBZ79532.1,
RC ECO:0000313|Proteomes:UP000467249};
RX PubMed=31287781; DOI=10.1080/22221751.2019.1637702;
RA Matsumoto Y., Kinjo T., Motooka D., Nabeya D., Jung N., Uechi K., Horii T.,
RA Iida T., Fujita J., Nakamura S.;
RT "Comprehensive subspecies identification of 175 nontuberculous mycobacteria
RT species based on 7547 genomic profiles.";
RL Emerg. Microbes Infect. 8:1043-1053(2019).
CC -!- SIMILARITY: Belongs to the CFA/CMAS family.
CC {ECO:0000256|ARBA:ARBA00010815}.
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DR EMBL; AP022620; BBZ79532.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A6N4WHZ4; -.
DR KEGG; many:MANY_48690; -.
DR Proteomes; UP000467249; Chromosome.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR FunFam; 3.40.50.150:FF:000115; Cyclopropane mycolic acid synthase 1; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR050723; CFA/CMAS.
DR InterPro; IPR003333; CMAS.
DR InterPro; IPR047672; CMAS_actinobact.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; NF040660; mycolic_MTase; 1.
DR PANTHER; PTHR43667; CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE; 1.
DR PANTHER; PTHR43667:SF1; CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE; 1.
DR Pfam; PF02353; CMAS; 1.
DR PIRSF; PIRSF003085; CMAS; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 3: Inferred from homology;
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000467249};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 286
FT /evidence="ECO:0000256|PIRSR:PIRSR003085-1"
FT BINDING 49..50
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PIRSR:PIRSR003085-2"
FT BINDING 84..92
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PIRSR:PIRSR003085-2"
FT BINDING 110..115
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PIRSR:PIRSR003085-2"
FT BINDING 140..141
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PIRSR:PIRSR003085-2"
SQ SEQUENCE 307 AA; 35406 MW; 888BCFF34AF59B57 CRC64;
MSQSIPHAQS QWLSKSASQT RGSDKDEVQF HYDISNEFFK LWQDPTQTYS CAYFEHDEMT
LEEAQLAKVD LALGKLGLQP GMTLLDIGCG WGSTIMRAVE KYDVNVIGLT LSENQRRHIE
EHWFANSKSL RHKEVRLQPW EEFDGKVDRI VSIGAFEHFG FNKYDDYFKK TFSWLPDDGV
MLLHTIIIPE DEEIKAKGLP LTMSRVRFIK FIMDEIYPGG RLPLASMVRK HAVTAGYAVT
REQHLQPHYA RTLDTWASNL EDTKDEAIAI TSAEIYERFH RYLTGCADLF RNGYTDVCQF
TCEKAVN
//
